基本情報
- CAS
51-63-8- 標準SMILES
C[C@H](N)Cc1ccccc1.C[C@H](N)Cc1ccccc1.O=S(=O)(O)O- InChIKey
PYHRZPFZZDCOPH-QXGOIDDHSA-N- 分子式
- C18H28N2O4S
- 平均分子量
- 368.5 g/mol
- 単同位体質量
- 368.17697855
概要
Dextroamphetamine Sulfate is the salt of the dextro-isomer of amphetamine and sympathomimetic amine with CNS stimulating properties. Dextroamphetamine sulphate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of narcolepsy and attention deficit hyperactivity disorder.
名称と識別子
- 優先名称
- Dextroamphetamine Sulfate
- IUPAC
- bis((2S)-1-phenylpropan-2-amine);sulfuric acid
名称と別名
Dextroamphetamine sulfateDexampexDextrostatFerndexDextroamphetamine sulphateDexamphetamine sulfateDexamphetamine sulphated-Amphetamine sulphateD-Amphetamine hemisulfate salt(+)-Amphetamine sulphateDexamfetamine sulfateDextroamphetamine Sulfate CII
名称をさらに表示
Dextro-Amphetamine SulfateDTXSID2057865JJ768O327Nd-alpha-Methylphenethylamine sulfateNSC-27104Dextro-beta-phenylisopropylamine sulfateDextro-alpha-methylphenethylamine sulfate(S)-alpha-Methylbenzeneethanamine sulfate
データベース識別子
- CAS
51-63-8- PubChem CID
- 5825
- DTXSID
DTXSID2057865- ChEMBL
CHEMBL3544971- UNII
- JJ768O327N
- EC Number
- 200-111-6
物性
構造計算による物性
- 極性表面積
- 135 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 6
- 回転可能結合数
- 4
- 重原子数
- 25
- 形式電荷
- 0
- 複雑度
- 166
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory InformationDextroamphetamine sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (97.9%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Dextroamphetamine sulfate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
化学と産業
薬理情報
FDA Pharmacological Classification
DEXTROAMPHETAMINE SULFATE
Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
関連反応
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化合物ノート
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