(2E)-2-[[(2E)-2-[[[[(5S)-1-[[[(2S,3S,6S,9S,10R)-10-エチル-14-クロロ-2,13-ジヒドロキシ-10-メチル-3-メチルアミノ-6-(1-メチルエテニル)-4,7-ジオキソ-5,8-ジアザ-11-オキサビシクロ[10.3.1]ヘキサデカ-12(16),13,15(1)-トリエン]-9-イル]カルボニル]-2,5-ジヒドロ-1H-ピロール]-5-イル]カルボニル]アミノ]-3-メチル-2-ペンテノイル]アミノ]-2-ブテン二酸

使用Phomopsin A is a an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘ansa’ macrocycle with a tripeptide tail, terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis, and causes lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division. Uniquely, phomopsin A protects tubulin from decay.