L-(-)-Ornithine｜化工社

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HCID 6262作成日：2026年10月27日

L-(-)-Ornithine

polyornithine · L-Ornithine, homopolymer

https://huagongshe.com/ja/chemical/6262

L-(-)-Ornithine の分子構造式

識別子と物理属性

CAS No.	25104-12-5
分子式	C5H12N2O2
平均分子量	132.16 g/mol
単同位体質量	132.08987762 g/mol
SMILES	NCCC[C@H](N)C(=O)O
InChIKey	AHLPHDHHMVZTML-BYPYZUCNSA-N
PubChem CID	6262
ChEMBL	CHEMBL446143
ChEBI	CHEBI:15729
EC No.	200-731-7
DTXSID	DTXSID00883219

化学・物理的性質

XLogP	-4.4
極性表面積	89.3
水素結合供与体数	3
水素結合受容体数	4
回転可能結合数	4
重原子数	9
形式電荷	0
複雑度	95
物質分類	Biological Agents -> Amino Acids and Derivatives
医薬品	Pharmaceuticals -> Listed in ZINC15
化粧品	Skin conditioning
SpringerMaterials Properties	15N nuclear magnetic resonance spectrum
LogP（分配係数）	-4.22
溶解度	Appreciable620 mg/mL
融点	140 °C
Physical Description	Colorless solid[Merck Index]
Dissociation Constants	1.94 (at 25 °C)
Collision Cross Section	127.7 Å² [M+H]+ [CCS Type: DTMethod: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]129.79 Å² [M+H]+ [CCS Type: DTMethod: stepped-field]127.81 Å² [M+Na]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]121 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine]

安全性と法規制

GHS 分類	This chemical does not meet GHS hazard criteria for 100% (6 of 6) of all reports.Not ClassifiedAggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory.
規制情報	Chemical: L-OrnithineStatus: Active Update: 13-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23820L-Ornithine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
その他の安全情報	IMAP assessments - L-Ornithine: Environment tier I assessment
Hazard Classes and Categories	Not Classified
健康影響	Chronically high levels of ornithine are associated with at least 9 inborn errors of metabolism including: Cystathionine Beta-Synthase Deficiency, Hyperornithinemia with gyrate atrophy, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperprolinemia Type II, Lysinuric Protein Intolerance, Ornithine Aminotransferase Deficiency, Ornithine Transcarbamylase Deficiency and Prolinemia Type II.
暴露経路	Absorbed from the small intestine via a sodium-dependent active transport process
毒性の概要	L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).
Carcinogen Classification	No indication of carcinogenicity to humans (not listed by IARC).
Toxicity Data	Oral, rat LD<sub>50</sub> = 10000 mg/kg