スルファミン酸
アミド硫酸 · スルファミン酸 · スルホアミン · スルファミド酸 · アミド硫酸 CRM3004-A · スルファミン酸(アミド硫酸) · 0.1MOL/Lアミド硫酸溶液(N/10) · アミド硫酸 CRM3004‐A
識別子と物理属性
| CAS No. | 5329-14-6 |
|---|---|
| 分子式 | H3NO3S |
| 平均分子量 | 97.1 g/mol |
| 単同位体質量 | 96.98336413 g/mol |
| SMILES | NS(=O)(=O)O |
| InChIKey | IIACRCGMVDHOTQ-UHFFFAOYSA-N |
| PubChem CID | 5987 |
| ChEBI | CHEBI:9330 |
| EC No. | 226-218-8 |
| DTXSID | DTXSID6034005 |
| 現地名 | スルファミン酸 |
化学・物理的性質
| XLogP | -1.6 |
|---|---|
| 極性表面積 | 88.8 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 4 |
| 回転可能結合数 | 0 |
| 重原子数 | 5 |
| 形式電荷 | 0 |
| 複雑度 | 92 |
| pH | 1N, pH=0.410.75N, pH=0.50.5N, pH=0.630.25N, pH=0.870.1N, pH=1.180.05N, pH=1.410.01N, pH=2.021.2 (10g/l, H2O) |
| LogP（分配係数） | 0.10 |
| 臭い | ODORLESS無臭 |
| 密度 | 2.15Relative density (water = 1): 2.12.15 @25 °C2.151 g/cm3 at 25 °C |
| Color/Form | ORTHORHOMBIC CRYSTALSWHITE CRYSTALLINE SOLIDGranular grade is off-white in color |
| 溶解度 | SPARINGLY SOL IN ALC, METHANOLSLIGHTLY SOL IN ACETONEINSOL IN ETHERFREELY SOL IN NITROGENOUS BASES AND IN NITROGEN CONTAINING ORG SOLVENTSINSOL IN CARBON DISULFIDE & CARBON TETRACHLORIDE12.8 wt% in water at 0 °C17.57 wt% in water at 20 °C22.77 wt% in water at 40 °C0.1667 wt% in formamide at 25 °C0.0412 wt% in methanol at 25 °C0.0167 wt% in ethanol (2% benzene) at 25 °C0.0040 wt% in acetone at 25 °C0.0001 wt% in ether at 25 °Cwater solubility = 1.47X10+5 mg/l @ 0 °C147 mg/mL at 0 °CSolubility in water at 20 °C: freely soluble水: 213g/L at 20°C146.8g/L（20℃） |
| Corrosivity | H2SO4 (3wt%) and HCl (3wt%) are 2.6 and 4.2 times more corrosive, respectively, than a 3 wt% solution of sulfamic acid on 1010 steel. On the same scale, H2SO4 and HCl (3wt% solutions) are 1.5 and 6.7, respectively, times more corrosive on copper1.5 and 2.8 more corrosive on brass4.0 and 7.0 more corrosive on bronze0.6 and 5.3 more corrosive on aluminum. |
| 沸点 | DECOMP @ BOILING POINT-520.47°C (estimate) |
| Decomposition | WHEN HEATED TO DECOMP, IT EMITS HIGHLY TOXIC FUMES OF /SULFUR OXIDES & HYDROGEN CHLORIDE/.~205 °C |
| 融点 | Melting point equals 205 °C215-225 °C (dec.) (lit.) |
| Heat of Combustion | 1.53x10+7 J/kmol |
| Physical Description | Sulfamic acid appears as a white crystalline solid. Density 2.1 g / cm3. Melting point 205 °C. Combustible. Irritates skin, eyes, and mucous membranes. Low toxicity. Used to make dyes and other chemicals.LiquidOther SolidDry PowderLarge CrystalsCBIWhite crystals[CAMEO]ODOURLESS COLOURLESS CRYSTALS OR POWDER. |
| 蒸気圧 | 0.8Pa at 20℃ |
| 屈折率 | 1.553 |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | 結晶または結晶性粉末 |
| pKa（酸解離定数） | -8.53±0.27(Predicted) |
| 色 | 白い |
| Merck | 14,8921 |
| 安定性 | 安定。 |
| 主な用途 | 環境食品および飲料一般的な分析工業品質管理医薬品 |
| InChI | 1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) |
| InChIKey | IIACRCGMVDHOTQ-UHFFFAOYSA-N |
| SMILES | NS(O)(=O)=O |
| LogP（分配係数） | 0 at 20℃ |
| CAS データベース | 5329-14-6(CAS DataBase Reference) |
| NISTの化学物質情報 | Sulfamic acid(5329-14-6) |
| EPAの化学物質情報 | Sulfamic acid (5329-14-6) |
化学的特性
Sulfamic acid is a white orthorhombic flaky crystal, odorless, non-volatile and non-hygroscopic. Soluble in water and liquid ammonia, slightly soluble in methanol, insoluble in ethanol and ether, also insoluble in carbon disulfide and liquid sulfur dioxide. Its aqueous solution has the same strong acid properties as hydrochloric acid and sulfuric acid, but its corrosiveness to metals is much lower than that of hydrochloric acid. The toxicity is extremely small, but it should not be in contact with the skin for a long time, and it should not enter the eyes.
化学性质
色透明の斜方晶系の結晶で，揮发性も吸湿性もない。水，ホルムアルデヒドに溶解し，メタノール，エタノールに少し溶解する。水溶液中では電離度が大きく，硫酸，塩酸，硝酸に匹敵する強酸性を示すが，有機物に対する腐食性はなく，その塩類は水に溶解する。
安全性と法規制
| GHS 分類 | WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 2.7% (104 of 3920) of reports. |
|---|---|
| 規制情報 | Chemical: Sulfamic acidSulfamic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sulfamic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14842Status: Active Update: 11-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22327Sulfamic acid: HSNO Approval: HSR001549 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| その他の安全情報 | IMAP assessments - Sulfamic acid: Human health tier I assessmentIMAP assessments - Sulfamic acid: Environment tier I assessment |
| 輸送ラベル（DOT） | Corrosive |
| 火災危険 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion or sodium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2024)· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.· Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). |
用途
解説
スルファミン酸とは、のヒドロキシ基をアミノ基に置換して得られる構造を有する水溶性の化学物質です。 アミド硫酸とも呼ばれます。常温では白色の固体で、加熱すると205°Cで分解します。に溶けにくいです。固体は吸湿性がなく、純品を得やすいです。スルファミン酸はと発煙硫酸を用いて合成できます。 スルファミン酸は亜硝酸と反応すると、窒素ガスを生じます。還元剤として働くため、硝酸との反応では亜酸化窒素を生成可能です。
用途
亜硝酸等の還元剤、有機、無機合成原料。
用途
亜硝酸除去剤、還元剤、有機合成触媒。
用途
めっき用浴PH調整剤、アルカリ滴定の標準溶液、塩素安定剤(水泳用プール等)、酸やニトリルの洗浄用、硝酸規定液の標定、試験研究用薬品、人口甘味料原料、医薬原料、酸性洗浄剤
使用
Sulfamic acid is widely used in electroplating, hard-water scale reremovers, acidic cleaning agent, chlorine stabilizers, sulfonating agents, denitrification agents, disinfectants, flame retardants, herbicides, artificial sweeteners and catalysts.Sulfamic acid is a precursor to sweet-tasting compounds. Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate.Sulfamic acid is a water-soluble, moderately strong acid. An intermediate between sulfuric acid and sulfamide, it can be used as a precursor to sweet-tasting compounds, a therapeutic drug component, an acidic cleaning agent, and a catalyst for esterification.
一般的な説明
Sulfamic acid appears as a white crystalline solid. Density 2.1 g / cm3. Melting point 205°C. Combustible. Irritates skin, eyes, and mucous membranes. Low toxicity. Used to make dyes and other chemicals. It is used as a raw material for the preparation of a synthetic sweetener i.e, sodium cyclohexylsulfamate.
使用用途
スルファミン酸は、人工甘味料であるチクロ (英: Cyclamate) の原料です。別の人工甘味料であるアセスルファムカリウムも、スルファミン酸から合成されます。 スルファミン酸と2-エチルヘキサノールの反応では、硫酸2-エチルヘキシルを合成可能です。硫酸2-エチルヘキシルは、綿のシルケット加工で湿潤剤として使用されます。また、酸塩基滴定では標準物質として用いられます。具体的には、水溶液の濃度を正確に求めるため、標定に利用可能です。 さらにスルファミン酸は、金属やセラミックの洗浄剤や錆び落としに使用されます。の代わりにスルファミン酸が主成分のトイレクリーナーもあり、塩酸特有の臭いがしません。
製法・合成法
合成方法
尿素をやや過剰の発煙硫酸と反応させ，生成する粗スルファミン酸結晶を分離し，再結晶して製品とする。
純化方法
Crystallise NH2SO3H from water at 70o (300mL per 25g), after filtering, by cooling a little and discarding the first batch of crystals (about 2.5g) before standing in an ice-salt mixture for 20minutes. The crystals are filtered off by suction, washed with a small quantity of ice cold water, then twice with cold EtOH and finally with Et2O. Dry it in air for 1hour, then store it in a desiccator over Mg(ClO4)2 [Butler et al. Ind Eng Chem (Anal Ed) 10 690 1938]. For the preparation of primary standard material see Pure Appl Chem 25 459 1969.