4-デセナール

soluble in alcohol and most fixed oils; insoluble in water

(in ethanol)

This chemical does not meet GHS hazard criteria for 100% (138 of 138) of all reports.

Not Classified

Aggregated GHS information provided per 138 reports by companies from 1 notifications to the ECHA C&L Inventory.

Chemical: 4-Decenal

4-Decenal: Does not have an individual approval but may be used under an appropriate group standard

Uremic toxins such as 4-Decenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869).

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