基本情報
- CAS
128345-62-0- 標準SMILES
CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Bi+3]- InChIKey
XAUTYMZTJWXZHZ-UHFFFAOYSA-K- 分子式
- C19H27BiN4O10S
- 平均分子量
- 712.5 g/mol
- 単同位体質量
- 712.12519
概要
Ranitidine Bismuth Citrate is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
名称と識別子
- 優先名称
- Ranitidine Bismuth Citrate
- IUPAC
- bismuth;1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate
- 現地名
- クエン酸ラニチジンビスマス
- 英語名
- Ranitidinebismuthcitrate
- 分子式
- C19H30N4O10S
- 分子量
- 506.53
名称と別名
TritecRanitidine bismuth citrate128345-62-0GR 122311XGR-122311X7AJ51I17KGDTXSID801027716N-(2-((5-((Dimethylamino)methyl)furfuryl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine, compound with bismuth(3(+)) citrate (1:1)AzanplusGR122311XRefChem:55967DTXCID101513293
名称をさらに表示
クエン酸ラニチジンビスマスラニチジンビスマトレックスラニチジン・くえん酸ビスマスガストリムトピロリドラニチジンビスマスクエン酸ラニチジン/くえん酸ビスマスPyloridGastrimutoRanitidine bismutrexRANTIDINEBISMUTHCITRATETIANFU CHEM-- Ranitidinebismuthcitrate2-Hydroxy-1,2,3-propanetricarboxylic acid bismuth(3+) salt compd with N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine
AzamplusElicodilHeliradPylorisanUNII-7AJ51I17KGRANITIDINEBISMUTHCITRATERANITIDINE BISMUTH CITRATE [USAN]Ranitidine bismuth citrate [USAN:BAN]
物性
構造計算による物性
- 極性表面積
- 252 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 14
- 回転可能結合数
- 11
- 重原子数
- 35
- 形式電荷
- 0
- 複雑度
- 558
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- InChIKey
- DLLAJOLFPOWVLQ-UHFFFAOYSA-N
- SMILES
- C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1=CC=C(CSCCNC(NC)=CN(=O)=O)O1)N(C)C
化学と産業
薬理情報
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
MeSH Pharmacological Classification
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
応用分野
説明Ranitidine bismuth citrate, a novel salt formed from ranitidine and a bismuth citrate complex, is a new agent introduced in the United Kingdom for the treatment of duodenal and benign gastric ulcers, for eradication of Helicobacfer pylori, and for prevention of relapse of duodenal ulcer when administered in combination with an antibiotic such as clarithromycin or amoxicillin. Ranitidine is a potent histamine H2-receptor antagonist with ability to inhibit gastric acid secretion. Other type of agents such as tripotassium dicitrato bismuthate exert their therapeutic effects in peptic ulceration by providing a protective coating to the ulcer crater, stimulating endogenous prostaglandin production, and inhibiting pepsin activity. More significantly, they inhibit micro-organism Helicobacfer pylori, a prevalent, specifically human pathogen associated with gastritis and gastric ulcers. The title compound possesses a novel combination of properties of the above two types of drugs and displays excellent therapeutic efficacy in clinical studies. Ranitidine bismuth citrate is being investigated for use in gastritis and non-ulcerating dyspepsia, acute healing of gastrointestinal ulcer and in prevention of the recurrence of peptic ulcer disease.
使用Antagonist (to histamine H2receptors).
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