基本情報
- CAS
52-62-0- 標準SMILES
C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.O=C([O-])[C@H](O)[C@@H](O)C(=O)O.O=C([O-])[C@H](O)[C@@H](O)C(=O)O- InChIKey
HSMKTIKKPMTUQH-WBPXWQEISA-L- 分子式
- C23H42N2O12
- 平均分子量
- 538.6 g/mol
- 単同位体質量
- 538.27377478
概要
Pentolinium tartrate is the bitartrate salt of pentolinium. It has a role as an antihypertensive agent. It contains a pentolinium ion.
名称と識別子
- 優先名称
- Pentolinium Tartrate
- IUPAC
- 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium;bis((2R,3R)-2,3,4-trihydroxy-4-oxobutanoate)
名称と別名
PENTOLINIUM TARTRATEAnsolysenPentolonium tartrateRecurylTensilestPentalinium tartrateTartrato de pentolonioTartrate de pentoloniumPentolonii tartrasPentapyrrolidium bitartrate953357GACYPentamethylene-1,5-bis(1'-methylpyrrolidinium tartrate)
名称をさらに表示
NSC-759890CHEBI:55326pentolonio tartratopentolonium (cation)Tartrate, PentoliniumTartrate, PentoloniumRefChem:57597Pyrrolidinium, 1,1'-(1,5-pentanediyl)bis(1-methyl)-, salt with (R-(R*,R*))-2,3-dihydroxybutanedioic acid (1:2)
データベース識別子
- CAS
52-62-0- PubChem CID
- 5849
- ChEMBL
CHEMBL1318287- ChEBI
CHEBI:55326- UNII
- 953357GACY
物性
構造計算による物性
- 極性表面積
- 236 Ų
- 水素結合供与体数
- 6
- 水素結合受容体数
- 12
- 回転可能結合数
- 10
- 重原子数
- 37
- 形式電荷
- 0
- 複雑度
- 347
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
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