ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
化工社オープンプロジェクト:[email protected]AIアクセス:llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.7.8
  1. ホーム
  2. /化合物

テポキサリン

Tepoxalin

HCID 59757
ノート反応
基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
103475-41-8
標準SMILES
COc1ccc(-n2nc(CCC(=O)N(C)O)cc2-c2ccc(Cl)cc2)cc1
InChIKey
XYKWNRUXCOIMFZ-UHFFFAOYSA-N
分子式
C20H20ClN3O3
平均分子量
385.8 g/mol
単同位体質量
385.1193192

名称と識別子

優先名称
Tepoxalin
IUPAC
3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
現地名
テポキサリン
英語名
Tepoxalin
分子式
C20H20ClN3O3
分子量
385.849

名称と別名

TEPOXALIN103475-41-8TepoxalineZubrinOrf-20485ORF 20485TepoxalinaRWJ 20485Tepoxalinum5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamideRWJ-20485DTXSID1057610
名称をさらに表示
5-(4-クロロフェニル)-N-ヒドロキシ-1-(4-メトキシフェニル)-N-メチル-1H-ピラゾール-3-プロパンアミドテポキサリン3-[1-(4-メトキシフェニル)-5-(4-クロロフェニル)-1H-ピラゾール-3-イル]-N-ヒドロキシ-N-メチルプロパンアミド3-[5-(4-クロロフェニル)-1-(4-メトキシフェニル)-1H-ピラゾール-3-イル]-N-ヒドロキシ-N-メチルプロパンアミドepoxalinTepoxalin, 10 mM in DMSOinhibit,Lipoxygenase,LOX,Inhibitor,COX,Tepoxalin,Cyclooxygenase3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-N-hydroxy-N-methylpropanamide3-[1-(4-Methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-TZ4OX61974DTXCID5031399CHEBI:76277Zubrin Rapidly-Disintegrating Tablets3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl)-N-hydroxy-N-methylpropanamide

データベース識別子

CAS
103475-41-8
PubChem CID
59757
DTXSID
DTXSID1057610
ChEMBL
CHEMBL316040
ChEBI
CHEBI:76277
UNII
TZ4OX61974
EC Number
638-877-2
Nikkaji
J357.517I

物性

構造計算による物性

XLogP
3.4
極性表面積
67.6 Ų
水素結合供与体数
1
水素結合受容体数
4
回転可能結合数
6
重原子数
27
形式電荷
0
複雑度
479

物理化学的性質

融点
124 · 124-126°
貯蔵温度
Hygroscopic, Refrigerator, Under Inert Atmosphere
溶解性
DMSO(少量)、メタノール(少量)
外見
個体
色
白色~薄茶色
安定性
吸湿性

化学的性質

化学的特性Off-White Solid

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 5 件

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 11 reports by companies from 1 notifications to the ECHA C&L Inventory.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationTepoxalin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)

法規制情報

Regulatory InformationTepoxalin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

安全データ

危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード H302

化学と産業

薬理情報

ATC CodeQM - Musculo-skeletal system;QM01 - Antiinflammatory and antirheumatic products;QM01A - Antiinflammatory and antirheumatic products, non-steroids;QM01AE - Propionic acid derivatives;QM01AE92 - Tepoxalin
MeSH Pharmacological Classification · 2 件

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

用途と製造

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
応用分野 · 1 件

使用Tepoxalin is non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties approved for veterinary use. It has inhibitory effect on cyclooxygenase and 5-lipxygenase activity a s well as inhibiting the production of cytokines in peripheral cells outside the CNS.

上流・下流製品情報

上流原料

Benzenehexanamide, 4-chloro-N-hydroxy-N-methyl-γ,ε-dioxo-2(3H)-Furanone, 5-[2-(4-chlorophenyl)-2-oxoethylidene]dihydro-3-[5-(4-クロロフェニル)-1-(4-メトキシフェニル)-1H-ピラゾール-3-イル]プロパン酸6-(4-chlorophenyl)-4,6-dioxohexanoic acidN-メチルヒドロキシルアミン 塩酸塩水和物4-メトキシフェニルヒドラジン塩酸塩オキサリルクロリド

サプライヤー52 社

陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Aladdin Scientific[email protected]
上海波以尔化工有限公司[email protected]
芷威(上海)化学科技有限公司021-20221225 13917446399 · [email protected]
梯希爱(上海)化工贸易有限公司021-61109150 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
Shanghai Hanhong Scientific Co., Ltd.+undefined17612118332 · [email protected]
上海伯韵医药科技有限公司13817873692 · [email protected]
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
上海贺康生物技术有限公司17721021104 18939837085 · [email protected]
上海毕得医药科技股份有限公司400-164-7117 18317119277 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
上海裕英生物医药科技有限公司021-50158063 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海皓之翔生物科技有限公司(原上海拓青化工有限公司)526763801 13301653310 · [email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +86-15355479329 · [email protected]
安耐吉化学&3A(安徽泽升科技股份有限公司)400-0056266 · [email protected]
上海德轩医药科技有限公司[email protected] · [email protected]
艾吉析科技(上海)有限公司17717235263 17717235263 · [email protected]
上海药禾平生物医药科技有限公司57540919 13120888836 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
武汉沃格达生物科技有限公司15071299552 · [email protected]
上海珀法姆医药科技有限公司+86 18721201413 · [email protected]
苏州爱玛特生物科技有限公司0512-56316828 400-867-5858;400-867-5858 · [email protected]
上海相辉医药科技有限公司[email protected]
上海泰坦科技股份有限公司13023226327 · [email protected]
上海臻励生物科技有限公司021-16621358918; 18516310516;16621358918;13045646768 · [email protected]
career henan chemical co+86-0371-86658258 · [email protected]
南京克罗托鲁宁医药科技有限公司13382066392
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
湖北摆渡化学有限公司027-59106051 13627137652 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
Nanjing Doge Biomedical Technology Co., Ltd+86-25-58227606 +86-15305155328 · [email protected]
Wuhan Topule Biopharmaceutical Co., Ltd+86-18327326525 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
湖北拓邦化工有限公司027-59106185 13986192185 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 18917919676 · [email protected]
重庆卡兰医药有限公司[email protected]
上海相辉医药科技有限公司13611835272 13611835272 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]
補足説明 · 1 件

定義ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the contr l of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.

関連反応

5 件
反応記録を作成
HRID 967353 の反応式
HRID 967353反応物としてuspto-grants-2005_10
HRID 967356 の反応式
HRID 967356生成物としてuspto-grants-2005_10
HRID 1166587 の反応式
HRID 1166587反応物としてuspto-grants-2003_09
HRID 1296826 の反応式
HRID 1296826反応物としてuspto-grants-2007_07
HRID 1934854 の反応式
HRID 1934854反応物としてuspto-grants-2002_05

化合物ノート

読み込み中…

このページの内容基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート