1,2-ビス(クロロメトキシ)エタン

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

1,2-Bis(chloromethoxy)ethane

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 15: (1977) Some Fumigants, the Herbicides 2,4-D and 2,4,5-T, Chlorinated Dibenzodioxins and Miscellaneous Industrial Chemicals

1999

1998

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Fifty 6-8 wk old female ICR/Ha Swiss mice were administered 1 mg 1,2-bis(chloromethoxy)ethane in 0.1 ml cyclohexane on the dorsal skin thrice weekly for up to 502 days, at which time more than half the animals were still alive. Four mice developed skin papillomas, the first of which appeared after 320 days, and 4 animals had local squamous-cell carcinomas (p<0.05). In 50 control mice treated with cyclohexane only, the median survival time was >504 days; no tumors occurred at the site of administration.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Fifty 6-8 wk old female ICR/Ha Swiss mice were given weekly sc injections of 0.3 mg 1,2-bis(chloromethoxy)ethane in 0.05 ml tricaprylin. The test lasted 569 days, and the median survival time of treated mice was 362 days. Nine mice had local sarcomas (p<0.01). In 50 control animals treated with tricaprylin alone, the median survival time was 436 days; no local malignant tumors occurred.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Thirty 6-8 wk old female ICR/Ha Swiss mice were given weekly ip injections of 0.3 mg 1,2-bis(chloromethoxy)ethane in 0.05 ml tricaprylin. The test lasted 546 days, and the median survival time of treated mice was 481 days. Two mice developed undifferentiated malignant tumors at the injection site, and 2 had local sarcomas (p<0.05). In 30 controls treated with tricaprylin alone, the median survival time was 513 days; no local malignant tumors occurred.

A research chemical that has been tested for use in textiles (wrinkle-resistance and dyeing), rubber (stabilizer),epoxy resins (curing agent), lithographic plates (light-sensitive polymers), and ion exchange resins; [HSDB]

Plastic Composites Manufacturing [Category: Industry]

Although 1,2-bis(chloromethoxy)ethane does not appear to have been used commercially, it has been investigated for potential commercial use on cellulosic textiles for imparting crease resistance; improving wet strength and facilitating dyeing; as a stabilizer for vulcanized rubbers; as a curing agent for epoxy resins; in the preparation of light-sensitive polymers for lithographic plates; and in the synthesis of ion-exchange resins.