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メチルジクロロアルシン

As-Methylarsonous dichloride

HCID 61142
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基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
593-89-5
標準SMILES
C[As](Cl)Cl
InChIKey
VXRMBBLRHSRVDK-UHFFFAOYSA-N
分子式
CH3AsCl2
平均分子量
160.86 g/mol
単同位体質量
159.882775

概要

Methyldichloroarsine appears as a chemical warfare blister agent. Very toxic by inhalation. A colorless liquid with an agreeable odor. Denser than water. Painful burns on contact.

名称と識別子

優先名称
As-Methylarsonous dichloride
IUPAC
dichloro(methyl)arsane
現地名
メチルジクロロアルシン
英語名
Methyldichloroarsine.
分子式
CH3AsCl2
分子量
160.86

名称と別名

METHYLDICHLOROARSINEMethyldichlorarsineDichloromethylarsineMethylarsonous dichloridedichloro(methyl)arsaneMethylarsine dichloride593-89-5Arsonous dichloride, As-methyl-DTXSID0060480RefChem:818562As-Methylarsonous dichlorideDTXCID6042604
名称をさらに表示
メチル亜アルソン酸ジクロリド(ジクロロメチル)アルシンメチルジクロロアルシンジクロロメチルアルシンｼﾞｸﾛﾛ(ﾒﾁﾙ)ｱﾙｼﾝTL-294methyldichloroarsaneMethyldichloroarsine.METHYL-ARSINEDICHLORIDEMethylarsonous aciddichloride
Arsonous dichloride, methyl-Arsine, dichloromethyl-TL 294NA1556Methyl dichloroarsineBRN 1731061MethyldichlorarsinSCHEMBL898232

データベース識別子

CAS
593-89-5
PubChem CID
61142
DTXSID
DTXSID0060480
EC Number
695-189-5
Nikkaji
J35.217I

物性

構造計算による物性

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
0
回転可能結合数
0
重原子数
4
形式電荷
0
複雑度
13.5

実験および物理化学的性質

Chemical Classes · 2 件

Toxic Gases & Vapors -> Chemical Weapons

Reactive agents - 1st degree

Density1.84 @ 20°C
Melting Point-59 °C
Vapor Pressure10 [mm Hg] @24.3 °C
Physical Description · 2 件

Methyldichloroarsine appears as a chemical warfare blister agent. Very toxic by inhalation. A colorless liquid with an agreeable odor. Denser than water. Painful burns on contact.

Ccolorless liquid with an agreeable odor; [CAMEO]

物理化学的性質

融点
-50.4 °C · -50.4°C
沸点
129.8 °C · 129.8°C (estimate)
比重(密度)
1.84 · 1.8400
屈折率
1.566 · 1.5660
外見
液体
Henry's Law Constant
5.1 · 5.1×10-3 mol/(m3Pa) at 25℃, Ebert et al. (2023)
CAS データベース
593 · 593-89-5
EPAの化学物質情報
Arsonous dichloride, As-methyl- (593-89-5)

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 4 件

Danger

H300+H310+H330 (100%): Fatal if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

危険有害性情報

Hazards IdentificationToxic/poison by inhalation (TIH/PIH)
Regulatory Information · 2 件

Restricted substance: Arsine, dichloromethyl-

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelPoison Inhalation Hazard
Fire Hazards · 2 件

For information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

· Combustible material: may burn but does not ignite readily.

Health Hazards · 2 件

For information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.

Hazards SummaryContact with material causes severe burns; Highly toxic by inhalation, ingestion, or skin absorption; [CAMEO] High dose exposure may cause abdominal pain, convulsions, and death; [NJ-HSFS]
DOT ID and Guide1556 152

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)

用途と製造

Uses · 2 件

Used as a military poison; [NJ-HSFS]

Methyldichloroarsine belongs to the group of chemical warfare agents known as blister agents or vesicants. Due to its toxicity, it is nowadays considered obsolete. (L366)

General Manufacturing InformationArsonous dichloride, As-methyl-: ACTIVE

応用分野

使用Military poison, intermediate.

一般的な説明A colorless liquid with an agreeable odor. Denser than water. Very toxic by inhalation. Painful burns on contact.

サプライヤー

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関連反応

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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

化学的性質

化学的特性A colorless, mobile liquid; agreeableodor. Decomposed by water.

Reactive GroupAcyl Halides, Sulfonyl Halides, and Chloroformates
Reactivity AlertsStrong Reducing Agent
Reactivity Profile · 1 件

METHYLDICHLOROARSINE is a reducing agent. Reacts rapidly and dangerously with oxygen and with other oxidizing agents, even weak ones. Can ignite on contact with alcohols. Incompatible with acids, alcohols, amines, and aldehydes. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. In one instance, reaction with chlorine rapidly produced gaseous chloromethane, which led to an over pressurization failure [J. Chem. Soc., Dalton Trans., 1976, 1479].

DOT Hazard Classification · 5 件

Methyldichloroarsine

NA1556

Div 6.1 Poisonous materials (49 eCFR § 173.132)

PG I: the degree of danger presented by the material is great

Symbol D: The proper shipping name which is appropriate for describing material for domestic transportation

Air and Water ReactionsDecomposes slowly in water to form a corrosive solution of HCl.

安全と保護具

Fire FightingFor information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Accidental Release Measures · 2 件

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 2 件

For information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

General First Aid:

Exposure Control and Personal Protection · 2 件

· Wear positive pressure self-contained breathing apparatus (SCBA).

TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].

Nonfire Spill ResponseFor information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Isolation and Evacuation · 4 件

For initial isolation and protective action distances for chemical warfare blister agents see the Chemical Warfare Agents table in the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)

Immediate precautionary measure

Small spill:

Small spill:

Minimum Risk LevelAcute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
Protective Action Criteria (PAC) · 3 件

0.0048 [mg/m3]

0.053 [mg/m3]

0.16 [mg/m3]

Personal Protective Equipment (PPE)For information on chemical warfare blister agents see the ERG Criminal or Terrorist Use of CBR Agents. (ERG, 2024)
Emergency Response Planning GuidelinesSmall Fire
AEGLs NotesNOTE THAT VALUES ARE IN mg/m3, NOT ppm. NR = Not recommended due to insufficient data
AEGLs Table · 6 件

AEGL 1: Notable discomfort, irritation, or certain asymptomatic non-sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure (Unit: mg/m3)

NR

NR

NR

NR

NR

毒性情報

Treatment · 1 件

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

Health EffectsArsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
Adverse EffectsDermatotoxin - Skin burns.
Exposure RoutesOral (L2) ; inhalation (L2) ; dermal (L2)
Toxicity Summary · 1 件

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and SymptomsExposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of
Carcinogen Classification3, not classifiable as to its carcinogenicity to humans. (L135)

安全データ

tsca
TSCA listed
ridadr
2845
hazard_class
4.2
packing_group
I