デフェロキサミン塩酸塩

Deferoxamine Hydrochloride

HCID 62880

基本情報

CAS: 1950-39-6
標準SMILES: CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.Cl
InChIKey: KCRQZLMAZHZDCL-UHFFFAOYSA-N
分子式: C25H49ClN6O8
平均分子量: 597.1 g/mol
単同位体質量: 596.3300402

概要

Deferoxamine Hydrochloride is the hydrochloride salt form of deferoxamine, an iron chelating agent. Deferoxamine chelates iron from intra-lysosomal ferritin and hemosiderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI)

名称と識別子

優先名称: Deferoxamine Hydrochloride
IUPAC: N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;hydrochloride
現地名: デフェロキサミン塩酸塩
英語名: N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxysuccinamide monohydrochloride
分子式: C25H49ClN6O8
分子量: 597.14496

名称と別名

Deferoxamine hydrochlorideDeferoxamine HCl1950-39-6Deferoxamine hydrochloride [USAN]Ba-29837G9VYJ96FOJDesferrioxamine hydrochlorideEINECS 217-767-4Ba 29837NSC-268993DTXSID50173157Deferoxamine hydrochloride (USAN)

名称をさらに表示

N-[5-[3-[(5-アミノペンチル)ヒドロキシカルバモイル]プロピオニルアミノ]ペンチル]-3-[[5-(N-ヒドロキシアセチルアミノ)ペンチル]カルバモイル]プロピオノヒドロキサム酸·塩酸塩デフェロキサミン塩酸塩N′-[5-[[4-[[5-(アセチルヒドロキシアミノ)ペンチル]アミノ]-1,4-ジオキソブチル]ヒドロキシアミノ]ペンチル]-N-(5-アミノペンチル)-N-ヒドロキシスクシンアミド・塩酸塩N-[5-[3-[(5-アミノペンチル)ヒドロキシカルバモイル]プロピオニルアミノ]ペンチル]-3-[[5-(N-ヒドロキシアセチルアミノ)ペンチル]カルバモイル]プロピオノヒドロキサム酸・塩酸塩Butanediamide,N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-,hydrochloride (1:1)

DEFEROXAMINE HYDROCHLORIDE [MI]NSC 268993DEFEROXAMINE HYDROCHLORIDE [WHO-DD]NSC268993N'-(5-((4-((5-(Acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxysuccinamide monohydrochlorideN'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxysuccinamide monohydrochlorideN-(5-{3-((5-Aminopentyl)hydroxycarbamoyl)propionamido}pentyl)-3-{(5-(N-hydroxyacetamido)pentyl)carbamoyl}propionohydroxamic acid monohydrochlorideN-(5-(3-((5-AMINOPENTYL)HYDROXYCARBAMOYL)PROPIONAMIDO)PENTYL)-3-((5-(N-HYDROXYACETAMIDO)PENTYL)CARBAMOYL)PROPIONOHYDROXAMIC ACID MONOHYDROCHLORIDE

データベース識別子

CAS: 1950-39-6
PubChem CID: 62880
DTXSID: DTXSID50173157
ChEMBL: CHEMBL2002581
UNII: G9VYJ96FOJ
EC Number: 217-767-4

物性

構造計算による物性

極性表面積: 206 Å²
水素結合供与体数: 7
水素結合受容体数: 9
回転可能結合数: 23
重原子数: 40
形式電荷: 0
複雑度: 739

物理化学的性質

融点: 172 · 172-175°

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 33.3% (1 of 3) of reports.

Danger

H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]

P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationREACH registered substance: N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxysuccinamide monohydrochloride (EC: 217-767-4)

Hazard Classes and CategoriesSkin Irrit. 2 (66.7%)

安全データ

危険有害性情報: コード危険有害性情報危険有害性クラス区分注意喚起語シンボル P コード H315

化学と産業

サプライヤー3 社

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北京泰和景明医药科技有限公司15011440205 · [email protected]

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