ジブチルジチオカルバミン酸ニッケル(II)

Dry Powder

Dark green solid; [Hawley] Flakes; [MSDSonline]

This chemical does not meet GHS hazard criteria for 36.4% (4 of 11) of reports.

Warning

H319 (54.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 11 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Not Classified

Chemical: Nickel, bis(dibutylcarbamodithioato-S,S')-, (SP-4-1)-

Nickel, bis(N,N-dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (SP-4-1)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Nickel, bis(N,N-dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (SP-4-1)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Nickel bis(dibutyldithiocarbamate) (EC: 237-696-2)

Restricted substance: Nickel bis(dibutyldithiocarbamate)

Nickel, bis(dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (SP-4-1)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Nickel, bis(dibutyldithiocarbamato)- is included on this list.

NIOSH considers nickel metal and other compounds (as Ni) to be a potential occupational carcinogen. /Nickel metal and other compounds (as Ni)/

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Nickel metal and other compounds (as Ni)/

Recommended Exposure Limit: 10 Hr TWA 0.015 mg/cu m. /Nickel metal and other compounds (as Ni)/

Eye Irrit. 2 (54.5%)

Carcinogenicity - Category 1A

(CA) CALIFORNIA 100 ug/L /Nickel/

(CT) CONNECTICUT 100 ug/l /Nickel/

(DE) DELAWARE 100 ug/l /Nickel/

(FL) FLORIDA 100 ug/L /Nickel/

(WI) WISCONSIN 100 ug/L /Nickel/

(AZ) ARIZONA 150 ug/l /Nickel/

(MA) MASSACHUSETTS 100 ug/l /Nickel/

(ME) MAINE 140 ug/l /Nickel/

(MN) MINNESOTA 100 ug/l /Nickel/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

8 hr Time Weighted Avg (TWA) 0.2 mg/cu m (inhalable fraction). /Nickel, insoluble compounds, as Ni/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Nickel, insoluble compounds, as Ni/

A1: Confirmed human carcinogen. /Nickel, insoluble compounds, as Ni/

The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41)

Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, A40)

A1: Confirmed human carcinogen. /Nickel, insoluble compounds, as Ni/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of nickel sulfate, and of the combinations of nickel sulfides and oxides encountered in the nickel refining industry. There is inadequate evidence in humans for the carcinogenicity of metallic nickel and nickel alloys. There is sufficient evidence in experimental animals for the carcinogenicity of metallic nickel, nickel monoxides, nickel hydroxides and crystalline nickel sulfides. There is limited evidence in experimental animals for the carcinogenicity of nickel alloys, nickelocene, nickel carbonyl, nickel salts, nickel arsenides, nickel antimonide, nickel selenides and nickel telluride. There is inadequate evidence in experimental animals for the carcinogenicity of nickel trioxide, amorphous nickel sulfide and nickel titanate. The Working Group made the overall evaluation on nickel compounds as a group on the basis of the combined results of epidemiological studies, carcinogenicity studies in experimental animals, and several types of other relevant data, supported by the underlying concept that nickel compounds can generate nickel ions at critical sites in their target cells. Overall evaluation: Nickel compounds are carcinogenic to humans (Group 1). Metallic nickel is possibly carcinogenic to humans (Group 2B). /Nickel compounds/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 t0 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Nickel and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Consider drug therapy for pulmonary edema ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nickel and related compounds/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Nickel, bis(dibutyldithiocarbamato)- is included on this list.

(CA) CALIFORNIA 100 ug/L /Nickel/

(CT) CONNECTICUT 100 ug/l /Nickel/

(DE) DELAWARE 100 ug/l /Nickel/

(FL) FLORIDA 100 ug/L /Nickel/

(WI) WISCONSIN 100 ug/L /Nickel/

(AZ) ARIZONA 150 ug/l /Nickel/

(MA) MASSACHUSETTS 100 ug/l /Nickel/

(ME) MAINE 140 ug/l /Nickel/

(MN) MINNESOTA 100 ug/l /Nickel/

Nickel is absorbed mainly through the lungs and gastrointestinal tract. Once in the body it enters the bloodstream, where it binds to albumin, L-histidine, and _2-macroglobulin. Nickel tends to accumulate in the lungs, thyroid, kidney, heart, and liver. Absorbed nickel is excreted in the urine, wherease unabsorbed nickel is excreted in the faeces. (L41)

Used as accelerator for rubber vulcanization and an antioxidant for synthetic rubbers; [HSDB]

ACCELERATOR FOR RUBBER VULCANIZATION

Antioxidant for synthetic rubbers

2022: 42,732 lb

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

"NBC" /IS DU PONT DE NEMOURS, EI & CO/ DESIGNATION FOR NICKEL DIBUTYLDITHIOCARBAMATE.

RYLEX NBC

VANGUARD N

Rubber Product Manufacturing

Nickel, bis(N,N-dibutylcarbamodithioato-.kappa.S,.kappa.S')-, (SP-4-1)-: ACTIVE