4-メチルアミノフェノール

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. /4-(Methylamino)phenol hemisulfate salt/

Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary. /4-(Methylamino)phenol hemisulfate salt/

Powder, alcohol-resistant foam, water spray, carbon dioxide.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Personal precautions: Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. /4-(Methylamino)phenol hemisulfate salt/

Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. /4-(Methylamino)phenol hemisulfate salt/

Methods for cleaning up: Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal. /4-(Methylamino)phenol hemisulfate salt/

Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers; if appropriate, moisten first to prevent dusting.

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material. /4-(Methylamino)phenol hemisulfate salt/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.

Handling: Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. /4-(Methylamino)phenol hemisulfate salt/

In case of skin contact: Wash off with soap and plenty of water. Consult a physician. /4-(Methylamino)phenol hemisulfate salt/

In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. /4-(Methylamino)phenol hemisulfate salt/

Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. /4-(Methylamino)phenol hemisulfate salt/

For more Preventive Measures (Complete) data for N-Methyl-4-aminophenol (7 total), please visit the HSDB record page.

LC50; Species: Goldfish; Concentration: 0.5 mg/L for 48 hr /Conditions of bioassay not specified in source/

LC50; Species: Oncorhynchus mykiss (Rainbow trout, weight 1.2-3.8 g, length 4.6-6.4 cm); Conditions: freshwater, flow through, 14.1-16.5 °C, pH 7.60-8.19, alkalinity 86 mg/L CaCO3, dissolved oxygen 5.6-9.4 mg/L; Concentration: 300 ug/L for 96 hr

LD50; Species: Oncorhynchus mykiss (Rainbow trout, weight 9.1-43.2 g, length 7.9-9.6 cm) oral (by gavage) 0.72 mmol/kg

LD50; Species: Oncorhynchus mykiss (Rainbow trout, weight 9.0-30.4 g, length 7.0-9.9 cm) ip 0.58 mmol/kg

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 110(SRC), determined from a structure estimation method(2), indicates that N-methyl-4-aminophenol is expected to have high mobility in soil(SRC). Volatilization of N-methyl-4-aminophenol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). N-Methyl-4-aminophenol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.1X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2009).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 110(SRC), determined from a structure estimation method(2), indicates that N-methyl-4-aminophenol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 4.4X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from an estimated log Kow of 0.79(SRC) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aromatic amines in the water column may be susceptible to significant photooxidation via hydroxyl and peroxy radicals; half-lives for these photooxidations may be on the order of 19-30 sunlight hours(7). Biodegradation data for N-methyl-4-aminophenol were not available(SRC, 2009).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), N-methyl-4-aminophenol, which has an estimated vapor pressure of 3.07X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase N-methyl-4-aminophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.9 hours(SRC), calculated from its rate constant of 5.6X10-11 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). N-Methyl-4-aminophenol contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC); typical half-lives for hydroxyl radical and peroxy radical reactions are on the order of 19-30 sunlight hours(5).

/AQUATIC SPECIES/ The cytotoxicity of 12 chemicals to rainbow trout (Salmo gairdneri) cells (RTG-2) was determined in culture. The indicator of cytotoxicity was the inability of cells to attach to a growth surface after chemical exposure. From most toxic to least toxic, these chemicals were pentachlorophenol, p-methylaminophenol, 2,4-dichlorophenol, p-chlorophenol, p-cyanophenol, p-nitrophenol, benzene, p-methylphenol, aniline, phenol, p-methoxyphenol, and 1,2,4-trichlorobenzene. Cytotoxicity was significantly correlated to systemic toxicity in rainbow trout.

Redness.

Redness. Pain.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of N-methyl-4-aminophenol can be estimated to be 110(SRC). According to a classification scheme(2), this estimated Koc value suggests that N-methyl-4-aminophenol is expected to have high mobility in soil.

/SIGNS AND SYMPTOMS/ Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood, resulting in lesions of blood cells.

/SIGNS AND SYMPTOMS/ N-Methyl-p-aminophenol causes a persistence of allergic dermatitis.

/SURVEILLANCE/ During the period January 1980-June 1981, an investigation was made of skin diseases among employees of a film laboratory. The investigation was carried out in 5 stages. (I) Questionnaire (II) Clinical examination and interview with all employees who stated that they had had skin disease at some time (III) Patch testing at the laboratory of all cases of suspected occupational dermatoses, and control tests in hospital of 200 non-exposed eczema patients (IV) Investigation of protective gloves by patch testing and in a chemical bath (V) Allergy test on guinea pigs (GPMT) of one agent (PBA-1). The firm had 114 employees and the questionnaire was answered by 103. Altogether 43 persons at some time had been exposed to chemicals in their work, and 21 of them had had occupational dermatoses. In 12 cases, contact allergy was found to one or more of the photographic chemicals CD-2, CD-3, Metol and PBA-1. GPMT with PBA-1 showed it to be a potent sensitizer. The color developing agents may also give rise to lichenoid reactions and 2 such cases were seen in this investigation. Other causes of occupational dermatoses are indicated, as well as the occurrence of non-occupational skin diseases.

AEROBIC: The BOD of a five-day BOD test was 0.2 with a BOD/COD ratio of 0.17 for 4-methylaminophenol sulfate, a compound similar to 4-methylaminophenol. This salt proved to be strongly inhibitory to an unacclimated system at concentrations as low as 50 mg/L; acclimation of the biomass to the compound eliminated any inhibitory effects. The data indicated biodegradation of 4-methylaminophenol sulfate proceeded at a moderate rate(1). /4-Methylaminophenol sulfate/