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HCID 5564作成日：2026年10月27日

トリクロサン

2,4,4'-トリクロロ-2'-ヒドロキシジフェニルエーテル · (4-クロロ-2-ヒドロキシフェニル)(2,4-ジクロロフェニル)エーテル · 2,4-ジクロロフェニル(2-ヒドロキシ-4-クロロフェニル)エーテル · イルガサン · 2-(2,4-ジクロロフェノキシ)-5-クロロフェノール · 2,4-ジクロロフェニル(4-クロロ-2-ヒドロキシフェニル)エーテル · トリクロサン · イルガサンDP-300

https://huagongshe.com/ja/chemical/5564

トリクロサン の分子構造式

識別子と物理属性

CAS No.3380-34-5
分子式C12H7Cl3O2
平均分子量289.5 g/mol
単同位体質量287.9511625 g/mol
SMILESOc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
InChIKeyXEFQLINVKFYRCS-UHFFFAOYSA-N
PubChem CID5564
ChEMBLCHEMBL849
ChEBICHEBI:164200
EC No.222-182-2
DTXSIDDTXSID5032498
現地名トリクロサン

化学・物理的性質

XLogP5
極性表面積29.5
水素結合供与体数1
水素結合受容体数2
回転可能結合数2
重原子数17
形式電荷0
複雑度252
物質分類Other Uses -> Biocides/Disinfectants
医薬品Pharmaceuticals -> Listed in ZINC15
化粧品Cosmetic ingredients (Triclosan) -> CIR (Cosmetic Ingredient Review)Preservative
SpringerMaterials Properties13C nuclear magnetic resonance spectrum
農薬BiocidePesticide and(or) Waste-water effluent contaminant
LogP（分配係数）log Kow = 4.764.53
臭いSlight, faintly aromatic odor
Color/FormWhite to off-white crystalline powder
溶解度In water, 10 mg/L at 20 °CSlightly soluble in waterReadily soluble in alkaline solutions and many organic solventssoluble in methanol, alcohol, acetoneReadily soluble in organic solventsH2O: 20℃で可溶12g/Lエタノール、メタノール、エーテル、水酸化ナトリウム溶液 (1M) に可溶。水にわずかに溶ける。
Human DrugsFDA approved drugs -> Active ingredient
Endocrine DisruptorsPotential endocrine disrupting compound
沸点280 to 290 °C (decomposes)290°C(lit.)
融点56-60 °C(lit.)
密度1.4214 (rough estimate)
蒸気圧0.001Pa at 25℃
屈折率1.4521 (estimate)
貯蔵条件2-8°C
外観・状態個体
pKa（酸解離定数）7.9(at 25℃)
色無色または白色
由来生物synthetic
Merck14,9657
BRN2057142
ヘンリー定数4.7×102 mol/(m3Pa) at 25℃, HSDB (2015)
安定性安定。強力な酸化剤とは相容れない。
化粧品成分の機能抗菌剤防腐剤デオドラント
InChI1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
InChIKeyXEFQLINVKFYRCS-UHFFFAOYSA-N
SMILESOc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl
LogP（分配係数）4.9 at 20℃
CAS データベース3380-34-5(CAS DataBase Reference)
NISTの化学物質情報Triclosan(3380-34-5)
EPAの化学物質情報Triclosan (3380-34-5)

化学的特性

Solid

安全性と法規制

GHS 分類WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)H315 (99.8%): Causes skin irritation [Warning Skin corrosion/irritation]
規制情報Chemical: Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-Hazard Traits - DermatotoxicityEndocrine ToxicityImmunotoxicityCouncil Directive (EEC) No 109/1989 (Repealed by Reg. EC No 1935/2004 (amended))Triclosan is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Status: Cease Manufacture Update: 21-09-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12675Triclosan: Does not have an individual approval but may be used under an appropriate group standard
その他の安全情報PEC / SN / Other assessments - Triclosan: Health and Environment
有害性の概要Frequently used in antibacterial soaps and infrequently reported as a contact allergen and even less often as a photosensitizer[Marks, p. 235] TLV Basis is hematology effect[ACGIH]
FDA 要件Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: triclosan is included in consumer antiseptic hand wash products.Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: triclosan is included in consumer antiseptic body wash products.The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed over-the-counter drug products, including triclosan, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

用途

用途

石鹸、洗剤、皮膚用シャンプーなどの消毒剤

説明

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis. It is effective against Gram-negative and Gram-positive bacteria, as well as against Mycobacteria. Triclosan is used in a variety of products, including antiseptic soaps, deodorants, and hand washes.

使用

triclosan is a preservative considered to have a low sensitizing potential in leave-on preparations.

一般的な説明

Chemical structure: diphenyl ether derivative

Special ReportsUSEPA/Office of Pesticide ProgramsReregistration Eligibility Decision Document - Triclosan, EPA 739-RO-8009 (September 2008). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of November 6, 2017: http://www.epa.gov/pesticides/reregistration/status.htm]
FIFRA 要件The Agency completed its assessment of the residential, occupational, indirect dietary and ecological risks associated with the use of pesticide products containing the active ingredient triclosan. The Agency has determined that most triclosan containing products are eligible for reregistration provided that: 1) all risk mitigation measures are implemented2) current data gaps and confirmatory data requirements are addressedand 3) label amendments are made as described in Section V. Use as a materials preservative in paint (inclusive of stains and coatings) has been requested to be voluntarily canceled by the registrants and is not eligible for reregistration. Appendix A summarizes the uses of triclosan that are eligible for reregistration. Appendix B identifies the generic data requirements that the Agency reviewed as part of its determination of reregistration eligibility of triclosan and lists the submitted studies that the Agency found acceptable. Data gaps are identified as generic data requirements that have not been satisfied with acceptable data. The Agency considered the available information and has determined that the uses of triclosan that appear in Appendix A of this document will not pose unreasonable risks to humans or the environment if the conditions and requirements for reregistration outlined in this document are implemented. Unless labeled and used as specified in this document, triclosan would present risks inconsistent with FIFRA. Accordingly, should a registrant fail to implement any of the conditions and requirements for reregistration identified in this document, the Agency may take regulatory action to address the potential risk concerns from the use of triclosan.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. 5-Chloro-2-(2,4-dichlorophenoxy)phenol is found on List B. Case No: 2340Pesticide type: insecticide, fungicide, antimicrobialCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.Active ingredient (AI): 5-Chloro-2-(2,4-dichlorophenoxy)phenolData Call-in (DCI) Date(s): 06/07/1991, 03/03/1995, 10/13/1995AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
Hazard Classes and CategoriesSkin Irrit. 2 (99.8%)Acute toxicity - category 3Hazardous to the aquatic environment (Acute) - Category 1
Skin, Eye, and Respiratory IrritationsPure triclosan is irritating to skin and eyes, whereas the low concentrations used in personal hygiene products do not pose an irritant hazard.
Hazardous Reactivities and IncompatibilitiesIncompatible materials: Strong oxidizing agents.
消火手順Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.
保管条件Keep container tightly closed in a dry and well-ventilated place.
清掃方法ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
処分方法SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this materialContaminated packaging: Dispose of as unused product.
Preventive MeasuresACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
Threshold Limit Values (TLV)1.0 [mg/m3]
Personal Protective Equipment (PPE)Eye/face protection: Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protection: Handle with gloves.Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.Respiratory protection: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Other Standards Regulations and GuidelinesThe Canadian government is urging industry to voluntarily remove the antibacterial chemical triclosan from consumer products because of concerns about its toxicity to aquatic organisms. Although triclosan can still be sold and used in Canada in products such as antibacterial soaps, toothpastes, and deodorants, the government plans to work with companies over the next 18 months to better understand usage patterns and to assess alternatives.
体内負荷Triclosan has been detected, not quantified, in human blood plasma from randomly selected male blood donors in Sweden(1). Triclosan was detected in plasma of nursing mothers approximately 6 weeks after delivery at 0.4-38 and 0.018-4.1 ng/g in exposed and controls, respectively, 12 weeks after delivery respective concentrations were 0.49-38 and 0.010-19 ng/g(2). Triclosan was detected in milk of nursing mothers approximately 6 weeks after delivery at 0.32-0.95 and <0.018-0.35 ng/g in exposed and controls, respectively, 12 weeks after delivery respective concentrations were 0.022-0.84 and <0.018-0.33 ng/g(2). This study was run from Oct 2003 to May 2004 in nursing Swedish women (9 exposed, 26 controls)(2). Triclosan was detected in three of five randomly selected Swedish human milk samples at concentrations of 60-300 ug/kg lipid weight(3). Triclosan was detected at a respective mean and median of 1.3 and 0.26 ng/g fresh weight in 141 of 151 human milk samples collected 2002 to 2005 from primiparous Australian mothers, 100 samples had concentrations of 1.0 ng/g or less(4). Triclosan was detected in adipose, brain and liver tissue of 11 autopsy patients collected in 2002 from University Hospital of Antwerp, Belgium at <0.06-3.92, <0.06-0.23 and <0.06-24.80 ng/g wet weight, respectively(5).
相互作用Humans are commonly exposed to multiple environmental chemicals, including tetrabromobisphenol A (TBBPAa flame retardant), triclosan (an antimicrobial agent), and bisphenol A (BPApolycarbonate plastics). These chemicals are readily absorbed and may interact with each other. We sought to determine whether TBBPA, given alone or in combination with triclosan, can modulate the concentrations of BPA and 17bta-estradiol (E2). Female and male CF-1 mice were each given a subcutaneous injection of 0-27 mg TBBPA, with or without concurrent 0.33 mg triclosan, followed by dietary administration of 50 ug/kg body weight (14)C-BPA. Radioactivity was measured in blood serum and tissues through liquid scintillation counting. In subsequent experiments, female and male CF-1 mice were each given a subcutaneous injection of 0 or 1 mg TBBPA and E2 was measured in urine 2-12 hr after injection. Doses as low as 1mg TBBPA significantly elevated (14)C-BPA concentrations in the uterus and ovaries of femalesin the testes, epididymides, vesicular-coagulating glands, and preputial glands of malesand in blood serum, heart, lungs, and kidneys of both sexesurinary E2 concentrations were also elevated. Lower doses of TBBPA or triclosan that had no effects on their own elevated (14)C-BPA concentrations when the two substances were given concurrently. These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism.Atrazine is an herbicide with several known toxicologically relevant effects, including interactions with other chemicals. Atrazine increases the toxicity of several organophosphates and has been shown to reduce the toxicity of triclosan to Daphnia magna in a concentration dependent manner. Atrazine is a potent activator in vitro of the xenobiotic-sensing nuclear receptor, HR96, related to vertebrate constitutive androstane receptor (CAR) and pregnane X-receptor (PXR). RNA sequencing (RNAseq) was performed to determine if atrazine is inducing phase I-III detoxification enzymes in vivo, and estimate its potential for mixture interactions. RNAseq analysis demonstrates induction of glutathione S-transferases (GSTs), cytochrome P450s (CYPs), glucosyltransferases (UDPGTs), and xenobiotic transporters, of which several are verified by qPCR. Pathway analysis demonstrates changes in drug, glutathione, and sphingolipid metabolism, indicative of HR96 activation. Based on our RNAseq data, we hypothesized as to which environmentally relevant chemicals may show altered toxicity with co-exposure to atrazine. Acute toxicity tests were performed to determine individual LC50 and Hillslope values as were toxicity tests with binary mixtures containing atrazine. The observed mixture toxicity was compared with modeled mixture toxicity using the Computational Approach to the Toxicity Assessment of Mixtures (CATAM) to assess whether atrazine is exerting antagonism, additivity, or synergistic toxicity in accordance with our hypothesis. Atrazine-triclosan mixtures showed decreased toxicity as expectedatrazine-parathion, atrazine-endosulfan, and to a lesser extent atrazine-p-nonylphenol mixtures showed increased toxicity. In summary, exposure to atrazine activates HR96, and induces phase I-III detoxification genes that are likely responsible for mixture interactions.... The aim of the present study was to examine whether triclosan reduces the clinical symptoms on skin after exposure to nickel in an allergic patch test reaction (APR) model. 1% nickel sulfate was used for APR in 10 nickel-allergic females. The results showed that application of triclosan on skin reduced the APR symptoms from nickel in sensitized patients significantly (p<0.05) compared to the saline and alcohol solutions.... The aim of the present study was to examine whether triclosan has an effect on the inflammation in human skin caused by intradermal administration of histamine. 9 female volunteers participated in a double-blind study, and skin patch tests were performed in 2 series. In the 1st, the skin was pre-treated for 1 hr with triclosan before the histamine was applied. In the 2nd, the histamine reaction was elicited first and triclosan applied subsequently. The effect of triclosan on the wheals formed in the skin after histamine application was measured. It was found that triclosan reduced the size of the wheals markedly when triclosan was applied after the wheals were formed, and that pre-treatment of the skin had only a slight effect.... The effects of triclosan /were evaulated/ in the female Wistar rat following exposure for 21 days in the Endocrine Disruptor Screening Program pubertal protocol and the weanling uterotrophic assay (3-day exposure). In the pubertal study, triclosan advanced the age of onset of vaginal opening and increased uterine weight at 150 mg/kg, indicative of an estrogenic effect. In the uterotrophic assay, rats received oral doses of triclosan (1.18, 2.35, 4.69, 9.37, 18.75, 37.5, 75, 150, and 300 mg/kg) alone, 3 ug/kg ethinyl estradiol (EE), or triclosan (same doses as above) plus 3 ug/kg EE. Uterine weight was increased in the EE group (positive control) as compared with the control but was not affected by triclosan alone. However, there was a significant dose-dependent increase in the group cotreated with EE and triclosan (> or = 4.69 mg/kg) as compared with EE alone, indicating a potentiation of the estrogen response on uterine weight. This result was well correlated with potentiated estrogen-induced changes in uterine histology. Serum thyroid hormone concentrations were also suppressed by triclosan in this study, similar to other studies in the male and female rat. In conclusion, triclosan affected estrogen-mediated responses in the pubertal and weanling female rat and also suppressed thyroid hormone in both studies. The lowest effective concentrations in the rodent model are approximately 10 (for estrogen) and 40 (for thyroid hormone) times higher than the highest concentrations reported in human plasma.
生態毒性値EC50Species: Dunaliella tertiolecta (Algae)Conditions: staticConcentration: 3.55 ug/L for 96 hrEffect: decreased population cell densityLC50Species: Eisenia fetida (Earthworm) juvenile, mixed cultures of 6 species, mites, earthworms and springtailsdirect application (natural soil pH 5.8, 1.5% organic matter) 1836 umol/kg dry soilSpecies: Colinus virginianus (Bobwhite quail) age 13 daysdiet >5000 ppm for 8 daysLD50Species: Colinus virginianus (Northern Bobwhite Quail) age 21 weeksoral via capsule 825 mg/kg (95% confidence interval: 658-1079 mg/kg)For more Ecotoxicity Values (Complete) data for Triclosan (37 total), please visit the HSDB record page.
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 3500-20,000(2-3) indicate that triclosan is expected to have slight to no mobility in soil(SRC). The pKa of triclosan is 7.9(4), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of the anion from moist soil is not expected because anions do not volatilize(SRC). Volatilization of neutral triclosan from moist soil surfaces is not expected(SRC) given an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(6). Triclosan is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(6). Triclosan is persistent in soils with a primary degradation half-life of several months and degradation is a function of soil properties (texture, organic carbon, clay, pH) and incubation conditionsmethyl triclosan is the major biodegradation product when it does biodegrade(7). Triclosan had a photodegradation half-life of 17 days on dry loamy soil(8). The half-life of triclosan under field conditions has been reported as 13.2-32.5 days(9).TERRESTRIAL FATE: In loamy sand soil, after a 10 year simulation of turf grass irrigation using reclaimed water, triclosan was 35.20% degraded, 1.11% evaporated <0.01% leached and 63.51% was absorbed to soil(1). In sandy loam soil the respected percentages were 8.81%, 1.24%, <0.01% and 89.755%. The degradation half-life for triclosan in soil was reported as follows(1):[Table#6812]AQUATIC FATE: Based on a classification scheme(1), Koc values of 3500-20,000(2-3) indicate that triclosan is expected to adsorb to suspended solids and sediment(SRC). A pKa of 7.9(4) indicates triclosan will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces of the anion is not expected. Volatilization of neutral triclosan from water surfaces is not expected(5) based upon an estimated Henry's Law constant of 2.1X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(6). Triclosan is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(5). According to a classification scheme(7), BCFs of 2.7-90 measured in carp(8), suggest bioconcentration in aquatic organisms is low to moderate. Photolytic degradation of triclosan was experimentally measured in fresh and sea water with half-lives of 8 and 4 days, respectively(9). Triclosan dissipation in river water was studied in Cibolo Creek, TXupstream of the municipal treatment plant triclosan concentration was 34 ng/L, effluent concentration was 785 ng/L, concentration 200 m downstream (115 min travel time) was 431 ng/L, concentration 2000 m downstream (585 min travel time) was 223 ng/L, and concentration 8000 m downstream (1485 min travel time) was 104 ng/L(10). Because the source of triclosan is continuous, dissipation is expected to be due to biodegradation, sorption and photolysis, not dilution(10). Triclosan reached 0% of its Theoretical BOD in 4 weeks in the Japanese MITI test, indicating that biodegradation is not an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triclosan, which has an estimated vapor pressure of 4.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase triclosan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 24 hours(SRC), calculated from its rate constant of 1.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase triclosan may be removed from the air by wet or dry deposition(SRC). Triclosan does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
食品調査値Triclosan concentration in cow's milk was <20 ug/kg(1). Triclosan was not detected in raw, whole or skim cow's milk purchased from Spain and Moroccobut was detected in one of two semi-skim milk samples at 0.35 ug/kg(2). Triclosan was not detected in whole or half-skim goat's milk or powdered milk(2).
有害作用Dermatotoxin - PACD (photoallergic contact dermatitis).
暴露経路A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream. (A7866) Triclosan is rapidly absorbed and distributed in the human body (Sandborgh-Englund et al., 2006). Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.
Milk ConcentrationsTriclosan was detected in three of five randomly selected Swedish human milk samples at concentrations ranging from 60 to 300 ug/kg lipid weight(1). Triclosan was detected at a respective mean and median concentration of 1.3 and 0.26 ng/g fresh weight in 141 of 151 human milk samples collected 2002 to 2005 from primiparous Australian mothers, 100 samples had concentrations of 1.0 ng/g or less(2). Triclosan was detected in milk of nursing mothers approximately 6 weeks after delivery at 0.32-0.95 and <0.018-0.35 ng/g in exposed and controls, respectively, 12 weeks after delivery respective concentrations were 0.022-0.84 and <0.018-0.33 ng/g(3). Triclosan was detected in two of three human breast milk samples at 0.16 and 0.25 ug/kg(4). Triclosan concentration in cow's milk was <20 ug/kg(1). Triclosan was not detected in raw, whole or skim cow's milk purchased from Spain and Moroccobut was detected in one of two semi-skim milk samples at 0.35 ug/kg(4). Triclosan was not detected in whole or half-skim goat's milk or powdered milk(4).
毒性の概要Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION AND USE: Triclosan is a white to off-white crystalline powder. It is used as fungicide and bacteriostat. It is highly active against staphylococci and is used as an active agent in deodorants and antiseptic soaps. It is also used as material preservative for industrial and household plastics and textiles. HUMAN STUDIES: Fifty human subjects were treated with a 0.5% triclosan solution in a 1% soap solution. Triclosan was found not to be a sensitizer and the irritation potential depended on concentration. Tests also showed that triclosan was not a photosensitizing agent. Triclosan exposure might cause spontaneous abortionprobably through inhibition of estrogen sulfotransferase activity to produce placental thrombosis. In terms of estrogenic activity, triclosan displaced (3)H-estradiol from estrogen receptors (ER) of MCF7 human breast cancer cells and from recombinant human ER alpha/ER beta. In children, triclosan exposure was associated with allergic sensitization, especially inhalant and seasonal allergens, rather than food allergens. Current rhinitis was associated with the highest levels of triclosan, whereas no association was seen for current asthma. ANIMAL STUDIES: Triclosan was found to cause slight primary eye irritation when applied to the rabbit eye mucosa. Triclosan had a very low sensitization index in guinea pigs. Mice and rats administered triclosan intravenously at 10, 20 and 30 (rats only) mg/kg bw showed signs of slight cramps, exopthalmos (mice only), mydriasis (rats only), dyspnea, and ventral decubitus, with recovery by 24 to 48 hr after dosing. In an 18-month carcinogenicity bioassay in mice, 5 groups of male and female mice (70 mice/sex/dose) received triclosan in the diet at dose levels of 0, 10, 30, 100, or 200 mg/kg/day. Fifty mice/sex/dose received dietary triclosan for 18 months, while the remaining 20 mice/sex/dose received dietary triclosan for only 6 months, after which time these mice were sacrificed. After 18 months of exposure, a statistically significant increase in the incidence of hepatocellular adenoma and/or carcinoma was observed in male and female mice at 100 mg/kg/day triclosan and above. The incidence was dose-related in both sexes. In a developmental toxicity study in mice, triclosan was administered to 25 female mice/dose via the diet at target dose levels of 0, 10, 25, 75, or 350 mg/kg/day from days 6-15 of gestation. Maternal toxicity was observed at 75 mg/kg/day by increases in absolute and relative liver weight and tan areas in the liver of one dam. Developmental effects were noted at the 75 and 350 mg/kg/day target dose levels as increased incidence of variations (characterized as reversible irregular ossification of the skull at 75 and 350 mg/kg/day, and phalanges at 350 mg/kg/day). Decreased fetal weight was also observed 14 and 18% decrease at 75 and 350 mg/kg/day target dose levels, respectively). Triclosan decreased the synthesis of androgens followed by reduced sperm production in treated male rats. In rats, direct per oral pup exposure from postnatal day 3-16 to 50 or 150 mg triclosan/kg bw/day was performed. This exposure pointed to significant T4 reductions in 16 day old offspring in both dose groups. Triclosan was tested on Salmonella typhimurium strains TA1537, TA100, TA98, TA1535 and TA1538 with or without metabolic activation. There were no treatment-related increases in gene mutation at any dose. Dermal exposure to triclosan induces stimulation of the immune system in a murine model. ECOTOXICITY STUDIES: At environmentally relevant concentrations (<2 ug/L) it could cause a decline in the fish population. Triclosan in the aquatic environment may affect algal growth, chlorophyll synthesis, oxidative stress responses and cause biochemical alterations. Mature male western mosquitofish, Gambusia affinis, were exposed to triclosan concentrations of 100, 200, and 350 nM for 35 days. Vitellogenin mRNA expression was significantly elevated in the 350 nM triclosan treatment. Sperm counts in the same treatment group were significantly decreased. The mean hepatosomatic index in the 350 nM treatment group was significantly increased. This study demonstrates that triclosan has the potential to act as an endocrine disruptor in male mosquitofish. In the North American bullfrog, Rana catesbeiana, exposure to low levels of triclosan disrupts thyroid hormone-associated gene expression and can alter the rate of thyroid hormone-mediated postembryonic anuran development. Triclosan induced systemic toxic effects in C. elegans.At in-use concentrations, triclosan acts as a biocide, with multiple cytoplasmic and membrane targets. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to bacterial enoyl-acyl carrier protein reductase enzyme (ENR), which is encoded by the gene FabI. This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for reproducing and building cell membranes. Humans do not have an ENR enzyme, and thus are not affected.
Average Daily IntakeThe average daily intake of triclosan via breast milk in infants was calculated to be 1024 and 204 ng/day in Australia, based on the respective mean and median triclosan concentration in breast milk of 1.3 and 0.26 ng/g fresh weight(1).
生態毒性抜粋/AQUATIC SPECIES/ Triclosan (TCS) is an emerging contaminant of concern in environmental studies due to its potential adverse effects on fish behavior. Since avoidance has been shown to be a relevant behavioral endpoint, ... aims were: (i) to determine if TCS is able to trigger an avoidance response in Poecilia reticulata /guppy/(ii) to predict the population immediate decline (PID) caused by TCS exposure, by integrating lethality and avoidance responsesand (iii) to verify the overestimation of risk when mortality is assessed under forced exposure. Fish were exposed to TCS in a forced exposure system, to assess mortality, and to a TCS gradient in a non-forced exposure (NFE) system. Two NFE scenarios were simulated: (#1) a spatially permanent gradient, including low and high concentrationsand (#2) a scenario with high concentrations, simulating a local discharge. The fish avoided TCS concentrations as low as 0.2 ug/L (avoidance of 22%). The AC50 obtained from scenario #1 (8.04 ug/L) was about 15 times more sensitive than that from scenario #2 (118.4 ug/L). In general, up to the highest concentration tested (2000 ug/L), the PID was determined by the avoidance. Mortality from the forced exposure was overestimated (48 hr-LC50 of 1650 mg/L), relative to the NFE. The reduced mortality in a non-forced environment does not imply a lower effect, because part of the population is expected to disappear by moving towards favorable environments. TCS is a potential environmental disturber, since at environmentally relevant concentrations (<2 ug/L) it could cause a decline in the fish population./AQUATIC SPECIES/ Pharmaceutical and personal care products (PPCPs) are the environmental pollutants of growing concern. The aim of this study was to indicate the effects of typical PPCPs on the marsh frog Pelophylax ridibundus. We treated male frogs with waterborne ibuprofen (IBU, 250 ng/L), triclosan (TCS, 500 ng/L), or estrone (E1, 100 ng/L) for 14 days. Common vulnerability of the frogs was detected from dramatic decrease of Zn, total and metalated metallothionein (MT) concentrations, Zn/Cu ratio, the elevation of activity of glutathione-S-transferase, cathepsin D and DNA instability in the liver, the depletion of cholinesterase in the brain and cortisol in the blood plasma in all exposures. Nevertheless, lipofuscin concentration in the liver was always decreased. The groups were best distinguished by cytochrome P450 (CYP450) activity determined by ELISA. The exposure to IBU caused lesser damage, but elevated the levels of oxyradicals and glutathione (GSH and GSSG) and lysosomal membrane instability. Exposures to TCS and E1 provoked the endocrine disturbance (increased levels of vitellogenin and thyrotropin in blood plasma), decreased lactate dehydrogenase activity and increased level of pyruvate in the liver. TCS caused the increase of GSSG by 7.3 times and lactate levels. Only E1 lead to decrease of deiodinase activity in the liver, activation of CYP450 and caspase-3 and efflux of cathepsin D from lysosomes. Spectrophotometric and ELISA assays of MTs and CYP450 gave distinct results in E1-group. Broad disruption of the hormonal pathways caused by E1 could be of concern for the health status of frogs in their habitats./AQUATIC SPECIES/ Triclosan is a commonly used bactericide that survives several degradation steps in WWTP (wastewater treatment plants) and potentially reaches fluvial ecosystems. In Mediterranean areas, where water scarcity results in low dilution capacity, the potential environmental risk of triclosan is high. A set of experimental channels was used to examine the short-term effects of triclosan (from 0.05 to 500 ug/L) on biofilm algae and bacteria. Environmentally relevant concentrations of triclosan caused an increase of bacterial mortality with a no effect concentration (NEC) of 0.21 ug/L. Dead bacteria accounted for up to 85% of the total bacterial population at the highest concentration tested. The toxicity of triclosan was higher for bacteria than algae. Photosynthetic efficiency was inhibited with increasing triclosan concentrations (NEC=0.42 ug/L), and non-photochemical quenching mechanisms decreased. Diatom cell viability was also affected with increasing concentrations of triclosan. Algal toxicity may be a result of indirect effects on the biofilm toxicity, but the clear and progressive reduction observed in all the algal-related endpoints suggest the existence of direct effects of the bactericide. The toxicity detected on the co-occurring non-target components of the biofilm community, the capacity of triclosan to survive through WWTP processes and the low dilution capacity that characterizes Mediterranean systems extend the relevance of triclosan toxicity beyond bacteria in aquatic habitats./AQUATIC SPECIES/ This study exposed marine species to triclosan to examine effects primarily on survival and to investigate the formation of the degradation product, methyl-triclosan, in the estuarine environment. Acute toxicity was assessed using the bacterium Vibrio fischeri, the phytoplankton species Dunaliella tertiolecta, and three life stages of the grass shrimp Palaemonetes pugio. P. pugio larvae were more sensitive to triclosan than adult shrimp or embryos. Acute aqueous toxicity values (96 hr LC50) were 305 ug/L for adult shrimp, 154 ug/L for larvae, and 651 ug/L for embryos. The presence of sediment decreased triclosan toxicity in adult shrimp (24 hr LC50s were 620 ug/L with sediment, and 482 ug/L without sediment). The bacterium was more sensitive to triclosan than the grass shrimp, with a 15 min aqueous IC50 value of 53 ug/L and a 15 min spiked sediment IC50 value of 616 ug/kg. The phytoplankton species was the most sensitive species tested, with a 96 hr EC50 value of 3.55 ug/L. Adult grass shrimp were found to accumulate methyl-triclosan after a 14-day exposure to 100 ug/L triclosan, indicating formation of this metabolite in a seawater environment and its potential to bioaccumulate in higher organisms. Triclosan was detected in limited surface water sampling of Charleston Harbor, SC at a maximum concentration of 0.001 ug/L, substantially lower than the determined toxicity values. These findings suggest triclosan poses low acute toxicity risk to estuarine organismshowever, the potential for chronic, sublethal, and metabolite effects should be investigated.For more Ecotoxicity Excerpts (Complete) data for Triclosan (37 total), please visit the HSDB record page.
Plant ConcentrationsTriclosan was detected in algae from Pecan Creek, TX downstream of a waste water treatment plant at concentrations of 109 to 146 ppb, upstream of the plant triclosan was not detected (detection limit 10 ppb), samples were collected Sept 2-5, 2005(1).
水環境危害等級（WGK）2
TSCA 収載状態TSCA listed
RTECS 番号KO1100000
輸送番号（UN）UN 3077 9/PG 3
毒性LD50 orl-rat: 3700 mg/kg 26UZAB 6,245,68/70
税関コード29095000
危険文句（R）36/38-50/53-36/37/38
化審法(9)-381, (9)-922 優先評価化学物質
危険表示Xi,N
安全措置（S）26-39-46-60-61-24/25-22-36
危険等級9Aquatic Acute 1Aquatic Chronic 1Eye Irrit. 2Skin Irrit. 2
包装等級III
環境リスク評価5-クロロ-2-(2’,4’-ジクロロフェノキシ)フェノール(3380-34-5)
貯蔵分類11 - Combustible Solids
有害物質データ3380-34-5(Hazardous Substances Data)