メチルアミン 塩酸塩
Methylamine hydrochloride
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基本情報
- CAS
593-51-1- 標準SMILES
CN.Cl- InChIKey
NQMRYBIKMRVZLB-UHFFFAOYSA-N- 分子式
- CH6ClN
- 平均分子量
- 67.52 g/mol
- 単同位体質量
- 67.0188769
名称と識別子
- 優先名称
- Methylamine hydrochloride
- IUPAC
- methanamine;hydrochloride
- 現地名
- メチルアミン 塩酸塩
- 英語名
- Methylamine hydrochloride
- 分子式
- CH5N.ClH
- 分子量
- 67.52
名称と別名
Methylamine hydrochloride593-51-1Monomethylamine hydrochlorideMethylamine, hydrochlorideNSC-89685M439EX322KRefChem:818507209-795-0CHEBI:59337Methylammonium chlorideMonomethylammonium chlorideN-Methylammonium chloride
名称をさらに表示
メチルアミン 塩酸塩メタンアミニウムメチルアンモニウムメチルアミン·塩酸塩アミノメタン·塩酸塩メタンイミニウムメチルアミン·塩酸メチルアミニウムメタナミン塩酸塩メチルアミン塩酸塩アミノメタン塩酸塩モノメチルアミン塩酸塩モノメチルアミン酸メチルアミン塩酸塩(モノメチルアミン塩酸塩)塩化メチルアンモニウムメチルアミン塩酸塩 STANDARDメチルアミン 塩酸塩メチルアミン塩酸塩 Standard, 100 µg/mL in MeOHメチルアミン・塩酸塩メタンアミン・塩酸塩MAClCH3NH3ClMACIMethanaminium chlorideMethyl-ammoniumMONOMETHYLAMINE HCL
methanamine hydrochlorideMethylamine HClMETHANAMINE, HYDROCHLORIDEAminomethane HydrochlorideCH6ClNMFCD00012849MethylaminehydrochlorideMethyl Amine hydrochloride
データベース識別子
- CAS
593-51-1- PubChem CID
- 6364545
- UNII
- M439EX322K
- EC Number
- 209-795-0
物性
構造計算による物性補完中
- 極性表面積
- 26 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 1
- 回転可能結合数
- 0
- 重原子数
- 3
- 形式電荷
- 0
- 複雑度
- 2
実験および物理化学的性質
Vapor Pressure0.00101 [mmHg]
Physical DescriptionDeliquescent solid; [Merck Index] White crystals with an amine-like odor; Hygroscopic; [Alfa Aesar MSDS]
物理化学的性質
- 融点
- 231 · 231-233 °C(lit.)
- 沸点
- 225 · 225-230 °C15 mm Hg(lit.)
- 比重(密度)
- 0.8306 · 0.8306 (rough estimate)
- 蒸気圧
- 0.134 Pa · 0.134Pa at 25℃
- 屈折率
- 1.55 · 1.5500 (estimate)
- 闪点
- 225 · 225-230°C/15mm
- 貯蔵温度
- 30 °C · Store below +30°C.
- 溶解性
- 溶ける
- 外見
- 粉
- 色
- 白色結晶
- 臭い (Odor)
- 無臭
- PH
- 5 · 5-7 (10g/l, H2O, 20℃)
- 水溶解度
- 溶ける
- Merck
- 14 · 14,6014
- BRN
- 3588822 · 3588822
- 安定性
- 安定していますが、湿気に敏感な場合があります。強力な酸化剤とは相容れない。
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 0.7% (1 of 138) of reports.
Warning
H302 (96.4%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (65.2%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (64.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 138 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 138 reports by companies.；There are 10 notifications provided by 137 of 138 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危険有害性情報
Regulatory Information
Chemical: Methanamine, hydrochloride
Status: Active Update: 14-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/17443；Status: Active Update: 11-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24658
Methylammonium chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA severe eye irritant; Harmful by ingestion; [Alfa Aesar MSDS] See Methylamine.
Hazard Classes and CategoriesAcute Tox. 4 (96.4%)；Skin Irrit. 2 (65.2%)；Eye Irrit. 2 (66.7%)；STOT SE 3 (64.5%)
化学と産業
用途と製造
Uses
Used in organic synthesis; Methylamine is used in tanning; [Merck Index]
Leather Tanning and Processing [Category: Industry]
応用分野
用途有機合成原料、合成中間体、医薬.医薬中間体、はんだフラックス、加硫促進剤、酸性ガス吸収剤 など。
使用Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.
調製方法
製造方法Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.
純化方法Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]
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