Tetraethylammonium Chloride (HCID 5946)

概要

Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.

名称と識別子

優先名称: Tetraethylammonium Chloride
IUPAC: tetraethylazanium chloride
現地名: テトラエチルアンモニウムクロリド
英語名: Tetraethylammonium Chloride
分子式: C8H20ClN
分子量: 165.7

名称と別名

TETRAETHYLAMMONIUM CHLORIDE56-34-8Etamon chlorideTea chlorideTEACN,N,N-Triethylethanaminium chlorideEthanaminium, N,N,N-triethyl-, chloridetetraethylazanium;chlorideDTXSID6041137CHEBI:781618B82Z83XNNDTXCID4021137

名称をさらに表示

テトラエチルアンモニウムクロリドN,N,N-トリエチルエタンアミニウム·クロリドテトラエチルアンモニウム·クロリドテトラエチルアミニウム·クロリド塩化エタモン塩化テトラエチルアンモニウムエタモンクロリドテトラエチルアンモニウムクロリド塩化テトラエチルアンモニウム塩化物クロライド塩化テトラエチルアンモニウム水和物塩化テトラエチルアンモニウム一水和物テトラエチルアンモニウム=クロリド塩化テトラエチルアンモニウム水和物TetraethylammoniumtetraethylazaniuM chlorideSKL1479N2,2,2,2Clammonium chLEthamon chlorideTetraethylammonium choride

RefChem:188563Chloride, Tetraethylammonium200-267-5Tetraethyl ammonium chloridetetraethylammoniumchlorideEt4NClTetraethylammonium (chloride)EINECS 200-267-5

データベース識別子

CAS: 56-34-8
PubChem CID: 5946
DTXSID: DTXSID6041137
ChEMBL: CHEMBL434435
ChEBI: CHEBI:78161
UNII: 8B82Z83XNN
EC Number: 200-267-5

物性

構造計算による物性

極性表面積: 0 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 4
重原子数: 10
形式電荷: 0
複雑度: 47.5

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Quaternary Amines

Density1.08 @25 °C

Solubility20.3 [ug/mL] (The mean of the results at pH 7.4)

Vapor Pressure0.00000308 [mmHg]

Physical Description · 2 件

Liquid

Deliquescent solid; [Merck Index] Colorless or light yellow hygroscopic crystals; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 39 °C · 39°C
沸点: 273.32 °C · 273.32°C (rough estimate)
比重(密度): 1.08 · 1.08
屈折率: 1.548 · 1.5480 (estimate)
貯蔵温度: Inert atmosphere,Room Temperature
溶解性: 0.1 g/mL、透明、無色 · メタノール: 0.1 g/mL、透明、無色
外見: 結晶性粉末
色: 白色～淡黄色
PH: 4 to · 4.0 to 7.0(50g/L, 25℃)
由来生物: synthetic (organic)
水溶解度: 水、エタノール、クロロホルム、アセトンに可溶
Merck: 14 · 14,9200
BRN: 3563247 · 3563247
安定性: 安定。強力な酸化剤とは相容れない。湿気から保護してください。
InChI: 1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChIKey: YMBCJWGVCUEGHA-UHFFFAOYSA-M
SMILES: [Cl-].CC[N+](CC)(CC)CC
CAS データベース: 56 · 56-34-8(CAS DataBase Reference)
EPAの化学物質情報: Tetraethylammonium chloride (56-34-8)

化学的性質

化学的特性Tetraethylammonium Chloride is a white crystalline powder. The solubility is 1000000 mg/L at 25 °C.

安全と法規制

GHS分類

GHS Classification · 6 件

Warning

H302 (25.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 103 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

H320: Causes eye irritation [Warning Serious eye damage/eye irritation]

危険有害性情報

Regulatory Information · 4 件

Chemical: Ethanaminium, N,N,N-triethyl-, chloride (1:1)

Ethanaminium, N,N,N-triethyl-, chloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, N,N,N-triethyl-, chloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 06-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20036

Ethanaminium, N,N,N-triethyl-, chloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Tetraethylammonium salts: Human health tier II assessment

Hazards Summary · 1 件

Causes somnolence, tremor, and muscle weakness in oral, intraperitoneal, and intramuscular lethal-dose studies of mice and rats; Human intravenous injection of 5 mg/kg causes paresthesias, mydriasis, and ptosis; [RTECS] A skin and strong eye irritant; Targets the heart and CNS; [Sigma-Aldrich MSDS] See Tetraethylammonium bromide.

Hazard Classes and Categories · 2 件

Acute Tox. 4 (25.2%)

Eye irritation - category 2B

安全と保護具

Protective Action Criteria (PAC) · 3 件

0.55 [mg/m3]

6.0 [mg/m3]

30 [mg/m3]

毒性情報

Adverse EffectsNeurotoxin - Other CNS neurotoxin

安全データ

F: 3-10
wgk: 3
tsca: TSCA listed
rtecs: BS6125000
毒性: LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)
hs_code: 29239000
risk_code: 22-36/37/38
化審法: (2)-186
hazard_code: Xn,Xi
safety_code: 26-36-37/39
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

用途と製造

UsesUsed as a catalyst (dehydrogenation and polymerization) and electrolyte (membrane transport studies); [Merck Index]

U.S. Production2023: 1,000,000 - <5,000,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 件

All Other Basic Organic Chemical Manufacturing

Ethanaminium, N,N,N-triethyl-, chloride (1:1): ACTIVE

応用分野 · 3 件

用途有機合成原料、触媒など。

使用Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.

一般的な説明Visit our Sensor Applications portal to learn more.

調製方法 · 1 件

純化方法Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]

上流・下流製品情報

下流製品

ブチルキサントゲン酸カリウム 2-クロロ-1H-ピロロ[2,3-D]ピリミジン 6-(ベンジルオキシ)-1H-プリン-2-アミンテトラエチルアンモニウムトリフルオロメタンスルホナートジクロロ(1,5-シクロオクタジエン)白金(II)

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

補足説明 · 1 件

定義ChEBI: Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.