Trityl chloride (HCID 6456)

名称と識別子

優先名称: Trityl chloride
IUPAC: [chloro(diphenyl)methyl]benzene
現地名: トリチルクロリド
英語名: Triphenylmethyl Chloride
分子式: C19H15Cl
分子量: 278.78

名称と別名

Trityl chloride76-83-5TriphenylchloromethaneCHLOROTRIPHENYLMETHANEMethane, chlorotriphenyl-triphenylmethylchlorideBenzene, 1,1',1''-(chloromethylidyne)tris-DTXSID30525111,1',1''-(Chloromethylidyne)trisbenzene1D9GZ8QQXNNSC-435DTXCID7031084

名称をさらに表示

トリチルクロリドトリフェニルクロロメタントリフェニルメチルクロリドクロロ(トリフェニル)メタントリチルクロライドクロロトリフェニルメタン塩化トリチルクロロメチリジントリスベンゼントリフェニルメチルクロライドトリチルクロライド塩化物塩化トリフェニルメチル(クロロジフェニルメチル)ベンゼン1,1′,1′′-(クロロメチリジン)トリス(ベンゼン)トリチル=クロリドTRT-CLTRITY CHLORIDETRIPHENYLCHLORMETHANEchlorotriphenyl-methanNSC 435

RefChem:575983200-986-4Triphenylmethyl chloride(chloromethanetriyl)tribenzene(chlorodiphenylmethyl)benzeneTrityl Chloride Resin[Chloro(diphenyl)methyl]benzeneC19H15Cl

データベース識別子

CAS: 76-83-5
PubChem CID: 6456
DTXSID: DTXSID3052511
ChEMBL: CHEMBL261393
UNII: 1D9GZ8QQXN
EC Number: 200-986-4
Nikkaji: J62.557D

物性

構造計算による物性

XLogP: 5
極性表面積: 0 Å²
水素結合供与体数: 0
水素結合受容体数: 0
回転可能結合数: 3
重原子数: 20
形式電荷: 0
複雑度: 235

実験および物理化学的性質

Color/FormNEEDLES OR PRISMS FROM BENZENE OR PETROLEUM ETHER

SolubilityINSOL IN WATER, SLIGHTLY SOL IN ALCOHOL, SOL IN ACETONE; VERY SOL IN ETHER, BENZENE, CHLOROFORM, CARBON DISULFIDE, CARBON TETRACHLORIDE

Boiling Point310 °C @ 760 MM HG

Melting Point113-114 °C

Vapor Pressure0.00000387 [mmHg]

Physical DescriptionSolid; [HSDB] Off-white powder with a pungent odor; Hydrolyzed with water; [MSDSonline]

物理化学的性質

融点: 109 · 109-112 °C(lit.)
沸点: 230 · 230-235 °C20 mm Hg(lit.)
比重(密度): 1.1088 · 1.1088 (rough estimate)
屈折率: 1.6281 · 1.6281 (estimate)
闪点: 230 · 230-235°C/20mm
貯蔵温度: 30 °C · Store below +30°C.
溶解性: 0.1 g/mL、透明 · クロロホルム: 0.1 g/mL、透明
外見: 粉末または結晶
色: ホワイトからオフホワイトまたはライトイエローベージュ
水溶解度: 水に溶けません。クロロホルム、ヘキサン、ベンゼン、エーテル、アセトン、テトラヒドロフランに可溶。
BRN: 397363 · 397363
InChI: 1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
InChIKey: JBWKIWSBJXDJDT-UHFFFAOYSA-N
SMILES: ClC(c1ccccc1)(c2ccccc2)c3ccccc3
CAS データベース: 76 · 76-83-5(CAS DataBase Reference)
NISTの化学物質情報: Triphenylmethyl chloride(76-83-5)
EPAの化学物質情報: Chlorotriphenylmethane (76-83-5)

化学的性質 · 1 件

化学的特性Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H314 (77.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (22.6%): Causes skin irritation [Warning Skin corrosion/irritation]；H318 (28.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H335 (40.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H400 (41.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (43.1%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P332+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 137 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 3 件

Chemical: Benzene, 1,1',1''-(chloromethylidyne)tris-

Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18906

Chlorotriphenylmethane: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]

Hazard Classes and CategoriesSkin Corr. 1B (77.4%)；Skin Irrit. 2 (22.6%)；Eye Dam. 1 (28.5%)；STOT SE 3 (40.9%)；Aquatic Acute 1 (41.6%)；Aquatic Chronic 1 (43.1%)

毒性情報

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Non-Human Toxicity Excerpts · 1 件

POTENCY OF TRIPHENYL DERIV OF GROUP IV ELEMENTS IN INHIBITING GROWTH OF 1ST & 4TH INSTAR T CASTANEUM LARVAE WAS MUCH GREATER FOR PH3SNCL & PH3PBCL THAN FOR PH3CCL. IN HIGH CONCN PH3CCL WAS INACTIVE IN INHIBITING IN VITRO INVERTASE, AMYLASE & PROTEASE ACTIVITIES.

法規制情報

Regulatory Information · 3 件

Chemical: Benzene, 1,1',1''-(chloromethylidyne)tris-

Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18906

Chlorotriphenylmethane: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F: 10-19-21
wgk: 3
tsca: TSCA listed
rtecs: PA6450000
ridadr: UN 3261 8/PG 3
毒性: LD50 orally in Rabbit: > 5000 mg/kg
hs_code: 29036990
risk_code: 34-50/53-14-36/37
化審法: (9)-897
hazard_code: C,N
hazard_note: Irritant
safety_code: 26-36/37/39-45-61-27
hazard_class: 8
packing_group: III
Hazard Classifications: Skin Corr. 1B
ストレージクラス: 8A - Combustible corrosive hazardous materials
有毒物質データの: 76-83-5(Hazardous Substances Data)

化学と産業

用途と製造

General Manufacturing Information · 2 件

Benzene, 1,1',1''-(chloromethylidyne)tris-: ACTIVE

TRIARYL CHLOROALKANE IMPROVED ADHESION OF FAST-SETTING POLYURETHANE PREPOLYMER TO TISSUE.

応用分野 · 3 件

解説トリフェニルメチルクロリド，融点112～113 ℃，沸点310 ℃．エーテル，クロロホルム，ベンゼンに可溶．テトラヒドロフラン中で等モル量のリチウムナフタレニドを作用させるとトリフェニルメチルラジカルを生成し，二量化する．ピリジン中，第一級，第二級アルコールやフェノールと反応して相当するエーテルを与え，ヒドロキシ基の保護剤として用いられる．アルドヘキソースとは第一級ヒドロキシ基のみ，またシステインとはアミノ基ではなくチオール基と反応するという選択性を示す．森北出版「化学辞典（第2版）

用途確認(アルコール)。

使用Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.

調製方法 · 1 件

純化方法Crystallise trityl chloride from iso-octane. Also crystallise it from 5 parts of pet ether (b 90-100o) and 1 part of acetyl chloride using 1.8g of solvent per g of chloride. Dry it in a desiccator over soda lime and paraffin wax. [Bachman Org Synth Coll Vol III 841 1955, Thomas & Rochow J Am Chem Soc 79 1843 1957, Moisel et al. J Am Chem Soc 108 4706 1986, Beilstein 5 H 750, 5 I 346, 5 II 615, 5 III 2315, 5 IV 2497.] It is moisture sensitive and LACHRYMATORY,