基本情報
- CAS
17118-56-8- 標準SMILES
CCCCCCCC/C=C\CCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC- InChIKey
RRVPPYNAZJRZFR-MRCUWXFGSA-N- 分子式
- C42H82NO8P
- 平均分子量
- 760.1 g/mol
- 単同位体質量
- 759.57780557
概要
ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other lipids from cells including those in the arterial wall. LUV are capable of transporting excess cholesterol from the vasculature to the liver for eventual elimination as part of the reverse lipid transport (RLT) pathway. It is believed that the removal of cholesterol by ETC-588 through this pathway may result in the reversal of atherosclerosis. Esperion is currently developing ETC-588 as a treatment for patients with acute coronary syndromes.
名称と識別子
- 優先名称
- 1-Oleoyl-2-palmitoylphosphatidylcholine
- IUPAC
- [2-hexadecanoyloxy-3-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
- 現地名
- 1-オレオイル-2-パルミトイルホスファチジルコリン
- 英語名
- 1-oleoyl-2-palmitoylphosphatidylcholine
- 分子式
- C42H82NO8P
- 分子量
- 760.09
名称と別名
1-Oleoyl-2-palmitoyl lecithin1-Oleoyl-2-palmitoylphosphatidylcholine17118-56-81-Oleyl-2-palmitoyl-sn-glycero-3-phosphocholineRefChem:907766ETC-588Phosphatidyl choline (from egg yolk)8057-53-2[2-hexadecanoyloxy-3-[(Z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium, 4-hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxohexadecyl)oxy)-, inner salt, 4-oxide, (Z)-59491-62-28057-53-2 (from egg yolk)
名称をさらに表示
[O-[1-O-オレオイル-2-O-パルミトイル-L-グリセロ-3-ホスホ]コリン]アニオン[O-(1-O-オレオイル-2-O-パルミトイル-L-グリセロ-3-ホスホ)コリン]アニオン(2-{[(2R)-2-(ヘキサデカノイルオキシ)-3-[(9Z)-オクタデカ-9-エノイルオキシ]プロピル ホスホナト]オキシ}エチル)トリメチルアザニウム1-オレオイル-2-パルミトイルホスファチジルコリン
orb1985435SCHEMBL25949855AKOS040753529DB05456(Z)-3-(oleoyloxy)-2-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate.T34030lecithin, from egg yolk (PC-98T) (for injection)lecithin, from egg yolk (PL-100M) (for injection)
物性
構造計算による物性
- XLogP
- 13.6
- 極性表面積
- 111 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 8
- 回転可能結合数
- 41
- 重原子数
- 52
- 形式電荷
- 0
- 複雑度
- 899
化学と産業
薬理情報
Pharmacodynamics
ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other lipids from cells including those in the arterial wall. LUV are capable of transporting excess cholesterol from the vasculature to the liver for eventual elimination as part of the reverse lipid transport (RLT) pathway.
Mechanism of Action
ETC-588 is a phospholipid bilayer that can sequester cholesterol. Once the HDL particle, which is small enough to enter the arterial wall, pulls the cholesterol out of the plaque, it readily hands the cholesterol over to the LUV. The LUV then transports the cholesterol to the liver for processing.
サプライヤー2 社
HONEST JOY HOLDINGS LIMITED[email protected]
CHEMICAL LAND21[email protected]
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