Prezcobix
基本情報
- 標準SMILES
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@H]21)S(=O)(=O)c1ccc(N)cc1.CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1- InChIKey
CXORHDVSJFELCV-HWDLLDTBSA-N- 分子式
- C67H90N10O12S3
- 平均分子量
- 1,323.7 g/mol
- 単同位体質量
- 1,322.59018187
概要
Prezcobix and Prezcobix PED are prescription medicines approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV in adults and children 3 years of age and older who weigh at least 33 lb (15 kg) and meet certain requirements, as determined by a health care provider. Prezcobix and Prezcobix PED are always used in combination with other HIV medicines.
名称と識別子
- 優先名称
- Prezcobix
- IUPAC
- [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate;1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
名称と別名
PrezcobixDarunavir/cobicistatCobicistat / darunavirDarunavir / CobicistatCobicistat and darunavirDTXSID601336377darunavir-cobicistatCobicistat; darunavirDRV/COBIRefChem:56283CHEBI:90928DTXCID201766574
名称をさらに表示
Cobicistat/darunavirDarunavir and cobicistatSCHEMBL29363443S900006400
データベース識別子
- PubChem CID
- 57327017
- DTXSID
DTXSID601336377
物性
構造計算による物性
- 極性表面積
- 343 Ų
- 水素結合供与体数
- 6
- 水素結合受容体数
- 19
- 回転可能結合数
- 32
- 重原子数
- 92
- 形式電荷
- 0
- 複雑度
- 1,980
実験および物理化学的性質
Human DrugsFDA approved drugs -> Active ingredient
化学と産業
薬理情報
ATC Code
J - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
MeSH Pharmacological Classification
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP3A.
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