CAS 156-51-4 Phenelzine Sulfate (HCID 61100)

名称と識別子

優先名称: Phenelzine Sulfate
IUPAC: 2-phenylethylhydrazine;sulfuric acid
現地名: フェネチルヒドラジン·硫酸塩
英語名: Phenelzine Sulfate
分子式: C8H14N2O4S
分子量: 234.27

名称と別名

Phenelzine sulfate156-51-4Phenelzine sulphatePhenelzine acid sulfateHydrazine, (2-phenylethyl)-, sulfate (1:1)Phenethylhydrazine sulfate (1:1)2-Phenylethylhydrazine sulphateNSC-1709572-Phenylethylhydrazine hydrogen sulphatePhenelzine sulfate (USP)Phenelzine sulfate [USP]2681D7P965

名称をさらに表示

フェネルジン硫酸塩フェネチルヒドラジン·硫酸塩ナルジルフェネルジンスルフェイト硫酸フェネルジンフェネルジン硫酸塩フェネチルヒドラジン・硫酸塩Phenelzine Sulfate (1517006)wl7p1531ep-411alazinkalganS-1544alacine

NSC170957Sulfate, PhenelzineRefChem:55843205-856-0AlazinePHENELZINE SULFATE SALTPhenethylhydrazine sulfateEstinerval

データベース識別子

CAS: 156-51-4
PubChem CID: 61100
DTXSID: DTXSID3021144
ChEMBL: CHEMBL1200895
ChEBI: CHEBI:8061
UNII: 2681D7P965
EC Number: 205-856-0

物性

構造計算による物性

極性表面積: 121 Å²
水素結合供与体数: 4
水素結合受容体数: 6
回転可能結合数: 3
重原子数: 15
形式電荷: 0
複雑度: 159

物理化学的性質

融点: 166.5 · 166.5-167.5 °C
貯蔵温度: 2 · 2-8°C
溶解性: 水に溶けやすい。エタノール (96%) およびエーテルに実質的に不溶。
外見: A solid
色: White to off-white
由来生物: synthetic
水溶解度: 50 mg/mL, · water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow
Merck: 13 · 13,7300
主な用途: 医薬品（低分子化合物）
InChI: InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChIKey: RXBKMJIPNDOHFR-UHFFFAOYSA-N
SMILES: C1(CCNN)C=CC=CC=1.S(=O)(=O)(O)O
CAS データベース: 156 · 156-51-4

化学的性質

化学的特性A white powder or pearly platelets.

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Other Safety InformationIMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Human health tier I assessment；IMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 3 (100%)

毒性情報

Carcinogen Classification · 5 件

Phenelzine sulfate

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 24: (1980) Some Pharmaceutical Drugs；Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

1987

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Phenelzine sulfate

vLess-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

安全データ

wgk: 3
rtecs: MV8750000
ridadr: UN 2811 6.1/PG 3
毒性: LD50 orally in mice: 156 mg/kg (Gylys)
hs_code: 2928002500
risk_code: 22
hazard_code: Xn
hazard_class: 6.1(b)
packing_group: III
Hazard Classifications: Acute Tox. 3 Oral
ストレージクラス: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

PHENELZINE SULFATE

Monoamine Oxidase Inhibitors [MoA]; Monoamine Oxidase Inhibitor [EPC]

MeSH Pharmacological Classification · 2 件

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

応用分野 · 2 件

使用Phenelzine Sulfate is a hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidep ressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.

一般的な説明Phenelzine sulfate, 2-(phenylethyl)hydrazine sulfate(Nardil), is an effective antidepressant agent. A mechanismbasedinactivator, it irreversibly inactivates the enzyme orits cofactor, presumably after oxidation to the diazine,which can then break up into molecular nitrogen, a hydrogen atom, and a phenethyl free radical. The latter would bethe active species in irreversible inhibition.