[3-(トリメトキシシリル)プロピル]ジメチル(オクタデシル)アミニウム·クロリド

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

LC50; Species: Colinus virginianus (Northern Bobwhite Quail) age 14 days; diet >5620 ppm for 8 days

LC50; Species: Anas platyrhynchos (Mallard Duck) age 14 days; diet >5620 ppm for 8 days

LD50; Species: Anas platyrhynchos (Mallard Duck) age 24 weeks; oral via capsule >1590 mg/kg

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: 720 ug/L for 48 hr (95% confidence interval: 600-850 ug/L); Effect: intoxication, immobilization /42% purity/

For more Ecotoxicity Values (Complete) data for 3-(Trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: As a cationic quaternary ammonium salt, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will completely ionize in water at environmental pHs. The silyl portion of the molecule will become part of the soil and sediment matrices because of their high silica content(1). In water, it hydrolyzes rapidly and the hydrolytic cationic portion of the molecule (quaternary ammonium) will sorb readily to soil and sediment due to opposite electrical charges(1). Volatilization of 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride from moist soil surfaces is not expected to be an important fate process(SRC) given the compound will exist in ionic form and it hydrolyzes readily(1). 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 5.8X10-14 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Biodegradation data in soil were not available(SRC, 2016).

AQUATIC FATE: As a cationic quaternary ammonium salt, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will completely ionize in an aqueous solution(1). 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride hydrolyzes rapidly in water with a half-life of <1 hour(1). Volatilization of 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride from water surfaces is not expected to be an important fate process(SRC) given the compound will exist in ionic form and it hydrolyzes readily(1). In water, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride hydrolyzes rapidly(1) which will attenuate any bioconcentration of the parent compound. The trimethoxysilyl quats are not expected to contaminate surface or ground water due to rapid degradation by hydrolysis(2).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride, which has an estimated vapor pressure of 5.8X10-14 mm Hg at 25 °C((SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride may be removed from the air by wet and dry deposition(SRC). 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: 3-(Trimethoxysilyl)propyldimethyloctadecylammonium (Trimethoxysilyl quat) is registered for pesticide use in the USA. Trimethoxysilyl quat containing products are currently used as a material preservative treatment for materials such as those used in human clothing and bedding, carpets and upholstery. The trimethoxysilyl quats are used as surface treatments in household areas and bathroom areas. These products are also used in the manufacturing of paints, coatings, and in concrete. HUMAN EXPOSURE AND TOXICITY: There are no data avalable. ANIMAL STUDIES: Severe dermal irritation in rabbit, and severe ocular toxicity in rat. Oral administration as high as 1000 mg/kg/day did not produce teratogenicity or other indications of developmental toxicity in the rat conceptus. Trimethoxysilyl Quats were not mutagenic in the In-vitro Reverse Mutation Assay, or In-vitro Forward Mutation Assay in Salmonella, and E-coli. It did not induce structural chromosome aberrations in Chinese hamster cells, and it was negative in mouse micronucleus test.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of December 17, 2015: http://actor.epa.gov/dashboard/]

As a cationic quaternary ammonium salt, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will completely ionize in water at environmental pH. In water, it hydrolyzes rapidly and the hydrolytic cationic portion of the molecule (quaternary ammonium) will sorb readily to soil and sediment due to opposite electrical charges. The silyl portion of the molecule will become part of the soil and sediment matrices because of their high silica content(1).

3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride's production and use as a material preservative treatment for materials such as human clothing, bedding, carpets and upholstery(1) may result in its release to the environment through various waste streams; its use as a bacteriastatic, algaestatic and fungistatic compound(1) will result in its direct release to the environment(SRC).

As a cationic quaternary ammonium salt, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will completely ionize in an aqueous solution(1). Since ions do not volatilize, the compound is expected to be essentially nonvolatile from water surfaces and moist soil(SRC). In addition, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride hydrolyzes rapidly in water(1) which would attenuate the importance of volatilization from water if it was occurring(SRC). 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 5.8X10-14 mm Hg(SRC), determined from a fragment constant method(2).

/LABORATORY ANIMALS: Acute Exposure/ /Dermal Irritation/ Rabbit: Severe dermal toxicity /Trimethoxysilyl Quats/

/LABORATORY ANIMALS: Acute Exposure/ /Eye Irritation/ Rat: Severe Ocular Toxicity /Trimethoxysilyl Quats/

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ The developmental toxicity of an antimicrobial organosilicon quaternary ammonium chloride (Quaternary Silsesquioxane) was evaluated in rats. Groups of 25 pregnant CD rats were administered 100, 300, or 1000 mg/kg/day of test material by gavage as a single daily dose on Days 6 through 15 of gestation at a volume of 10 mL/kg. The control group received only corn oil as the vehicle. Cesarean examinations were performed on all females on Gestation Day 20 followed by evaluation of the fetuses for teratogenicity. Maternal effects included a slight but statistically significant increase in relative liver weights at the 1000 mg/kg/day dose level. Using these hepatic changes as an adverse effect, the maternal no observable adverse effect level for this study was identified at 300 mg/kg/day. The number of corpora lutea, implantation sites, viable fetuses, and early and late resorptions, the fetal body weights, the crown-rump length, and the gravid uterine and corrected body weights were not affected by the administration of Quat-Silsesquioxane. The occurrence of external and internal soft tissue malformations and variations and the incidences of skeletal malformations and variations in the treated groups were not significantly different from those in the control group. These results demonstrated that oral administration of Quat-Silsesquioxane as high as 1000 mg/kg/day did not produce teratogenicity or other indications of developmental toxicity in the rat conceptus.

/GENOTOXICITY/ /Chromosome Aberration/ Chinese hamster cells: No association with the induction of structural chromosome aberrations /Trimethoxysilyl Quats/

For more Non-Human Toxicity Excerpts (Complete) data for 3-(Trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride (10 total), please visit the HSDB record page.

3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride hydrolyzes rapidly in water(1). In water, the trimethoxysilyl quaternary ammonium compounds (QACs) degrade quickly to the quaternary amine portion (active and soluble) and the other silyl portion (inactive and insoluble) with half-lives <1 hour(1). On contact with water, the methoxy groups attached to the silicon atom in the 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride molecule react in a stepwise manner to form silanols(2). The silanol moieties are very reactive and can react through a condensation type reaction to form a variety of polymers(2). 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride does not contain chromophores that absorb at wavelengths >290 nm(1) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

According to the 2012 TSCA Inventory Update Reporting data, 2 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride in the United States may be as low as <10 workers and as high as <10 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

Occupational exposure to 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride may occur through inhalation (e.g. spray application) and dermal contact with this compound at workplaces where 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride is produced or used(1). Use data indicate that the general population may be exposed to 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride via dermal contact with consumer products containing 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride(SRC).

3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride's production and use as a material preservative treatment for materials such as human clothing, bedding, carpets and upholstery may result in its release to the environment through various waste streams; its use as a bacteriastatic, algaestatic and fungistatic compound will result in its direct release to the environment. If released to air, an estimated vapor pressure of 5.8X10-14 mm Hg at 25 °C indicates 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will exist solely in the particulate phase in the atmosphere. Particulate-phase 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will be removed from the atmosphere by wet and dry deposition. 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride hydrolyzes rapidly on contact with water and the hydrolytic cationic portion of the molecule (quaternary ammonium) will sorb readily to soil and sediment due to opposite electrical charges. The silyl portion of the molecule will become part of the soil and sediment matrices because of their high silica content. Volatilization from moist soil surfaces is not expected to be an important fate process because the compound exists as a cation and cations do not volatilize. 3-(Trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride is not expected to volatilize from dry soil surfaces based upon its vapor pressure. If released into water, 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride will completely ionize in an aqueous solution. Volatilization from water surfaces is not expected to be an important fate process given the compound will exist in ionic form and it hydrolyzes readily. In water, the hydrolysis half-life is <1 hour. The rapid hydrolysis will attenuate any bioconcentration of the parent compound. Occupational exposure to 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride may occur through inhalation (e.g. spray application) and dermal contact with this compound at workplaces where 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride is produced or used. Use data indicate that the general population may be exposed to 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride via dermal contact with consumer products containing or treated with 3-(trimethyoxylsilyl)propyl dimethyl octadecyl ammonium chloride. (SRC)

The Agency has completed its assessment of the dietary, occupational and ecological risks associated with the use of pesticide products containing trimethoxysilyl quats as the active ingredient. Based on a review of the data and other available information for the active ingredient, the Agency has concluded that there is sufficient information on the human health and ecological effects of the trimethoxysilyl quats to make decisions as part of the reregistration process under FIFRA, as amended by FQPA. The Agency has determined that products containing trimethoxysilyl quats are eligible for reregistration provided that current data gaps and confirmatory data needs are addressed. ... Based on the evaluation of the trimethoxysilyl quats, the Agency has determined there are no human health or ecological risks of concern.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. (Trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride is found on List C. Case No: 3184; Pesticide type: Fungicide, herbicide, antimicrobial; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): (Trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride; Data Call-in (DCI) Date(s): 8/12/93, 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.