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dl-イソプロテレノール·塩酸塩

(+-)-Isoproterenol hydrochloride

HCID 5807
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
51-30-9
標準SMILES
CC(C)NCC(O)c1ccc(O)c(O)c1.Cl
InChIKey
IROWCYIEJAOFOW-UHFFFAOYSA-N
分子式
C11H17NO3.ClH
平均分子量
247.72 g/mol
単同位体質量
247.0975211

概要

Isoproterenol hydrochloride is an odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. (NTP, 1992)

名称と識別子

優先名称
(+-)-Isoproterenol hydrochloride
IUPAC
4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride
現地名
dl-イソプロテレノール·塩酸塩
英語名
Isoproterenol hydrochloride
分子式
C11H18ClNO3
分子量
247.72

名称と別名

Isoprenaline hydrochloride51-30-9ISOPROTERENOL HYDROCHLORIDEAeroloneAerotrolVapo-IsoIsoproterenol HClAsthpulNorisodrine AerotrolDL-Isoproterenol hydrochloridedl-Isadrine hydrochlorideIsopropylarterenol hydrochloride
名称をさらに表示
(±)-イソプロテレノール·塩酸塩dl-塩酸イソプロテレノールdl-塩酸イソプレナリンdl-イソプロテレノール·塩酸塩(±)-イソプレナリン·塩酸塩(±)-イソプレナリン塩酸塩rac-4-[(R*)-1-ヒドロキシ-2-[(1-メチルエチル)アミノ]エチル]-1,2-ベンゼンジオール/塩酸,(1:1)ISOPRENALINE HCLTIMTEC-BB SBB003172dl-isadrinehydrochloridedl-isoprenalinehydrochloride-n-isopropyl-dl-noradrenalineHCl
Isoprenaline chlorideMistarelSuscardiaIsovon(+-)-Isoproterenol hydrochlorideIsoproterenol monohydrochloride(+-)-Isoprenaline hydrochlorideNCI-C55630

データベース識別子

CAS

物性

構造計算による物性

極性表面積
72.7 Ų
水素結合供与体数
5
水素結合受容体数
4
回転可能結合数
4
重原子数
16
形式電荷
0
複雑度
187

実験および物理化学的性質

Solubility · 2 件

Soluble (NTP, 1992)

>37.2 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point338 to 340 °F (NTP, 1992)
Physical DescriptionIsoproterenol hydrochloride is an odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air. (NTP, 1992)

物理化学的性質

融点
165 · 165-175 °C (dec.)(lit.)
CAS データベース
949 · 949-36-0(CAS DataBase Reference)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Other Safety InformationIMAP assessments - 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride: Human health tier I assessment
Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health Hazards · 1 件

SYMPTOMS: Symptoms of exposure to this compound may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating. (NTP, 1992)

Reactive GroupAlcohols and Polyols
Reactivity Profile · 1 件

An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Air and Water ReactionsMay be sensitive to exposure to air and light. (NTP, 1992). Water soluble.

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

ISOPROTERENOL HYDROCHLORIDE

Adrenergic beta-Agonists [MoA]; beta-Adrenergic Agonist [EPC]

MeSH Pharmacological Classification · 4 件

Drugs that selectively bind to and activate beta-adrenergic receptors.

Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

サプライヤー8 社

武汉易泰科技有限公司上海分公司18930552037 · [email protected]
北京绿百草科技发展有限公司010-61136123 · [email protected]
南京世洲生物科技有限公司13675144456 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]
金锦乐(湖南)化学有限公司18001959627(微信同号) 18001959627 · [email protected]
厦门盈融达化工有限公司+86-0592-6210733 · [email protected]
Dideu Industries Group Limited

関連反応

5 件
反応記録を作成
HRID 53100 の反応式
HRID 53100反応物としてuspto-grants-1997_04
HRID 726527 の反応式
HRID 726527反応物としてuspto-grants-1998_01
HRID 1379587 の反応式
HRID 1379587反応物としてuspto-grants-1997_09
HRID 1769224 の反応式
HRID 1769224反応物としてuspto-grants-1995_01
HRID 2256804 の反応式
HRID 2256804反応物としてuspto-grants-1997_08

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
51-30-9、949-36-0
PubChem CID
5807
DTXSID
DTXSID6025486
ChEMBL
CHEMBL1711
ChEBI
CHEBI:31453
UNII
DIA2A74855
EC Number
200-089-8、213-438-4
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Isoproterenol hydrochloride

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

安全データ

F
3-8-10
wgk
2
rtecs
DO1925000
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
+86-29-81148696 +86-15129568250 · [email protected]