ビス過塩素酸鉛(II)

Metals -> Lead Compounds, Inorganic

Carcinogens

Lead perchlorate appears as a white crystalline solid. A dangerous fire risk when in contact with reducing materials. Very toxic by ingestion. Used to make paints and in electric storage batteries.

White solid; [CAMEO]

Danger

H272 (50%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P203, P210, P220, P260, P261, P264, P270, P271, P273, P280, P301+P317, P304+P340, P317, P318, P319, P330, P370+P378, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Restricted substance: Lead diperchlorate

Perchloric acid, lead(2+) salt: HSNO Approval: HSR001362 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

· These substances will accelerate burning when involved in a fire.

· These substances will accelerate burning when involved in a fire.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

· Toxic by ingestion.

· Toxic by ingestion.

1470 141

3408 141

LEAD PERCHLORATE is a strong oxidizing agent. Can react with reducing agents to generate heat and products that may be gaseous (causing pressurization in closed containers). The products may themselves be capable of further reactions (such as combustion in the air). Redox reactions can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Consequently explosive mixtures with reducing agents often persist unchanged for long periods. Such systems are typically mixtures of solids, but may involve any combination of physical states. Can react violently with active metals, cyanides, esters, and thiocyanates. May cause the acceleration of the burning of combustible materials. Prolonged exposure to heat of flames may result in an explosion. A flask of anhydrous lead perchlorate dissolved in methyl alcohol exploded when it was disturbed [J. Am. Chem. Soc. 52:2391. 1930].

Lead perchlorate, solid or solution

Marine pollutant

Lead perchlorate, solid

UN1470

Div 5.1 Oxidizer (49 eCFR § 173.127)

Div 5.1 Oxidizer (49 eCFR § 173.127)

Ox. Sol. 2 (50%)

Carcinogens

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Biological Exposure Indices (BEI) [ACGIH] - Lead in blood = 200 ug/L (20 ug/100 ml); sampling time not critical; [ACGIH]

Excerpt from ERG Guide 141 [Oxidizers - Toxic]:

Immediate precautionary measure

Immediate precautionary measure

Small Fire

Small Fire

Lead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. (L21)

Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (T4, A20, A22, L136)

Symptions of chronic lead poisoning include reduced cognitive abilities, nausea, abdominal pain, irritability, insomnia, metal taste in the mouth, excess lethargy or hyperactivity, chest pain, headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal problems, such as constipation, diarrhea, vomiting, poor appetite, weight loss, which are common in acute poisoning. (A2, L21)

Lead is absorbed following inhalation, oral, and dermal exposure. It is then distributed mainly to the bones and red blood cells. In the blood lead may be found bound to serum albumin or the metal-binding protein metallothionein. Organic lead is metabolized by cytochrome P-450 enzymes, whereas inorganic lead forms complexes with delta-aminolevulinic acid dehydratase. Lead is excreted mainly in the urine and faeces. (L136)

Used to make paints and storage batteries; [CAMEO]

Battery Manufacturing [Category: Industry]