オクタフルオロプロパン

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

General First Aid:

SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Immediate precautionary measure

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 900(SRC), determined from a structure estimation method(2), indicates that octafluoropropane is expected to have low mobility in soil(SRC). Volatilization of octafluoropropane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 33 atm-cu m/mole(SRC), based upon its vapor pressure, 6630 mm Hg(3), and water solubility, 5.7 mg/L(4). Octafluoropropane is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation data in soil were not available(SRC, 2012).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 900(SRC), determined from a structure estimation method(2), indicates that octafluoropropane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 33 atm-cu m/mole(SRC), derived from its vapor pressure, 6630 mm Hg(4), and water solubility, 5.7 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 34(SRC), from an estimated log Kow of 2.82(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegradation data in water were not available(SRC, 2012).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), octafluoropropane, which has a vapor pressure of 6630 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Octafluoropropane has an Ozone Depletion Potential of zero(3), a calculated atmospheric lifetime of 2600 years(4), and calculated 100-yr Global Warming Potential of 7000(5). Octafluoropropane does not contain chromophores that absorb at wavelengths >290 nm(6), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The average emissions of octafluoropropane calculated over five year periods was as follows (Gg/yr): 1977-1982, 0.04; 1982-1987, 0.21; 1987-1992, 0.11; and 1992-1997, 0.48(1). Time-average global emissions of 0.12 for 1975-1979, 0.20 for 1980-1989, 0.26 for 1985-1989, 0.28 for 1990-1994, 0.65 for 1995-1999, 1.01 for 200-2004, and 0.76 Gg/yr 2005-2008 have been estimated(2).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of octafluoropropane is estimated to be 900(SRC). According to a classification scheme(2), this estimated Koc value suggests that octafluoropropane is expected to have low mobility in soil.

/SIGNS AND SYMPTOMS/ The following adverse reactions have been identified during the post-marketing use of perflutren-containing microsphere products. ... Cardiopulmonary: Fatal cardiac or respiratory arrest, shock, syncope, symptomatic arrhythmias (atrial fibrillation, tachycardia, bradycardia, supraventricular tachycardia, ventricular fibrillation, ventricular tachycardia), hypertension, hypotension, dyspnea, hypoxia, chest pain, respiratory distress, stridor, wheezing. Anaphylactoid: Anaphylactic/anaphylactoid reaction, anaphylactic shock, hypersensitivity, bronchospasm, throat tightness, angioedema, edema (pharyngeal, palatal, mouth, peripheral, localized), swelling (face, eye, lip, tongue, upper airway), facial hypoesthesia, rash, urticaria, pruritus, flushing, erythema. Neurologic: Coma, loss of consciousness, convulsion, seizure, transient ischemic attack, agitation, tremor, vision blurred, dizziness, headache, fatigue.

/SIGNS AND SYMPTOMS/... Events typically occurred within 30 minutes of perflutren-containing microsphere administration. These serious events may be increased among patients with unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias.

/SIGNS AND SYMPTOMS/ Serious cardiopulmonary reactions including fatalities have occurred uncommonly during or shortly following perflutren-containing microsphere administration, typically within 30 minutes of administration. The risk for these reactions may be increased among patients with unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, or serious ventricular arrhythmias). ... The reported reactions include: fatal cardiac or respiratory arrest, shock, syncope, symptomatic arrhythmias (atrial fibrillation, tachycardia, bradycardia, supraventricular tachycardia, ventricular fibrillation, ventricular tachycardia), hypertension, hypotension, dyspnea, hypoxia, chest pain, respiratory distress, stridor, wheezing, loss of consciousness, and convulsions.

/CASE REPORTS/ ... This report describes a case of sudden death approximately 5 minutes after the intravenous administration of 0.5 mL of perflutren contrast agent (Definity) during transthoracic echocardiography with suboptimal baseline images performed 10 days after coronary artery bypass graft surgery because of hypotension and tachycardia in a 73-year-old patient with severe left ventricular systolic dysfunction. Autopsy did not reveal a clear direct relationship between perflutren and death. ...

For more Human Toxicity Excerpts (Complete) data for Octafluoropropane (9 total), please visit the HSDB record page.

Octafluoropropane's production and use as a electrical insulating gas; refrigerant, plasma processing gas; fire protection agent, ultrasound contrast agent, and as an adjunct in repair of retinal detachment(1) may result in its release to the environment through various waste streams(SRC).

Drug Induced Liver Injury Rank (DILIrank 2.0)

Perflutren

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

An estimated BCF of 34 was calculated in fish for octafluoropropane(SRC), using an estimated log Kow of 2.82(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Henry's Law constant for octafluoropropane is estimated as 33 atm-cu m/mole(SRC) derived from its vapor pressure, 6.63X10+3 mm Hg(1), and water solubility, 5.7 mg/L(2). This Henry's Law constant indicates that octafluoropropane is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). Octafluoropropane's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of octafluoropropane from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Acute Exposure/ Wistar rats were used to study inhalation toxicity of octafluoropropane (OFP, freon-218) at the following concentration: 300 g/cu m (4-hrs), 30 g/cu m (0.5 to 4 hrs), 3 g/cu m (8 hrs), and 0.3 g/cu m (16 hrs). According to the histological analysis, OFP at the concentrations of 300 and 30 g/cu m had a politrophic toxic effect. Target organs were the lung, trachea, bronchus, heart, kidney, and the adrenaL There were dystrophic and necrobiotic lesions in the upper airways epithelium. Subacute and chronic vesicular bronchiolitis developed on days 7 and 14, respectively. Visceral organs and brain were found plethoric and the lung was found hemorrhagic. Similar lesions were seen in the trachea, bronchus, lung, liver, spleen, kidney, adrenal, heart, and the brain. Lipid redistribution was observed in the adrenal cortex and vascular reactions of renal tissue with juxtamedullar blood shunting. Toxicity of small OFP concentrations (3 and 0.3 g/cu m) was distinguished by an extended after effect, these concentrations did not cause visible pathomorphologic changes but gave rise to an extended pathologic process detectable by biochemistry. In all concentrations, OFP impacted erythrocyte metabolism changing the lipid composition of cell membrane and activating membrane-bound adenosinetriphos-phatases. The activities of hepatocyte and myocardiac cytoplasmatic enzymes were altered in blood plasma. Increased malonic dialdehyde in blood plasma and decreased cell antioxidant GSH in erythrocytes suggested exaggerated lipid peroxidation.

/LABORATORY ANIMALS: Acute Exposure/ Glomerular capillary hemorrhage (GCH) has been reported and confirmed as a consequence of contrast-enhanced diagnostic ultrasound (CEDUS) imaging of rat kidney. This study assessed renal tissue injury in the larger porcine model. The right kidneys of anesthetized pigs were imaged in 8 groups of 4 pigs. A Vingmed System Five ultrasound machine (General Electric Co, Cincinnati, OH) was used at 1.5 MHz in the B-mode to intermittently scan the kidney at 4-second intervals. An Acuson Sequoia 512 machine (Siemens Medical Solutions, Mountain View, CA) was used in the 1.5-MHz Cadence contrast pulse sequencing mode with intermittent agent clearance bursts at 4-second intervals. Kidneys were scanned transabdominally or after laparotomy through a saline standoff. The second machine's probe was placed in contact with the kidney for 1 group. A perflutren lipid microsphere contrast agent (Definity; Lantheus Medical Imaging, Inc, North Billerica, MA) was infused at 4 uL/kg/min (diluted 33:1 in saline) for 4 minutes during scanning. Blood-filled urinary tubules were evident on the kidney surface for all groups except the group with the probe in contact with the kidney. Glomerular capillary hemorrhage was found by histologic processing in 31.7% +/- 9.8% (mean +/- SD) of glomeruli in the center of the scan plane for 1.7-MPa transabdominal scanning and 1.5% +/- 2.9% of glomeruli in sham samples (P < 0.05). In addition, hematuria was detected after scanning, and tubular obstruction occurred in some nephrons. Renal tissue damage was induced by CEDUS in the porcine model. This result, together with previous studies in rats, support a hypothesis that GCH would occur in humans from similar CEDUS exposure.

It is not known whether perflutren-containing microspheres are excreted in human milk. Based on the rapid clearance of this drug, advise nursing mothers to pump and discard breast milk once after treatment. Because many drugs are excreted in human milk, caution should be exercised when perflutren-containing microsphere products are administered to a nursing mother.

The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including perflutren, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.

Used as a high voltage insulator, refrigerant, plasma processing gas, fire retardant, ultrasound contrast agent, and in repair of retinal detachment; [Merck Index]

High voltage insulating gas; refrigerant when combined with chlorofluoro hydrocarbons; plasma processing gas; fire protection agent

Gaseous insulator, especially for radar waves guides.

MEDICATION

• Machinery and equipment [Ref: http://www.spin2000.net/spinmyphp/]

non-polymer PFAS -> Medicinal Utensils -> Retinal detachment surgery and proliferative vitreoretinopathy

2023: 120,000 lb

Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#8055]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Dithionous acid, sodium salt (1:2). Aggregated National Production Volume: 1 to <10 million lbs.

Octafluoropropane (PFC 218) can be produced by direct, electrochemical, or CoF3-fluorination of commercially available hexafluoropropene.

Preparation: J.H. Simons, US 2456027 (1948 to Minnesota Mining Manufacturing)

Definity (perflutren lipid microsphere) injectable suspension

98% minimum purity. Nonflammable

Computer and Electronic Product Manufacturing

Propane, 1,1,1,2,2,3,3,3-octafluoro-: ACTIVE