基本情報
- CAS
132539-07-2- 標準SMILES
CCC(=O)N(c1ccccc1)C1(C(=O)OC)CCN(CCC(=O)OC)CC1.Cl- InChIKey
WFBMIPUMYUHANP-UHFFFAOYSA-N- 分子式
- C20H29ClN2O5
- 平均分子量
- 412.9 g/mol
- 単同位体質量
- 412.1764997
概要
Remifentanil Hydrochloride is the hydrochloride salt form of remifentanil, a synthetic anilidopiperidine derivative and short-acting opiate agonist with analgesic and anesthetic properties. Remifentanil selectively binds to and activates the mu-opioid receptor, thereby producing analgesia, respiratory depression, miosis, reduced gastrointestinal motility, and euphoria.
名称と識別子
- 優先名称
- Remifentanil Hydrochloride
- IUPAC
- methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate;hydrochloride
名称と別名
REMIFENTANIL HYDROCHLORIDE132539-07-2Remifentanil HClGI 87084BGI-87084B5V444H5WICDTXSID501576141-Piperidinepropanoic acid, 4-(methoxycarbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester, monohydrochlorideCHEBI:32091RefChem:57846DTXCID6080105GI87084B
名称をさらに表示
UltivaRemifentanil hydrochloride [USAN]Remifentanil.HCl4-Carboxy-4-(N-phenylpropionamido)-1-piperidine propionic acid, dimethyl ester, monohydrochloridemethyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate;hydrochlorideUltiva (TN)Remifentanil Hydrochloride (1.0 mg/mL Acetonitrile)remifentanyl hydrochloride
データベース識別子
- CAS
132539-07-2- PubChem CID
- 60814
- DTXSID
DTXSID50157614- ChEMBL
CHEMBL1201120- UNII
- 5V444H5WIC
- EC Number
- 638-766-9
物性
構造計算による物性
- 極性表面積
- 76.2 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 6
- 回転可能結合数
- 9
- 重原子数
- 28
- 形式電荷
- 0
- 複雑度
- 522
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 1.4% (1 of 73) of reports.
Danger
H228 (11%): Flammable solid [Danger Flammable solids]
P203, P210, P240, P241, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P316, P302+P352, P304+P340, P308+P316, P316, P318, P319, P320, P321, P330, P333+P317, P361+P364, P362+P364, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 73 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Hazard Classes and CategoriesFlam. Sol. 2 (11%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Remifentanil hydrochloride
vLess-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
化学と産業
薬理情報
FDA Pharmacological Classification
REMIFENTANIL HYDROCHLORIDE
Opioid Agonist [EPC]; Full Opioid Agonists [MoA]
MeSH Pharmacological ClassificationCompounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
関連反応
0 件
現在のフィルター条件では反応記録がありません。
化合物ノート
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