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HCID 6384作成日：2026年10月27日

トリフルオロメチルブロミド

フロン13B1 · フロン-13B1 · トリフルオロメチルブロミド · モノブロモトリフルオロメタン · フレオン-13B1 · ブロモトリフルオロメタン · フレオンR-13B1 · ブロモフルオロホルム

https://huagongshe.com/ja/chemical/6384

トリフルオロメチルブロミド の分子構造式

識別子と物理属性

CAS No.75-63-8
分子式CBrF3
平均分子量148.91 g/mol
単同位体質量147.91355 g/mol
SMILESFC(F)(F)Br
InChIKeyRJCQBQGAPKAMLL-UHFFFAOYSA-N
PubChem CID6384
EC No.200-887-6
DTXSIDDTXSID5026415
現地名トリフルオロメチルブロミド

化学・物理的性質

XLogP2.2
極性表面積0
水素結合供与体数0
水素結合受容体数3
回転可能結合数0
重原子数5
形式電荷0
複雑度28
LogP（分配係数）log Kow= 1.86
臭いOdorless gas.
密度1.5800 g/ml @ 20 °C (liq)Critical volume: 200 cu m/molcritical density: 0.745 g/cu cmspecific heat of liquid: 0.208 cal/g at 25 °Cspecific heat of vapor: 0.112 cal/g at 25 °C and 1 atm.Relative density (water = 1): 1.51.58 @ 20°C5.14(relative gas density)1,58 g/cm3
Viscosity0.157 mPa.s @ 25 °C (liq)0.0154 mPa.s @ 25 °C - 101.3 kPa (vapor)
Color/FormColorless gas [Note: Shipped as a liquefied compressed gas.]
溶解度0.03 % (NIOSH, 2024)Sol in chloroform0.03% in waterSolubility in water: noneクロロホルム (West, 1986) および他の多くの溶媒、特に塩素化炭化水素に可溶。20 °C で 0.03 wt % (NIOSH、1997)
CorrosivityNoncorrosive
沸点-72 °F at 760 mmHg (NIOSH, 2024)-57.8 °C @ 760 mm Hg-58 °C-57.8 °C @760 [mm Hg]-58°C
DecompositionTHE FIRE EXTINGUISHER HALON 1301 BEGINS TO DECOMP AT 400-500 DEG TO HALOGEN GASES, WHICH REACT WITH HYDROGEN TO FORM HYDROGEN HALIDES. IN OXYGEN, CARBON DIOXIDE, CARBONYL FLUORIDE & CARBONYL BROMIDE MAY FORM. HAZARDS FROM DECOMP PRODUCTS ARE NEGLIGIBLE AS COMPARED TO THOSE OF OTHER HAZARDS ASSOCIATED WITH A FIRE.Toxic gases and vapors (such as hydrogen bromide, ... hydrogen fluoride, and carbon monoxide) may be released when trifluoromonobromomethane decomposes.UNDER CERTAIN CONDITIONS, FLUOROCARBON VAPORS MAY DECOMPOSE ON CONTACT WITH FLAMES OR HOT SURFACES, CREATING THE POTENTIAL HAZARD OF INHALATION OF TOXIC DECOMPOSITION PRODUCTS. /FLUOROCARBONS/
融点-267 °F (NIOSH, 2024)-172 °C-168 °C-168°C
蒸気密度5.14 (NIOSH, 2024) - Heavier than airwill sink (Relative to Air)3.8 (AIR= 1)Relative vapor density (air = 1): 5.1
蒸気圧greater than 1 atm (NIOSH, 2024)1.22X10+4 mm Hg @ 25 °CVapor pressure, kPa at 20 °C: 1434>1 atm750 [mm Hg] @-58.1 °C>760 at 20 °C (NIOSH, 1997)
屈折率1.2380
外観・状態ガス
色エーテル様のにおいのある無色の気体
比熱容量Cp(gas): 0.47 J/(g·K), at 25℃
ヘンリー定数(atmm3/mol): 0.500 at 25 °C (Hine and Mookerjee, 1975)
CAS データベース75-63-8(CAS DataBase Reference)
EPAの化学物質情報Halon 1301 (75-63-8)

化学的特性

Trifluorobromomethane is a colorless gas with a slight ethereal odor. Shipped as a liquefied compressed gas.

安全性と法規制

GHS 分類WarningH280 (99.6%): Contains gas under pressuremay explode if heated [Warning Gases under pressure]H315 (15%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (15%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (15%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H336 (39.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposureNarcotic effects]H420 (54.3%): Harms public health and the environment by destroying ozone in the upper atmosphere [Warning Hazardous to the ozone layer]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P410+P403, P501, and P502 (click each P-code to see the statement)Aggregated GHS information provided per 267 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
規制情報Chemical: Methane, bromotrifluoro-Methane, bromotrifluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methane, bromotrifluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 20-07-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/10495Bromotrifluoromethane: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
輸送ラベル（DOT）Non-Flammable Gas
火災危険Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

用途

用途

半導体ドライエッチング、航空機 、コンピューター室等の消火剤、冷媒、エアゾール噴射剤、プラスチックフォーム発泡剤

使用

Used as fire extinguishing agent for oil, electrical equipment, organic solvent, natural gas and a variety of organics, especially for important military and civilian sites.

一般的な説明

A colorless, odorless gas at room conditions Shipped as a liquid confined under its own vapor pressure. Noncombustible. Nontoxic but can asphyxiate by the displacement of air. Contact with the unconfined liquid can cause frostbite by evaporative cooling. Exposure of the container to prolonged heat or fire can cause BROMOTRIFLUOROMETHANE to rupture violently and rocket.

製法・合成法

純化方法

Purify the gas by passing it through a tube containing P2O5 on glass wool into a vacuum system where it is frozen out in a quartz tube and degassed by a cycles of freezing, evacuating and thawing. [Beilstein 1 III 83, 1 IV 73.]

Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket. CAUTION: Aerosols (UN1950) may contain a flammable propellant. (ERG, 2024)
· Some may burn but none ignite readily.
· Containers may explode when heated.
· Ruptured cylinders may rocket.
CAUTION: Aerosols (UN1950) may contain a flammable propellant.
Not combustible. Heating will cause rise in pressure with risk of bursting. Gives off irritating or toxic fumes (or gases) in a fire.
火災の可能性MONOBROMOTRIFLUOROMETHANE IS NOT FLAMMABLEIT IS A GOOD FIRE EXTINGUISHER.
健康有害性Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:Vapors may cause dizziness or asphyxiation without warning, especially when in closed or confined areas. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases. (ERG, 2024)· Vapors may cause dizziness or asphyxiation without warning, especially when in closed or confined areas.· Vapors from liquefied gas are initially heavier than air and spread along ground.· Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.· Fire may produce irritating, corrosive and/or toxic gases.
有害性の概要Slightly increased reaction times were recorded in volunteers exposed to 4% trifluorobromomethane for 3 minutes. [ACGIH] Possible frostbite from contact with liquid[NIOSH] An eye irritantEvaporating liquid can cause frostbiteInhalation of high concentrations can cause CNS depression[ICSC] See CHLOROFLUOROCARBONS.
輸送番号・ガイド（DOT）1009 126
反応性グループFluorinated Organic Compounds
UN 分類UN Hazard Class: 2.2
Special ReportsFreonsEncyclop'edie m'edico-chirurgicale Intoxications, 18 rue S'eguier, 75006 Paris, France, 3 pages (1982). Data on freons (nomenclature, physical & chemical properties, acute & chronic toxicity), used as aerosol propellants, refrigerants, extinguishing agents, and anesthetics are reviewed.Gros PCah Notes Doc 113: 535-42 (1983). The properties, toxicities and uses of the gaseous extinguishing agents (Halon 1301 & 1211) were reviewed.Morel C et alCah Notes Doc 105: 629-32 (1981) Review of bromotrifluoromethane is presented with 20 references.Geller I et alContract Report No. CR: NASA-CR-161078 (1981). The effects of low concn of CBrF3, under continuous exposure conditions, on the central nervous system and cardiovascular systems of animals to enable an assessment of these risks to man were investigated.Zakhari S, Aviado DMCardiovascular Toxicology of Aerosol Propellants, Refrigerants and Related SolventsTarget Organ Toxicology Series: Cardiovascular Toxicology, XII+ 388 pagesRaven Press: New York, NY 281-326 (1982). Review of the toxicology of aerosol propellants, refrigerants and related solvents on the cardiovascular system of humans.
OSHA StandardsPermissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1000 ppm (6100 mg/cu m).
Reactivity ProfileBROMOTRIFLUOROMETHANE may react with aluminum to produce substantial heat. Other halogenated hydrocarbons, such as fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane produce sufficient heat in this way to melt aluminum pieces. The vigor of the reaction appears to depend on the degree of fluorination and the vapor pressure [Chem. Eng. News 39(27):44 1961].
消火Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:Use extinguishing agent suitable for type of surrounding fire.SMALL FIRE: Dry chemical or CO2.LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devicesicing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2024)In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep cylinder cool by spraying with water.
応急処置措置Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
漏出応急措置· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Many gases are heavier than air and will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).· Ventilate closed spaces before entering, but only if properly trained and equipped.· Do not touch or walk through spilled material.· Stop leak if you can do it without risk.· Do not direct water at spill or source of leak.· Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material.· If possible, turn leaking containers so that gas escapes rather than liquid.· Prevent entry into waterways, sewers, basements or confined areas.· Allow substance to evaporate.· Ventilate the area.
応急処置Excerpt from NIOSH Pocket Guide for Trifluorobromomethane:Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediatelyif tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediatelydo NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2024)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts.(General first aid procedures)Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.Breathing: Respiratory support
安全保管Fireproof if in building. Cool.
暴露管理・個人防護· Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.1000.0 [ppm]
消火手順If material involved in fire: Extingiush fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.
清掃方法If trifluoromonobromomethane is leaked, the following steps should be taken: 1. Ventilate area of leak. 2. Stop flow of gas.
非火災時の漏出対応Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2024)
処分方法SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.Because of recent discovery of potential ozone decomposition in the stratosphere by fluorotrichloromethane, this material should be released to the environment only as a last resort. Waste material should be /recovered and/ returned to the vendor, or to licensed waste disposal company.
漏出処分Ventilation. NEVER direct water jet on liquid. Personal protection: chemical protection suit including self-contained breathing apparatus.
Preventive MeasuresPersons not wearing protective equipment and clothing should be restricted from areas of leaks until cleanup has been completed.If material not involved in fire: Attempt to stop leak if without undue personnel hazard.Personnel protection: Avoid breathing vapors. Keep upwind. Wear appropriate chemical protective gloves and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment.SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/For more Preventive Measures (Complete) data for BROMOTRIFLUOROMETHANE (10 total), please visit the HSDB record page.
相互作用IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/
標的器官central nervous system, heart
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is expected to have very high mobility in soil(SRC). Volatilization of bromotrifluoromethane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 0.499 atm-cu m/mole(3). Volatilization of bromotrifluoromethane from dry soil surfaces is expected to be rapid(SRC) based upon a vapor pressure of 1.22X10+4 mm Hg(4). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(5).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 49(SRC), determined from a structure estimation method(2), indicates that bromotrifluoromethane is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 0.499 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.2 hrs and 4.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 5.4(SRC), from its log Kow of 1.86(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to occur due to the lack of hydrolyzable functional groups(SRC). Based upon the highly halogenated structure of bromotrifluoromethane, biodegradation is expected to be slow(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bromotrifluoromethane, which has a vapor pressure of 1.22X10+4 mm Hg at 25 °C(2), is expected to exist solely in the gas phase in the ambient atmosphere. Gas-phase bromotrifluoromethane is slowly degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life of this reaction in air is estimated to be greater than 44 years(3), calculated from it's rate constant of <1.0X10-16 cu cm/molecule-sec at 25 °C(3). Bromotrifluoromethane has a maximum UV absorbance at 205 nm and does not appear to absorb UV light above 270 nm(4). It has an estimated photolysis lifetime in the atmosphere of 72 years(4). The primary decomposition process to occur in the stratosphere is UV photolysis(5). The stratospheric lifetime of bromotrifluoromethane has been estimated to range from 62 to 112 years(6). Therefore, when bromotrifluoromethane is released in the troposphere, it will diffuse gradually into the upper limits of the troposphere, and eventually, into the stratosphere above the ozone layer where it will degrade slowly via photolysis, contributing to ozone depletion(SRC).
有害作用Neurotoxin - Acute solvent syndromeOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Other Poison - Simple Asphyxiant
暴露経路The substance can be absorbed into the body by inhalation.inhalation, skin and/or eye contact (liquid)
Signs and SymptomsDizziness. Headache. Unconsciousness.ON CONTACT WITH LIQUID: FROSTBITE.Redness. See Skin.cardiac arrhythmiasliquid: frostbite
ICSC Environmental DataAvoid release to the environment because of its impact on the ozone layer.
Medical SurveillanceConsider the points of attack /heart, central nervous system/ in preplacement and periodic physical examinations.The following medical procedures should be made available to each employee who is exposed to trifluoromonobromomethane at potentially hazardous levels: 1. Initial Medical Screening: Employees should be screened for history of certain medical conditions ... which might place the employee at increased risk from trifluoromonobromomethane exposure. /These include/ cardiovascular disease. In persons with impaired cardiovascular function, especially those with a history of cardiac arrythmias, the breathing of trifluoromonobromomethane might cause exacerbation of symptoms due to its sensitizing properties. 2. Periodic Medical Examination: Any employee developing /these/ conditions should be referred for further medical examination.
Soil Adsorption/MobilityThe Koc of bromotrifluoromethane is estimated as 49(SRC), using a log Kow of 1.86(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromotrifluoromethane is expected to have very high mobility in soil.
TSCA Test SubmissionsBromotrifluoromethane (CAS # 75-63-8) was evaluated for acute inhalation toxicity and cardiac sensitization in groups of beagle dogs (12/group, sex unspecified) exposed by facemask to historically sensitizing concentrations (7.5% and 10% v/v in air) and a non-sensitizing concentration (5% v/v in air) for 30 or 60 minutes. The same group of 12 dogs was used for trials at all exposure levels. The test material, a vapor at the experimental temperature and pressure, was released from a pressurized storage tank into the metered air supply to the facemasks, which was sampled and analyzed by thermal conductivity gas chromatograph every 5 minutes during exposures. Five minutes prior to the exposures, the dogs received a control intravenous injection of epinephrine (0.008 mg/kg), with an identical injection administered as challenge after the appropriate exposure interval. The exposures extended 5 minutes beyond the challenge injection for observation of subsequent recovery. Upon the challenge epinephrine injection, 1 dog each receiving 7.5 for 30 and 60 minutes, respectively, showed marked response (life-threatening arrhythmia) to treatment. One questionable and 1 definite marked response were also observed in 1 dog each in the 10% group after 30 minutes (there was no 60-minute, 10% exposure group). All marked responses were characterized by short bursts of multiple ventricular beats of up to 4 seconds in duration. One dog each responding seriously to 30-minute exposures to 7.5% and 10%, respectively, also exhibited atrial flutter. No response was noted after epinephrine challenge during a 5% exposure. The authors noted that only 1 dog of 12 showed more than one response in repeat experiments.Bromotrifluoromethane (CBrF3, CAS # 75-63-8) was evaluated for subchronic inhalation toxicity in 4 female rhesus monkeys and 2 female baboons repeatedly exposed by inhalation to 10-80% v/v in oxygen for 10-minute intervals. Both anesthetized (2 monkeys and 2 baboons) and conscious primates inhaled from CBrF3/oxygen-filled bags of 300-400 L capacity supplied from pressurized steel cylinders, and exhaled to the outside atmosphere by means of a Pink valve or by endotracheal catheters (anesthetized animals). Cardiac function (ECG), arterial blood pressure and content, and cardiac output were monitored throughout the study. In the conscious animals, treatment was associated with evidence of cortical depression, including shivering, sedation, half-closed eyes, and lack of an inducible aggressive response. Intravenous injection of epinephrine (10 ug/kg bodyweight) induced a short sequence of ventricular fibrillation bursts from which all animals recovered spontaneously. Cardiac arrest could not be induced by further increasing the doses of epinephrine. Universal arrhythmias at 5-40 seconds after initiation of 20-80% exposures were intractable to the introduction of anesthesia. In monkeys, a 3-4 ug/kg bodyweight injection of epinephrine also elicited halved pressor responses during (but not after) 80% exposure. Similarly, during 80% exposures, no rise in blood pressure accompanied electrical stimulation of the femoral nerve (5 Hz, 10v, 2.5 msec). An identical stimulation regimen produced a 20 mm Hg elevation in blood pressure in untreated monkeys. Electrical stimulation of the femoral nerve in the arrhythmic monkeys of the 80% exposure group gave rise to incomplete or complete heart block of about 2-3 minute duration, which reverted spontaneously to bizarre arrhythmias dominated by ectopic beats. Arrhythmias were also noted to change without stimulation. Changes in heart rate occasionally heralded onset of arrhythmia during exposures to 20-80% CBrF3. Within the first minuteThe pharmacokinetics of bromotrifluoromethane (CBrF3, CAS # 75-63-8) was investigated in 7 catheterized male volunteers exposed to 0.5% vapor by inhalation from Tedlar bags for 30 minutes. A nonbreathing valve inhalation device and mass spectrometry continuously analyzed inspired and end alveolar expired concentrations, while blood samples were collected for substance level analysis at 1/2-minute intervals for 5 minutes, and at 5-minute intervals thereafter. No effects on cardiac function (continuous ECG), blood pressure or pulse rate were noted throughout treatment, and venous blood concentrations among respective study participants ranged approximately 7-fold (from 0.19-1.24 mg/L) at the end of the exposure.
Atmospheric ConcentrationsINDOOR: Bromotrifluoromethane was detected in the payload bay of the shuttle (concn not specified) from 28 separate missions(1).RURAL/REMOTE: The concn of bromotrifluoromethane in the atmosphere at altitudes ranging from about 10 to 34 km was found to be approximately 1 part per trillion/V during 1980 monitoring(1). Bromotrifluoromethane was found at concns of 0.8 and 0.7 parts per trillion in monitoring studies conducted over the northern and southern hemisphere of the eastern Pacific Ocean, respectively(2). Bromotrifluoromethane is the main source of bromine radicals in the atmosphere above 25 km(3).
Human Toxicity Excerpts... TEN TO FIFTEEN PERCENT TRIFLUOROBROMOMETHANE IN AIR CAUSED A DECR IN HUMAN SUBJECT'S PERFORMANCE OF 5 OF 6 PSYCHOMOTOR TASKS. AT 15%, A FEELING OF IMPENDING UNCONSCIOUSNESS DEVELOPED. ... SLIGHT INCR IN REACTION TIME DURING 3 MIN EXPOSURES AT 4% & 7% TRIFLUOROBROMOMETHANE. LIGHT HEADEDNESS, PARESTHESIA, & DIMINISHED PERFORMANCE ... DURING EXPOSURES UP TO 10% TRIFLUOROBROMOMETHANE. ... NO CARDIAC ARRHYTHMIAS WERE REPORTED DURING HUMAN EXPOSURES AT 4% TO 7% TRIFLUOROBROMOMETHANE FOR 3 MIN IN HYPOBARIC CHAMBERS OR AT 5% TO 7% FOR 5 MIN AT PRESSURIZED ALTITUDES OF 1,000-20,000 FEET IN AIRCRAFT FLIGHT TESTS.Possible adverse effects of exposure to Halon 1301 during firefighting in confined spaces were investigated. Halon 1301 (7%) did not affect the normal sleep pattern or the general health of human subjects. No Halon-induced changes in serum enzymes or serum albumin or total protein levels were observed suggesting that liver function was not altered. Subjects experienced transient light-headness and mild euphoria. Mental performance was decr, but returned to normal 1/2 hr after exposure. Apparently, Halon 1301 is a medically safe agent for use in fire fighting in confined spaces.EXPOSURE OF HUMANS TO HALON 1301 UNDER HYPOBARIC CONDITIONS DID NOT PRODUCE SIGNIFICANT CHANGES IN THE CARDIAC OR CENTRAL NERVOUS SYSTEMS. VOLUNTEERS WERE EXPOSED FOR 3 MIN TO 4 OR 7% HALON 1301 IN AIR IN A HYPOBARIC CHAMBER MAINTAINED AT 632 OR 380 MM HG.FLUOROCARBON VAPORS ARE FOUR TO FIVE TIMES HEAVIER THAN AIR. THUS HIGH CONCN TEND TO ACCUMULATE IN LOW-LYING AREAS, RESULTING IN HAZARD OF INHALATION OF CONCENTRATED VAPORS, WHICH MAY BE FATAL. ... THE HIGHEST EXPOSURE IN THE PLANT OCCURS WITH VENTING OF GASES FROM RETURNABLE CYLINDERS. /FLUOROCARBONS/For more Human Toxicity Excerpts (Complete) data for BROMOTRIFLUOROMETHANE (21 total), please visit the HSDB record page.
職業暴露区分（OEB）A
職業暴露限界（OEL）TWA: 1000 ppm (6100 mg/m3)
生命健康即時危険濃度40,000 ppm
TSCA 収載状態TSCA listed
輸送番号（UN）UN 1009 (BROMOTRIFLUOROMETHANE (REFRIGERANT GAS R 13B1))
毒性LC50 (inhalation) for mice 381 gm/m3, rats 416 gm/m3 (quoted, RTECS, 1985).
PRTR法第1種指定化学物質
危険文句（R）20
化審法一般化学物質
安全措置（S）23-36/37/39-38
危険等級2.2
DOT Classification2.2 (Nonflammable gas)
有害物質データ75-63-8(Hazardous Substances Data)