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Alhydrogel

HCID 6328211
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
14762-49-3
標準SMILES
O.O.O.[Al]
InChIKey
MXRIRQGCELJRSN-UHFFFAOYSA-N
分子式
AlH6O3
平均分子量
81.028 g/mol
単同位体質量
81.0132325

概要

Aluminium hydroxide is a member of aluminium hydroxides. It has a role as an antacid and a flame retardant.

名称と識別子

優先名称
Alhydrogel
英語名
Gibbsite (Al(OH)3)
分子式
AlH3O3
分子量
78

名称と別名

RefChem:556672TricreamalateAscriptinCalcitrelTrisogelKudroxMaaloxMaalox PlusSimeco SuspensionDi-Gel LiquidAKP-DA14762-49-3
名称をさらに表示
hydrargiliteGibbsite (AI(OH)3)alpha-aluminum hydroxide
Gibbsite (Al(OH)3)C 4dHSDB 575Aluminum hydroxide (Al(OH)3)EINECS 244-492-7UNII-5QB0T2IUN0Arthritis Pain Formula Maximum StrengthC 31

データベース識別子

CAS
14762-49-3、21645-51-2
PubChem CID
6328211
ChEMBL
CHEMBL1200706
ChEBI
CHEBI:33130

物性

構造計算による物性

極性表面積
3 Ų
水素結合供与体数
3
水素結合受容体数
3
回転可能結合数
0
重原子数
4
形式電荷
0
複雑度
3.2

実験および物理化学的性質

Polymers · 3 件

Plastics -> Flame retardants

Plastics -> Other functions -> Pigment

Plastics -> Polyolefin-I; PUR; PA

Flame RetardantsFlame retardants

物理化学的性質

比重(密度)
2.441 · monocl: 2.441; tricl: 2.42 [KIR78] [ROB78]
融点
165 °C · 165 °C (decomp)
InChI
InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
InChIKey
WNROFYMDJYEPJX-UHFFFAOYSA-K
SMILES
[Al](O)(O)O

化学的性質

化学的特性white, pearly vitreous; hardness 2.5–3.5 Mohs; monocl: a=0.868 nm, b=0.507 nm, c=0.972 nm; tricl: a=1.733nm, b=1.008nm, c=0.973 nm [KIR78]

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

危険有害性情報

Regulatory Information · 2 件

Chemical: Gibbsite (Al(OH)3)

Gibbsite (Al(OH)3): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Gibbsite (Al(OH)3): Human health tier I assessment

安全と保護具

Minimum Risk LevelIntermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134)

毒性情報

Treatment · 1 件

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1 件

Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740)

Exposure RoutesOral (L739) ; inhalation (L739)

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739)

MeSH Pharmacological Classification · 2 件

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.

用途と製造

Uses · 2 件

Plastics -> Typical concentration range in plastic materials -> 0.25 - 50.0%

Aluminium hydroxide is used as an antacid and included as an adjuvant in some vaccines. (L756)

Use Classification · 3 件

Plastics -> Other functions -> Pigment

Plastics -> Polymer Type -> Polyolefin-I; PUR; PA

Plastics -> Flame retardants

関連反応

0 件
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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
Toxicity Summary · 1 件

The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236)

Signs and Symptoms · 1 件

Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740)

Carcinogen Classification · 1 件

Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468).

Toxicity DataLD50: 1100 mg/kg (Intraperitoneal, Rat) (L757) LD50: >5000 mg/kg (Oral, Rat) (A554)

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