2-(2,4-ジクロロフェノキシ)プロパン酸2-ブトキシエチル

LC50; Species: Colinus virginianus (Northern Bobwhite Quail) age 14 days; diet >10000 ppm for 8 days /100% purity/

LC50; Species: Colinus virginianus (Northern Bobwhite Quail) diet >10000 ppm for 8 days /59.1% purity/

LD50; Species: Colinus virginianus (Northern Bobwhite Quail) age 18 weeks; oral via capsule 1517 mg/kg (95% confidence interval: 810-2250 mg/kg) /95.3% purity/

LC50; Species: Anas platyrhynchos (Mallard Duck) diet >10000 ppm for 8 days /59.1% purity/

For more Ecotoxicity Values (Complete) data for Dichlorprop-butotyl (16 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 970(SRC), determined from a structure estimation method(2), indicates that dichlorprop-butotyl is expected to have moderate mobility in soil(SRC). Volatilization of dichlorprop-butotyl from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Dichlorprop-butotyl is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.0X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Biodegradation data in soil were not available(SRC, 2018).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 970(SRC), determined from a structure estimation method(2), indicates that dichlorprop-butotyl is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 470 and 3400 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 450(SRC), from an estimated log Kow of 4.52(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegradation data in water were not available(SRC, 2018).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dichlorprop-butotyl, which has an estimated vapor pressure of 4.0X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dichlorprop-butotyl is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hrs(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase dichlorprop-butotyl may be removed from the air by wet and dry deposition(SRC). Dichlorprop-butotyl contains chromophores that absorb at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dichlorprop-butotyl can be estimated to be 970(SRC). According to a classification scheme(2), this estimated Koc value suggests that dichlorprop-butotyl is expected to have low mobility in soil(SRC).

An estimated BCF of 450 was calculated in fish for dichlorprop-butotyl(SRC), using an estimated log Kow of 4.52(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for dichlorprop-butotyl is estimated as 1.4X10-7 atm-cu m/mole(SRC) developed using a fragment constant estimation method(1). This Henry's Law constant indicates that dichlorprop-butotyl is expected to be essentially nonvolatile from water and moist soil surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 470 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 3400 days(SRC). Dichlorprop-butotyl is not) expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 4.0X10-6 mm Hg(SRC), determined from a fragment constant method(1).

The rate constant for the vapor-phase reaction of dichlorprop-butotyl with photochemically-produced hydroxyl radicals has been estimated as 1.4X10-7 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 2.6 L/mole-sec(SRC) was estimated using a structure estimation method(1); this corresponds to half-lives of 300 and 31 days at pH values of 7 and 8, respectively(1). Dichlorprop-butotyl contains chromophores that absorb at wavelengths >290 nm(2) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

Water quality data compiled from the Retrieval (STORET) Data Warehouse and the USGS National Water Information System (NWIS) reports surface water and ground water monitoring data for various chemicals but did not include dichlorprop-butotyl as of 2018(1).

Dichlorprop-butotyl's production may result in its release to the environment through various waste streams; its former use as an herbicide resulted in its direct release to the environment. If released to air, an estimated vapor pressure of 4.0X10-6 mm Hg at 25 °C indicates dichlorprop-butotyl will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase dichlorprop-butotyl will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 14 hrs. Particulate-phase dichlorprop-butotyl will be removed from the atmosphere by wet and dry deposition. Dichlorprop-butotyl contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If released to soil, dichlorprop-butotyl is expected to have moderate mobility based upon an estimated Koc of 970. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.4X10-7 atm-cu m/mole. Dichlorprop-butotyl is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data in soil or water were not available. If released into water, dichlorprop-butotyl is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 470 and 3400 days, respectively. An estimated BCF of 450 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is expected to be an important environmental fate process with second order half-lives of 300 and 31 days at pH 7 and 8, respectively. Occupational exposure and general population exposure should be low or non-existent since dichlorprop-butotyl is no longer produced or used in the US. (SRC)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Chlorophenoxy herbicides and related compounds/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Monitor body temperature and treat if necessary. /Chlorophenoxy herbicides and related compounds/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's /SRP: "To keep open", minimal flow rate/. Titrate to maintain adequate urine flow. For hypotension with signs of hypovolemia, administer fluid cautiosly. Consider vasopressors if patient is hypotensive with a normal fluid volume ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Chlorophenoxy herbicides and related compounds/

1. Decontaminate skin and hair by bathing with soap and water and shampooing. Individuals with chronic skin disease or known sensitivity to these herbicides should either avoid using them or take strict precautions to avoid contact (respirator, gloves, etc). /Chlorophenoxy herbicides/

For more Antidote and Emergency Treatment (Complete) data for Dichlorprop-butotyl (12 total), please visit the HSDB record page.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Butoxyethyl 2-(2,4-dichlorophenoxy)propionate is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0294; Pesticide type: herbicide; Registration Standard Date: 09/01/88; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): Butoxyethyl 2-(2,4-dichlorophenoxy)propionate; Data Call-in (DCI) Date(s): 07/26/94, 03/03/95, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.