Lithium bis(trimethylsilyl)amide (HCID 57426343)

概要

structure in first source

名称と識別子

優先名称: Lithium bis(trimethylsilyl)amide
現地名: ヘキサメチルジシラザンリチウム
英語名: Lithium bis(trimethylsilyl)amide
分子式: C6H18LiNSi2
分子量: 167.33

名称と別名

Bis(trimethylsilyl)amidolithiumLithiumbis(trimethylsilyl)amineBis(trimethylsilyl)amido lithiumLi bis(TMS)ARefChem:924827(LiN(SiMe3)2)223-725-64039-32-1Disilazane, 1,1,1,3,3,3-hexamethyl-, lithium saltLithium bis(trimethylsilyl)amideLithium, (bis(trimethylsilyl)amino)-Lithiumbis(trimethylsilyl)amide

名称をさらに表示

ヘキサメチルジシラザンリチウム (29%テトラヒドロフラン溶液, 約1.6mol/L)1,1,1,3,3,3-ヘキサメチル-2-リチオプロパンジシラザンヘキサメチルプロパンジシラザン-2-イルリチウム1,1,1,3,3,3-ヘキサメチルプロパンジシラザン-2-イルリチウム2-リチオ-1,1,1,3,3,3-ヘキサメチルプロパンジシラザン[ビス(トリメチルシリル)アミノ]リチウムN-リチオビス(トリメチルシリル)アミン(1,1,1,3,3,3-ヘキサメチルプロパンジシラザン-2-イル)リチウム(リチオイミノ)ビス(トリメチルシラン)N-リチオ-N-(トリメチルシリル)-α,α,α-トリメチルシランアミンビス(トリメチルシリル)アミノリチウムリチオジ(トリメチルシリル)アミン2-リチオヘキサメチルプロパンジシラザンリチオイミノビス(トリメチルシラン)リチウムヘキサメチルジシラジドビス(トリメチルシリル)リチオアミン[ジ(トリメチルシリル)アミノ]リチウムリチオビス(トリメチルシリル)アミンリチウムビストリメチルシリルアミドリチウムビス(トリメチルシリル)アミドLIHMDSLHMDSLiHDMSLITHIUM HEXAMETHYLDISILAZANELithium 1,1,1,3,3,3-hexamethyldisilazideLITHIUM HEXAMETHYLDISILAZIDELithium bis(trimethylsilyl)amide solutionLiHMDS（1M）HMDS LiLiHMDS 1M in THF

lithium bis(trimethylsilyl)aminelithium HMDSlithiumhexamethyldisilazanelithium hexamethydisilazanelithium hexamethyidisilazanelithium hexamethyl disilazanelithium hexamethyl-disilazanelithium(hexamethyldisilazane)

データベース識別子

CAS: 4039-32-1
PubChem CID: 57426343
EC Number: 223-725-6

物性

構造計算による物性

極性表面積: 12 Å²
水素結合供与体数: 1
水素結合受容体数: 1
回転可能結合数: 2
重原子数: 10
形式電荷: 0
複雑度: 76.2

実験および物理化学的性質

Chemical ClassesMetals -> Metalloid Compounds (Silicon)

Physical Description · 2 件

Wet Solid

White powder; [Alfa Aesar MSDS]

物理化学的性質

融点: 73 °C · 73°C
沸点: 55 · 55-56 °C
比重(密度): 0.86 g/mL · 0.860 g/mL at 25 °C (lit.)
屈折率: 20 · n20/D 1.425(lit.)
闪点: 48 °F · 48 °F
貯蔵温度: 30 °C · Store below +30°C.
溶解性: 加水分解
外見: 粉
色: 白い
比重: 0.716 · 0.716
水溶解度: 加水分解
BRN: 3567910 · 3567910
主な用途: 電池前駆体触媒材料合成前駆体
InChI: 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChIKey: YNESATAKKCNGOF-UHFFFAOYSA-N
SMILES: [Li]N([Si](C)(C)C)[Si](C)(C)C
CAS データベース: 4039 · 4039-32-1(CAS DataBase Reference)
EPAの化学物質情報: 1 · Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1)

化学的性質

化学的特性light yellow to yellow crystalline powder

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H228 (43.9%): Flammable solid [Danger Flammable solids]

P210, P240, P241, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 198 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13861

1,1,1,3,3,3-Hexamethyldisilazane lithium salt: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryReacts violently with water evolving extremely flammable gases; Causes burns; [Alfa Aesar MSDS] See Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica. See Hexamethyldisilazane. See Lithium.

Hazard Classes and CategoriesFlam. Sol. 2 (43.9%)

毒性情報

Adverse EffectsDermatotoxin - Skin burns.

安全データ

F: 10-23
wgk: 3
tsca: TSCA listed
ridadr: UN 2925 4.1/PG 2
PRTR法: 1-392
hs_code: 29319090
risk_code: 11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19
化審法: 新規公示化学物質（2011年4月1日以降届出）
安衛法: 有機則第二種有機溶剤等変異原性物質
消防法: 危-4-1-II
hazard_code: F,C,N
safety_code: 9-16-26-29-33-36/37/39-45-61-62-57-43
hazard_class: 4.3
packing_group: II
Hazard Classifications: Eye Dam. 1Flam. Sol. 1Self-heat. 1Skin Corr. 1B
ストレージクラス: 4.2 - Pyrophoric and self-heating hazardous materials

化学と産業

用途と製造

UsesUsed as an intermediate; [ExPub: ECHA REACH Registrations]

U.S. Production2023: <50,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 件

Pharmaceutical and Medicine Manufacturing

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1): ACTIVE

応用分野 · 2 件

使用Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.

一般的な説明This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention.

調製方法

製造方法It is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.