Tetraethylammonium Bromide (HCID 6285)

概要

See also: Tetraethylammonium (has active moiety).

名称と識別子

優先名称: Tetraethylammonium Bromide
IUPAC: tetraethylazanium bromide
現地名: テトラエチルアンモニウムブロミド
英語名: Tetraethylammonium bromide
分子式: C8H20BrN
分子量: 210.16

名称と別名

TETRAETHYLAMMONIUM BROMIDE71-91-0TEABSympatektomanEtambroEthylonBromethylTetraniumBeparonEtamonEtylonTeamon

名称をさらに表示

テトラエチルアンモニウムブロミドシンパテクトマンテトリルアンモニウムブロミドテアモンテトラエチルアミニウム·ブロミドTEAブロミドブロムエチルエチロンテトラニウム臭化テトラエチルアンモニウムエタンブロテトラエチルアンモニウム·ブロミドN,N,N-トリエチルエタンアミニウム·ブロミドエタモンテトラエチルアンモニウムブロマイドテトラエチルアンモニウムブロマイド臭化物臭化テトラエチルアンモニウム臭化物ブロマイド臭化テトリルアンモニウムtetraethylazanium bromideTetra ethyl ammonium bromide SolidEthanaminium, N,N,N-triethyl-, bromide (1:1)tmd10

Tetrylammonium bromideTEA bromideTetraethyl ammonium bromideEthanaminium, N,N,N-triethyl-, bromideBromuro de tetrilamonioBromure de tetrylammoniumTMD 10Bromure de tetraethylammonium

データベース識別子

CAS: 71-91-0
PubChem CID: 6285
DTXSID: DTXSID9044457
ChEMBL: CHEMBL324254
UNII: 0435621Z3N
EC Number: 200-769-4

物性

構造計算による物性

極性表面積: 0 Å²
水素結合供与体数: 0
水素結合受容体数: 1
回転可能結合数: 4
重原子数: 10
形式電荷: 0
複雑度: 47.5

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Quaternary Amines

Density1.39 @ 20°C

Vapor Pressure0.00000079 [mmHg]

Physical Description · 2 件

Liquid

Deliquescent solid; [Merck Index] Colorless crystalline solid; Highly hygroscopic; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 285 °C · 285 °C (dec.)(lit.)
沸点: 310 °C/979.1 · >310 °C/979.1 hPa
比重(密度): 1 · 1,397 g/cm3
蒸気密度: 5.3 · 5.3 (vs air)
蒸気圧: 1 hPa · <1 hPa
屈折率: 1 · 1,442-1,444
貯蔵温度: 30 °C · Store below +30°C.
溶解性: 0.1 g/mL · アセトニトリル: 0.1 g/mL 温、透明、無色
外見: 液体
色: ホワイト～クリーム
臭い (Odor): 無臭
PH: 6.5 · 6.5 (100g/l, H2O, 20℃)
水溶解度: 2795 g/L · 2795g/L（25℃）
Merck: 14 · 14,9199
BRN: 3563430 · 3563430
安定性: 安定。強力な酸化剤とは相容れない。
InChI: 1S/C8H20N.BrH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
InChIKey: HWCKGOZZJDHMNC-UHFFFAOYSA-M
SMILES: [Br-].CC[N+](CC)(CC)CC
CAS データベース: 71 · 71-91-0(CAS DataBase Reference)
NISTの化学物質情報: Tetraethylammonium bromide(71-91-0)
EPAの化学物質情報: Ethanaminium, N,N,N-triethyl-, bromide (71-91-0)

化学的性質

化学的特性white to light yellow crystalline solid

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 1.6% (5 of 317) of reports.

Warning

H302 (18.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 317 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

危険有害性情報

Regulatory Information · 4 件

Chemical: Ethanaminium, N,N,N-triethyl-, bromide

Ethanaminium, N,N,N-triethyl-, bromide (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanaminium, N,N,N-triethyl-, bromide (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19226

Tetraethylammonium bromide: HSNO Approval: HSR006306 Approved with controls

Other Safety InformationIMAP assessments - Tetraethylammonium salts: Human health tier II assessment

Hazards Summary · 1 件

Causes mydriasis, tremor, and changes in motor activity in acute intraperitoneal studies of mice; Causes ganglion blockage and lowered blood pressure in acute intravenous studies of cats; [RTECS] A skin and strong eye irritant; Targets the heart and CNS; [Sigma-Aldrich MSDS]

Hazard Classes and Categories · 2 件

Acute Tox. 4 (18.3%)

Eye irritation - category 2B

安全と保護具

Protective Action Criteria (PAC) · 3 件

8.4 [mg/m3]

92 [mg/m3]

550 [mg/m3]

安全データ

F: 3
wgk: 3
tsca: TSCA listed
rtecs: BS5950000
hs_code: 29239000
risk_code: 36/37/38
化審法: (2)-186
hazard_code: Xi
safety_code: 26-36-37/39
Hazard Classifications: Aquatic Chronic 3
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological ClassificationA class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.

用途と製造

UsesA ganglion blocking agent; [Merck Index]

U.S. Production2023: 1,000,000 - <5,000,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2 件

All Other Basic Organic Chemical Manufacturing

Ethanaminium, N,N,N-triethyl-, bromide (1:1): ACTIVE

応用分野 · 4 件

解説臭化テトラエチルアンモニウム，シュウカテトラエチルアンモニウム，C8H20BrN(210.16)．(C2H5)4N＋ Br－．略称TEAB．テトラエチルアンモニウムブロミドともいう．トリエチルアミンに臭化エチルを作用させると得られる第四級アンモニウム塩．潮解性結晶．分解点285 ℃．d425"1.3880．水，アセトン，エタノール，クロロホルムに易溶，ベンゼンに難溶．pH 6.5(10％水溶液)．ガングリオン阻害剤，血圧降下作用があり，高血圧や末梢血管の診断治療に用いられる．

用途臭化テトラエチルアンモニウム (tetraethylammonium bromide) は第四級アンモニウム塩である。テトラエチルアンモニウム（英語版）カチオンの供給源として利用される。

使用Tetraethylammonium Bromide, can be used as a source of tetraethylammonium ions for various pharmaceutical studies. It has also the ability to block K+ channels in various tissues.

一般的な説明The use of ion-pairing reagents as mobile phase additives allows the separation of ionic and highly polar substances on reversed phase HPLC columns. The purity of mobile phase additives is of utmost importance to their successful application. Sigma-Aldrich offers an outstanding range of tailor-made reagents for anionic (quaternary ammonium and phosphonium salts) and cationic (alkanesulfonates) determination. All mobile phase additives are subject to rigorous testing with special emphasis on the requirements of modern reversed phase HPLC:

調製方法 · 1 件

純化方法Recrystallise the bromide from EtOH, CHCl3 or diethyl ether, or recrystallise it from acetonitrile and dry it over P2O5 under reduced pressure for several days. It also recrystallises from EtOH/diethyl ether (1:2), EtOAc, water or boiling MeOH/acetone (1:3) or by adding an equal volume of acetone and allowing to cool. Dry it at 100o in vacuo for 12 days, and store over P2O5. [Beilstein 4 IV 332.]