Calcium Hydroxide

HCID 6093208CAS 1305-62-0

基本情報

標準SMILES
[Ca+2].[OH-].[OH-]
InChIKey
AXCZMVOFGPJBDE-UHFFFAOYSA-L
分子式
CaH2O2
平均分子量
74.09 g/mol

概要

Calcium hydroxide is an odorless white granules. Sinks in water. (USCG, 1999)

名称と識別子

優先名称
Calcium Hydroxide
IUPAC
calcium dihydroxide
英語名
calcium dihydroxide
分子式
CaH2O2
分子量
74.09

名称と別名

CALCIUM HYDROXIDE1305-62-0Slaked limeHydrated limeLime hydrateCalcium hydrateLime waterCalcium hydroxide (Ca(OH)2)HydralimeSlaked-limeLime milkCalcarea caustica
名称をさらに表示
calciumdihydroxide
INS NO.526PF5DZW74VNE-526CHEBI:31341Hydroxide, Calcium215-137-3O2 PatchRefChem:54625

データベース識別子

CAS
1305-62-0、7719-01-9
PubChem CID
6093208
ChEMBL
CHEMBL2106388
ChEBI
CHEBI:31341
UNII
PF5DZW74VN
EC Number
215-137-3、620-122-3
Nikkaji
J43.728J

物性

構造計算による物性

極性表面積
2 Ų
水素結合供与体数
2
水素結合受容体数
2
回転可能結合数
0
重原子数
3

実験および物理化学的性質

Chemical ClassesOther Classes -> Bases
Polymers · 2 件

Plastics -> Flame retardants

Plastics -> N.a.

Cosmetics · 2 件

Cosmetic ingredients (Calcium Hydroxide) -> CIR (Cosmetic Ingredient Review)

Buffering

pHpH = 12.4 (aqueous solution saturated at 25 °C)
SpringerMaterials Propertiescrystal structure
Pesticides · 2 件

Agrochemicals -> Pesticide active substances

Active substance -> EU Pesticides database: Approved

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 0.4% (28 of 6644) of reports.

Danger

H314 (22.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P332+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 6644 reports by companies from 59 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Not Classified

危険有害性情報

Regulatory Information · 5 件

Chemical: Calcium hydroxide (Ca(OH)2)

Calcium hydroxide (Ca(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Calcium hydroxide (Ca(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Reg. (EU) 2015/762

Status: No longer Valid Update: 06-07-2010 https://echa.europa.eu/registration-dossier/-/registered-dossier/1692

Calcium hydroxide: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Calcium hydroxide (Ca(OH)2): Environment tier I assessment
Fire HazardsNot combustible.
Health HazardsDust irritates eyes, nose and throat. (USCG, 1999)
Hazards SummaryA moderately caustic irritant; [ACGIH] Can cause skin burns and blisters; [ICSC] Corrosive to skin; [Quick CPC] Causes burns; [Alfa Aesar MSDS]
FDA Requirements · 3 件

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Calcium hydroxide used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Calcium hydroxide is included in antidiarrheal drug products.

安全と保護具

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures · 4 件

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention .

First Aid · 2 件

Excerpt from NIOSH Pocket Guide for Calcium hydroxide:

(General first aid procedures)

Safe StorageSeparated from strong acids.
Exposure Control and Personal Protection1.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)]
Fire Fighting Procedures · 5 件

Skin: Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

Inhalation: Fresh air, rest. Refer for medical attention.

In case of fire in the surroundings, use appropriate extinguishing media.

Eye: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Ingestion: Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention.

毒性情報

Interactions · 5 件

To determine whether cells pre-stressed by known cytotoxic or inflammatory agents are more susceptible to the deleterious effects of a calcium hydroxide formulation used in pulp capping. Adult human dermal fibroblasts were treated for 48 hr with 0.001% chlorhexidine, 0.2% ethanol, 5 ug/mL Escherichia coli lipopolysaccharide (LPS) or 0.05 mmol/L nicotine. Cells were subsequently treated with the soluble materials extracted from Dycal pellets for an additional 24 hr. Controls included cells cultured in medium only and cells exposed to Dycal only. Cytotoxicity was measured using colorimetric MTT, WST / (Water soluble Tetrazolium salt))/ and secreted lactate dehydrogenase assays. In addition, mitotic activity was evaluated using a colorimetric histone H3 phosphorylation assay. Data were statistically analysed using anova with Tukey's multiple comparison post-test and significance at P < or = 0.05. For all assays, measured values for cells treated with chlorhexidine, ethanol, LPS or nicotine plus the soluble materials extracted from Dycal pellets were significantly lower compared to control (P < 0.05) for all comparisons between experimental conditions. However, between treatments and for comparisons of treatments with Dycal, there were no differences observed for any assay. Calcium hydroxide in a formulation used in dental clinical procedures is highly cytotoxic to cultured cells, as evidenced by several cellular assays. However, other known toxic agents, including chlorhexidine, ethanol, bacterial LPS and nicotine, do not appear to function synergistically to increase the deleterious cellular effects of the calcium hydroxide in an in vitro model of cytotoxicity.

Deoxynivalenol (DON) and zearalenone (ZEN) contaminated maize was hydrothermally treated in the presence of sodium metabisulphite (SBS), methylamine and calcium hydroxide (Ca(OH)2) and included into diets for female piglets to evaluate effects on performance, organ weights, development of hyperestrogenism, serum biochemical parameters, stimulation of peripheral blood mononuclear cells and toxin residues in serum. For this purpose, both uncontaminated maize (CON) and Fusarium toxin-contaminated maize (FUS) were included into diets either untreated (-) or treated (+) according to a 2 by 2-factorial design. One-hundred female weaned piglets were assigned to one of the four treatment groups (n = 25) CON-, CON+, FUS- and FUS+ with DON/ZEN concentrations of 0.43/0.03, 0.04/0.0, 3.67/0.32 and 0.36/0.08 mg per kg diet, respectively. After a feeding period of 27 days, 20 piglets (n = 5) were slaughtered. Performance parameters such as feed intake, live weight gain and feed-to-gain ratio remained unaffected by the treatments. Uterus weights were significantly reduced in group FUS+ compared to FUS- (p = 0.028), while visceral organ weights were not influenced. Vulva width in relation to body weight was highest in group FUS- at the end of the trial, while hydrothermal treatment significantly reduced the parameter (p < 0.01). The highest toxin and toxin metabolite concentrations in serum were detected in group FUS-, whereas ingestion of diet FUS+ reduced the concentrations to the level of the control groups. Serum biochemical and haematological parameters were mainly within the given reference ranges and showed no treatment-related alterations. Stimulation of peripheral blood mononuclear cells was not affected. An effective detoxification of maize by hydrothermal treatment in the presence of SBS, methylamine and Ca(OH)2 could be demonstrated by means of serum toxin analyses. No undesired side effects of the treated-feed stuff or the chemicals themselves on the health of piglets were detected.

The objective of this study was to determine whether the addition of 5% calcium hydroxide to AH Plus sealer improves its biocompatibility in subcutaneous connective tissue of rats. Thirty female rats distributed into 3 groups of 10 animals each received subcutaneous dorsal implants of silicone tubes filled with AH Plus (Group 1), AH Plus containing 5% (wt/wt) calcium hydroxide (Group 2), or no material (Group 3: control). The animals were killed after 14 days and the subcutaneous tissue containing the tubes was removed and processed for histological analysis. Biocompatibility was assessed by evaluating the inflammatory response to the implants qualitatively and quantitatively. Data were analyzed statistically by the Wilcoxon and Kruskal-Wallis tests (alpha = 0.05). The area adjacent to the implant was characterized by nonspecific chronic inflammation and was qualitatively similar in the 3 groups. Animals implanted with AH Plus/calcium hydroxide showed significantly less intense inflammatory response when compared with the animals implanted with AH Plus alone. The addition of calcium hydroxide to AH Plus root canal sealer improved its histopathological behavior within 14 days of analysis, producing less severe inflammatory response and less cytotoxicity when implanted in the subcutaneous tissue of rats.

Biocompatibility of pulp capping materials is important for successful use in dentistry. These materials should be nontoxic and permissive for proliferation and induction of odontogenic differentiation of pulp cells. The aim of our study was to evaluate the effects of enamel matrix derivative (EMD), mineral trioxide aggregate (MTA), and calcium hydroxide-containing cement (DYCAL) on proliferation and odontogenic differentiation of human tooth germ stem cells (hTGSCs) in which cells belonging to both pulp tissue and dental follicle exist. The 96-well plates, 24-well plates, and special chamber slides were coated with biomaterials for cell proliferation, differentiation, and scanning electron microscopy analysis. Odontogenic differentiation of hTGSCs was evaluated by analyzing mRNA expression of dentin sialophosphoprotein (DSPP) by real-time polymerase chain reaction expression analysis, measurement of alkaline phosphatase activity, and visualization of calcium depositions by von Kossa staining. Our results demonstrate that EMD is the best material in terms of inducing differentiation and proliferation of hTGSCs. DYCAL was found to be toxic to hTGSCs; however, EMD-coated DYCAL showed less toxicity. EMD-coated MTA was not efficient at inducing proliferation and differentiation. Pulp capping materials come in direct contact with dental pulp cells; thus, they require comprehensive evaluation of interactions between cells and biomaterials. Therefore, we cultured hTGSCs, capable of odontogenic differentiation, on pulp capping materials directly. Our results suggest that combination of capping materials with EMD would increase the quality of capping by increasing biocompatibility of capping materials.

For more Interactions (Complete) data for CALCIUM HYDROXIDE (14 total), please visit the HSDB record page.

Target OrgansEyes, skin, respiratory system
Ecotoxicity Values · 5 件

EC50; Species: Aphanizomenon flos-aquae (Blue-Green Algae) steady state, high cell density; Conditions: freshwater, static; Concentration: 66000 ug/L for 1.5 hr; Effect: physiology, decreased nitrogen fixation

EC50; Species: Aphanizomenon flos-aquae (Blue-Green Algae) steady state, 2.5 x 10+8 cells/L; Conditions: freshwater, static; Concentration: 84000 ug/L for 22 hr; Effect: physiology, decreased nitrogen fixation

LC50; Species: Crangon septemspinosa (Bay Shrimp, Sand Shrimp); Conditions: saltwater, static, pH 6.60-12.61, salinity 28-30 ppt; Concentration: 158000 ug/L for 96 hr (95% confidence interval: 50000-500000 ug/L) /100% purity lime hydrate/

LC50; Species: Poecilia reticulata (Guppy) age 3 wk, young organism; Conditions: saltwater, renewal, 24 °C, pH >9.9 to <10.0, salinity about 2.8%, dissolved oxygen > or =70%; Concentration: 387000 ug/L for 24 hr (95% confidence interval: 218000-688000 ug/L) /97% purity/

For more Ecotoxicity Values (Complete) data for CALCIUM HYDROXIDE (9 total), please visit the HSDB record page.

Environmental Fate · 2 件

Aquatic Fate: Aquatic toxicity is the function of an alkalinity effect. Addition of lime to soft water lakes has increased biological activity, possibly by providing a carbon dioxide reservoir.

Calcium hydroxide does not degrade by photooxidation; it is neutralized by absorption of atmospheric carbon dioxide.

Adverse EffectsDermatotoxin - Skin burns.
Exposure Routes · 2 件

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

inhalation, ingestion, skin and/or eye contact

法規制情報

FDA Requirements · 3 件

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Calcium hydroxide used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: Calcium hydroxide is included in antidiarrheal drug products.

FIFRA Requirements · 2 件

Residues of calcium hydroxide are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: solid diluent, carrier.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Calcium hydroxide is found on List D. Case No: 4066; Pesticide type: Fungicide, Herbicide, Antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): Calcium hydroxide; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

用途と製造

Uses · 6 件

CIR ingredient: Calcium Hydroxide

Used in mortar, plaster, cement, lubricants, drilling fluids, paper pulp, and water treatment; also used to dehair hides; [ACGIH] Used in pesticides, fireproofing coatings, water-based paints, SBR rubber vulcanization, binding and paving materials, soil treatments, brewing manufacture, dental cements, petrochemicals, as chemical intermediate, buffering agent for metals, pearls, and celluloid, disinfectant, food additive, for ammonia recovery in gas manufacture, purification of sugar juices, to preserve eggs and apples during storage, in cattle feeds, and veterinary medicine; [HSDB] Used as both an inert and active ingredient (microbiocide/microbiostat) in pesticide products; [EPA REDs] Used as a nutritional supplement, pH control agent, firming agent, and processing aid for foods; [FDA]

Petroleum Production and Refining [Category: Industry]

For calcium hydroxide (USEPA/OPP Pesticide Code: 075601) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

In mortar, plaster, cement and other binding and paving materials; in lubricants, drilling fluid, pesticides, fireproofing coatings, water paint; as egg preservative; manufacture of paper pulp; in SBR rubber vulcanization; in water treatment; as absorbant for carbon dioxide; dehairing hides.

Chem int in chlorohydrin process for propylene oxide /former use/; chem int for calcium hypochlorite, bleaching powder, and the fungicide, lime-sulfur spray; flux in iron and steel mfr; soil treatment for acidic soils; water softening agent; stabilization of soils for road base; component of sand-lime bricks and blocks; component of masonary mortar; water correcting agent in brewing mfr; component of dental cement; buffering agent for metals, pearls and celluloid.

ImpuritiesCalcium carbonate, magnesium salts, iron.
U.S. Imports · 2 件

(1972) 3.4X10+11 G

(1975) 4.05X10+10 G

U.S. Production · 5 件

2023: 10,000,000,000 - <15,000,000,000 lb

(1975) 2.13X10+12 G

Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#2426]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Calcium hydroxide. Aggregated National Production Volume: 1 billion pounds and greater.

Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Calcium hydroxide. National Production Volume: 17,976,380,341 lb/yr.

Consumer UsesChemical reaction regulator
Industry UsesOther

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