2-((S)-3-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid hydrochloride

Benazepril USP RC B · (1R,3S)-Benazepril HCl · Benner Pury hydrochloride · Benazepril Hydrochloridec · Benazepril Related CoMpound B · (1R,3S)-Benazepril Hydrochloride · Benazepril USP Related Compound B · (1R,3S)-Benazepril Hydrochloride USP/EP/BP

https://huagongshe.com/ja/chemical/55513

2-((S)-3-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid hydrochloride の分子構造式

識別子と物理属性

CAS No.	86541-77-7
分子式	C24H29ClN2O5
平均分子量	460.9 g/mol
単同位体質量	460.1764997 g/mol
SMILES	CCOC(=O)[C@@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O.Cl
InChIKey	VPSRQEHTHIMDQM-CMXBXVFLSA-N
PubChem CID	55513

化学・物理的性質

極性表面積	95.9
水素結合供与体数	3
水素結合受容体数	6
回転可能結合数	10
重原子数	32
形式電荷	0
複雑度	619
融点	181-183 °C(Solv: 2-butanone (78-93-3))
貯蔵条件	2-8°C
外観・状態	powder
主な用途	医薬品低分子化合物
InChIKey	VPSRQEHTHIMDQM-CMXBXVFLSA-N
SMILES	Cl.N1(c2c(cccc2)CC[C@@H](C1=O)N[C@H](CCc3ccccc3)C(=O)OCC)CC(=O)O

安全性と法規制

税関コード	2933790002
貯蔵分類	11 - Combustible Solids

用途

使用

(1R,3S)-Benazepril Hydrochloride is an isomer of Benazepril (B119750), an angiotensin converting enzyme inhibitor and a antihypertensive agent.

一般的な説明

Benazepril hydrochloride,(3S)-3-[[(1S)-1-carbethoxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 3-ethylester hydrochloride (Lotensin), is metabolized rapidly to theactive diacid benazaprilat. As with the ACE prodrugs, nomutagenicity has been found, even though these drugs crossthe placenta.