4-クロロ安息香酸

Fires involving this compound can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use water spray, powder.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self contained breathing apparatus for fire fighting if necessary.

Accidental Release Measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Waste treatment methods. Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, static; Concentration: >20000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation/

LC50; Species: Daphnia pulex (Water Flea) age 12 hr; Conditions: freshwater, renewal, 20 °C; Concentration: >100000 ug/L for 96 hr /formulation/

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 42(SRC), determined from a log Kow of 2.65(2) and a regression-derived equation(3), indicates that p-chlorobenzoic acid is expected to have very high mobility in soil(SRC). The pKa of p-chlorobenzoic acid is 3.98(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize(SRC). p-Chlorobenzoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.9X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(3). Using an activated sludge inoculum, 6% CO2 evolution after 5 days incubation(6) suggests that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 42(SRC), determined from a log Kow of 2.65(2) and a regression-derived equation(3), indicates that p-chlorobenzoic acid is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 3.98(4) indicates p-chlorobenzoic acid will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). The BCF for p-chlorobenzoic acid was < 10 in golden ide fish(5), which suggests the potential for bioconcentration in aquatic organisms is low(SRC). A range of 2.03% to 79% 14-CO2 recovered using varying concentrations in the river die-away test(6) suggests that biodegradation may be an important environmental fate process in water, subject to conditions(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), p-chlorobenzoic acid, which has an estimated vapor pressure of 2.9X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase p-chlorobenzoic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 days(SRC), calculated from its rate constant of 1X10-12 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). Particulate-phase p-chlorobenzoic acid may be removed from the air by wet and dry deposition(SRC). p-Chlorobenzoic acid absorbs light at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

IDENTIFICATION AND USE: P-chlorobenzoic acid is white, odorless, crystalline powder. It is used as a laboratory reagent, and in manufacture of chemicals. P-Chlorobenzoic acid is a degradation product of indomethacin. HUMAN EXPOSURE AND TOXICITY: No human studies could be located. ANIMAL STUDIES: P-Chlorobenzoic acid is a potent inhibitor of rat brain and liver mitochondrial 4-hydroxybenzoate:polyphenyl transferase. After single oral administration to animals urokaninase and histidase activities were found in blood serum within 8 hr after the intoxication, reaching the maximum within 15 hr and exhibited the constant level during 25 hr. Then the enzymatic activity was gradually decreased but it did not reach the control values within 70 hr.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of September 4, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=74-11-3]

p-Chlorobenzoic acid was detected, not quantified in 6 out of 18 samples of advanced treatment concentrate collected from Lake Tahoe, CA, Oct 1974; Pomona, CA, Sept 1974; Escondido, CA July 1975; and Dallas, TX, Nov 1974(1). p-Chlorobenzoic acid was detected in the emissions of a municipal waste incineration plant in Germany at a concentration of 1.16 ug/cu m(2).

The Koc of p-chlorobenzoic acid is estimated as 42(SRC), using a log Kow of 2.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that p-chlorobenzoic acid is expected to have very high mobility in soil. The pKa of p-chlorobenzoic acid is 3.98(4), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

AEROBIC: The biodegradation of p-chlorobenzoic acid varies considerably; biodegradation can be rapid under some conditions and slow under other conditions(SRC). p-Chlorobenzoic acid was degraded at 65 BOD% after 5 days in river water collected from the Songhua river of Jillin Province, China(1). Biodegradation of p-chlorobenzoic acid, present at 50 ug/L in activated sludge, was approximately 6% CO2 after 5 days(2). The percentage of 14-C02 recovered from river die-away tests using freshwater from Fall Creek, Ithaca, NY, and 14-C labeled p-chlorobenzoic acid following 4, 6, 8 and 12 days of aerobic incubation were 47.6%, 51.3%, 60.3%, no data at 47 pg/mL; 17.1%, 33.0%, 48.0%, no data at 4.7 ng/mL; 2.03%, 3.6%, no data, 79% at 470 ng/mL; and 1.2%, 1.4%, no data, 5.9% at 47 ug/mL(3). No degradation was found after > 25 days for p-chlorobenzoic acid present at 16 mg/L in both wastewater sludge and a soil inoculum(4). 100% decomposition (as measured by UV absorption loss) of p-chlorobenzoic acid was observed after 64 days in the soil(5).

PURE CULTURE: It was found that an Acinetobacter sp., utilized p-chlorobenzoic acid as an exclusive carbon and energy source, resulting in the total biodegradation of p-chlorobenzoic acid in the soil(1).

ANAEROBIC: No anaerobic degradation was observed at > 65 weeks in freshwater lake sediment and > 8 weeks in municipal digested sludge(1). 4-Chlorobenzoic acid was degraded under denitrifying conditions in the sediment of the Hudson river, New York City, NY, near Albany, NY, and the East River, NY and was metabolized at rates of 32 umol/liter/day(2). The half-life of 4-chlorobenzoic acid was reported to be 235 days in anaerobic sediment (3). This compound is expected to have slow anaerobic biodegradation.

Occurrence of plasmid pAC21 specifying bioconversion of p-chlorobiphenyl to p-chlorobenzoate, has been previously shown in a strain of Klebsiella pneumoniae isolated from PCB-contaminated areas of Hudson River. Conjugative plasmid pAC25, characterized in a strain of Pseudomonas putida, specifies biodegradation of 3-chlorobenzoic acid by a modified ortho pathway that involves maleylacetate, but not beta-ketoadipate, as an intermediate. Introduction of putida strains harboring pAC25 & other degradative plasmids in a chemostat & continued selection on 4-chlorobenzoic acid as major carbon source has led to the emergence of cells that harbor plasmid pAC27 encoding the 4-chlorobenzoate degradative pathway.

SEDIMENT: p-Chlorobenzoic acid was detected, not quantified in contaminated sediment enrichments collected from Bloody Run Creek and Devil's Hole Creek, located in the Niagara River watershed, Niagara Falls, NY. Samples were collected during May and November 1992 and May, August, November 1993(1).

A pKa of 3.98(1) indicates p-chlorobenzoic acid will exist almost entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize(SRC). p-Chlorobenzoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.9X10-3 mm Hg(SRC), determined from a fragment constant method(3).

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorobenzoic acid is produced, as an intermediate or final product, by process units covered under this subpart. /Chlorobenzoic acid/

Used as an intermediate (dyes, fungicides, and pharmaceuticals) and preservative (adhesives and paints); [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

CHEM INT FOR M-CHLOROPHENOL

CHEM INT FOR IODAMIDE (MEDICAL RADIOPAQUE)

CHEM INT FOR PLASTICIZERS

Laboratory reagent, manufacture of chemicals

(1979) 2.00X10+5 GRAMS (PRINCPL CUSTMS DISTS)

(1981) 6.01X10+5 GRAMS (PRINCPL CUSTMS DISTS)

(1979) NOT PRODUCED COMMERCIALLY IN USA

(1981) NOT PRODUCED COMMERCIALLY IN USA

Preparation by catalytic oxidation of 1-chloro-4-ethylbenzene; ... Manufacture by oxidation of p-chlorobenzaldehyde.

Produced by the oxidation of 4-chlorotoluene.