シクリジン塩酸塩
Cyclizine Hydrochloride
基本情報
- CAS
303-25-3- 標準SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1.Cl- InChIKey
UKPBEPCQTDRZSE-UHFFFAOYSA-N- 分子式
- C18H23ClN2
- 平均分子量
- 302.8 g/mol
概要
Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a central nervous system depressant, a H1-receptor antagonist, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
名称と識別子
- 優先名称
- Cyclizine Hydrochloride
- IUPAC
- 1-benzhydryl-4-methylpiperazine;hydrochloride
- 現地名
- シクリジン塩酸塩
- 英語名
- Cyclizine Hydrochloride
- 分子式
- C18H23ClN2
- 分子量
- 302.84162
名称と別名
Cyclizine hydrochloride303-25-3CYCLIZINE HClMarezine hydrochloride1-(diphenylmethyl)-4-methylpiperazine hydrochlorideValoidColloxW0O1NHP4WE1-(Diphenylmethyl)-4-methylpiperazine monohydrochlorideNSC-169102(+-)-1-Diphenylmethyl-4-methylpiperazine hydrochloridePiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride
名称をさらに表示
シクリジン塩酸塩塩酸シクリジンCyclizine HCl solutionEchnatolFortravelCYCLYZINE HCLEinecs 206-136-9cyclizinechloridemarezinehydrochlorideCyclizini hydrochloridum
CHEBI:51045NSC169102DTXCID2027753ValiodHCl, CyclizineHydrochloride, CyclizineRefChem:919340206-136-9
データベース識別子
- CAS
303-25-3- PubChem CID
- 6420019
- ChEMBL
CHEMBL1324714- ChEBI
CHEBI:51045- UNII
- W0O1NHP4WE
- EC Number
- 206-136-9
物性
構造計算による物性
- 極性表面積
- 6.5 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 3
- 重原子数
- 21
- 形式電荷
- 0
- 複雑度
- 253
実験および物理化学的性質
Human DrugsBreast Feeding; Lactation; Antiemetics; Antihistamines; Anti-Allergic Agents; Gastrointestinal Agents
物理化学的性質
- 融点
- 258 · 258-260℃
- 沸点
- 457.04 °C · 457.04°C (rough estimate)
- 比重(密度)
- 1.0551 · 1.0551 (rough estimate)
- 屈折率
- 1.5749 · 1.5749 (estimate)
- 貯蔵温度
- Refrigerator
- 溶解性
- 1 mg/ml · Methanol: 1 mg/ml
- 外見
- solid
- 主な用途
- 医薬品医薬品低分子化合物
- InChI
- 1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
- InChIKey
- UKPBEPCQTDRZSE-UHFFFAOYSA-N
- SMILES
- [Cl-].N3(CCN(CC3)C)C(c2ccccc2)c1ccccc1.[H+]
化学的性質
化学的特性Off-White Solidmoderately soluble in water
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory InformationPiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
毒性情報
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
安全データ
- wgk
- 3
- ridadr
- 3249
- 毒性
- mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
- hs_code
- 2933595960
- risk_code
- 61-23/24/25-42/43
- hazard_code
- T
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs used to prevent NAUSEA or VOMITING.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
応用分野
使用Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
上流・下流製品情報
上流原料
補足説明
定義ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
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