N,N-ジエチルニコチンアミド

N,N-Diethylnicotinamide

HCID 5497

基本情報

CAS
59-26-7
標準SMILES
CCN(CC)C(=O)c1cccnc1
InChIKey
NCYVXEGFNDZQCU-UHFFFAOYSA-N
分子式
C10H14N2O
平均分子量
178.23 g/mol
単同位体質量
178.11061307

概要

Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992)

名称と識別子

優先名称
N,N-Diethylnicotinamide
IUPAC
N,N-diethylpyridine-3-carboxamide
現地名
N,N-ジエチルニコチンアミド
英語名
N,N-Diethylnicotinamide
分子式
C10H14N2O
分子量
178.23

名称と別名

NikethamideN,N-DIETHYLNICOTINAMIDE59-26-7NicethamideNikethylNiquetamidaN,N-diethylpyridine-3-carboxamideNicethamidumCarditonicDiaethylamidum acidi nicotiniciDTXSID9046524NSC-130820
名称をさらに表示
N,N-ジエチルニコチンアミドコラコンニコリンアストロカルコルビトールイニカルジオニケチルコルメドコルミドニカミドカルジアミドユーコランサバカルドスチムリンアナカルドンニカルジンN,N-ジエチル-3-ピリジンカルボアミドコラミン(薬物)ディナコリルニコルNikotinNiketamideCORVOTONETonocardnicorNi-CorCorivoCormedCormid
368IVD6M32DTXCID7026524CorethamidNizethamidDiethylnicotinamidNicotinic DiethylamideNIKETHAMIDUMDiethylamide, Nicotinic

データベース識別子

CAS
59-26-7
PubChem CID
5497
DTXSID
DTXSID9046524
ChEMBL
CHEMBL2104607
ChEBI
CHEBI:134814
UNII
368IVD6M32
EC Number
200-418-5
Nikkaji
J5.179I

物性

構造計算による物性

XLogP
0.3
極性表面積
33.2 Ų
水素結合供与体数
0
水素結合受容体数
2
回転可能結合数
3
重原子数
13

実験および物理化学的性質

Drugs · 2 件

DEA NFLIS-Drug Category -> Stimulants

Pharmaceuticals -> Used in Switzerland

SpringerMaterials PropertiesChemical shift
Density1.058 to 1.066 at 77 °F (NTP, 1992)
Solubilitygreater than or equal to 100 mg/mL at 73 °F (NTP, 1992)
Flash Point235 °F (NTP, 1992)
Human DrugsPharmaceuticals

物理化学的性質

融点
23 °C · 23 °C (lit.)
沸点
296 · 296-300 °C (lit.)
比重(密度)
1.06 g/mL · 1.06 g/mL at 25 °C (lit.)
屈折率
20 · n20/D 1.524(lit.)
闪点
230 °F · >230 °F
貯蔵温度
2 · 2-8°C

化学的性質

化学的特性clear colorless to yellow liquid

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 85 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Status: Active Update: 02-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/19676

3-Pyridinecarboxamide, N,N-diethyl-: Does not have an individual approval but may be used under an appropriate group standard

DOT LabelPoison
Fire HazardsThis chemical is combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
Reactive GroupAmides and Imides
Reactivity ProfileNICETHAMID is incompatible with sodium carbonate solutions which cause precipitation. (NTP, 1992).

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全データ

wgk
3
rtecs
QS4375000
ridadr
UN 2811 6.1/PG 3
毒性
LD50 i.p. in rats: 272 mg/kg (Goldenthal)
hs_code
29333999
risk_code
25-36/37/38-23/24/25

化学と産業

薬理情報

ATC Code · 2 件

R - Respiratory system

QR - Respiratory system

MeSH Pharmacological Classification · 2 件

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.

用途と製造

Use ClassificationPharmaceuticals
応用分野 · 3 件

説明A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

使用analeptic

一般的な説明Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

サプライヤー100 社

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
Shanghai Biolang Biotechnology Co., Ltd.+86-15970428662 +86-13397199602 · [email protected]
江苏瑞点药业有限公司15896106238 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]

関連反応

2 件

化合物ノート

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