テトラエチルアンモニウムクロリド
Tetraethylammonium Chloride
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基本情報
- CAS
56-34-8- 標準SMILES
CC[N+](CC)(CC)CC.[Cl-]- InChIKey
YMBCJWGVCUEGHA-UHFFFAOYSA-M- 分子式
- C8H20N.Cl
- 平均分子量
- 165.7 g/mol
- 単同位体質量
- 165.12842732
概要
Tetraethylammonium chloride is a quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. It has a role as a potassium channel blocker. It is a quaternary ammonium salt and an organic chloride salt. It contains a tetraethylammonium.
名称と識別子
- 優先名称
- Tetraethylammonium Chloride
- IUPAC
- tetraethylazanium chloride
- 現地名
- テトラエチルアンモニウムクロリド
- 英語名
- Tetraethylammonium Chloride
- 分子式
- C8H20ClN
- 分子量
- 165.7
名称と別名
TETRAETHYLAMMONIUM CHLORIDE56-34-8Etamon chlorideTea chlorideTEACN,N,N-Triethylethanaminium chlorideEthanaminium, N,N,N-triethyl-, chloridetetraethylazanium;chlorideDTXSID6041137CHEBI:781618B82Z83XNNDTXCID4021137
名称をさらに表示
テトラエチルアンモニウムクロリドN,N,N-トリエチルエタンアミニウム·クロリドテトラエチルアンモニウム·クロリドテトラエチルアミニウム·クロリド塩化エタモン塩化テトラエチルアンモニウムエタモンクロリドテトラエチルアンモニウム クロリド塩化テトラエチルアンモニウム 塩化物 クロライド塩化テトラエチルアンモニウム水和物塩化テトラエチルアンモニウム一水和物テトラエチルアンモニウム=クロリド塩化テトラエチルアンモニウム 水和物TetraethylammoniumtetraethylazaniuM chlorideSKL1479N2,2,2,2Clammonium chLEthamon chlorideTetraethylammonium choride
RefChem:188563Chloride, Tetraethylammonium200-267-5Tetraethyl ammonium chloridetetraethylammoniumchlorideEt4NClTetraethylammonium (chloride)EINECS 200-267-5
データベース識別子
- CAS
56-34-8- PubChem CID
- 5946
- DTXSID
DTXSID6041137- ChEMBL
CHEMBL434435- ChEBI
CHEBI:78161- UNII
- 8B82Z83XNN
- EC Number
- 200-267-5
物性
構造計算による物性補完中
- 極性表面積
- 0 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 1
- 回転可能結合数
- 4
- 重原子数
- 10
- 形式電荷
- 0
- 複雑度
- 47.5
実験および物理化学的性質
Chemical ClassesNitrogen Compounds -> Quaternary Amines
Density1.08 @25 °C
Solubility20.3 [ug/mL] (The mean of the results at pH 7.4)
Vapor Pressure0.00000308 [mmHg]
Physical Description
Liquid
Deliquescent solid; [Merck Index] Colorless or light yellow hygroscopic crystals; [Sigma-Aldrich MSDS]
物理化学的性質
- 融点
- 39 °C · 39°C
- 沸点
- 273.32 °C · 273.32°C (rough estimate)
- 比重(密度)
- 1.08 · 1.08
- 屈折率
- 1.548 · 1.5480 (estimate)
- 貯蔵温度
- Inert atmosphere,Room Temperature
- 溶解性
- 0.1 g/mL、透明、無色 · メタノール: 0.1 g/mL、透明、無色
- 外見
- 結晶性粉末
- 色
- 白色～淡黄色
- PH
- 4 to · 4.0 to 7.0(50g/L, 25℃)
- 由来生物
- synthetic (organic)
- 水溶解度
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H302 (25.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 103 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H320: Causes eye irritation [Warning Serious eye damage/eye irritation]
危険有害性情報
Regulatory Information
Chemical: Ethanaminium, N,N,N-triethyl-, chloride (1:1)
Ethanaminium, N,N,N-triethyl-, chloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, N,N,N-triethyl-, chloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 06-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20036
Ethanaminium, N,N,N-triethyl-, chloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Tetraethylammonium salts: Human health tier II assessment
Hazards Summary
Causes somnolence, tremor, and muscle weakness in oral, intraperitoneal, and intramuscular lethal-dose studies of mice and rats; Human intravenous injection of 5 mg/kg causes paresthesias, mydriasis, and ptosis; [RTECS] A skin and strong eye irritant; Targets the heart and CNS; [Sigma-Aldrich MSDS] See Tetraethylammonium bromide.
Hazard Classes and Categories
Acute Tox. 4 (25.2%)
Eye irritation - category 2B
化学と産業
薬理情報
MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
用途と製造
UsesUsed as a catalyst (dehydrogenation and polymerization) and electrolyte (membrane transport studies); [Merck Index]
U.S. Production2023: 1,000,000 - <5,000,000 lb
Industry UsesIntermediate
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
Ethanaminium, N,N,N-triethyl-, chloride (1:1): ACTIVE
応用分野
用途有機合成原料、触媒など。
使用Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions.
一般的な説明Visit our Sensor Applications portal to learn more.
調製方法
純化方法Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]
関連反応
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化合物ノート
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