基本情報
- CAS
7081-53-0- 標準SMILES
CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O.Cl.O- InChIKey
ZOMBFZRWMLIDPX-UHFFFAOYSA-N- 分子式
- C24H33ClN2O3
- 平均分子量
- 433 g/mol
- 単同位体質量
- 432.2179706
概要
Doxapram Hydrochloride is a peripheral and central respiratory stimulant with a brief duration of action. Doxapram hydrochloride stimulates respiration by an action on chemoreceptors in the carotid arteries and, at increased dosage, stimulates central respiratory centers in the medulla as well as other parts of the brain and spinal cord. This results in an increased tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may also improve cardiac output probably due to an increased release of catecholamines. This respiratory stimulant is used in postanesthesia respiratory depression.
名称と識別子
- 優先名称
- Doxapram Hydrochloride
- IUPAC
- 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrate;hydrochloride
- 現地名
- ドキサプラム塩酸塩水和物
- 英語名
- Doxapram hydrochloride monohydrate
- 分子式
- C24H30N2O2.ClH.H2O
- 分子量
- 432.99
名称と別名
Doxapram hydrochloride monohydrateDoxapram HCLStimulexinP5RU6UOQ5YAHR-619NSC-170958NSC-760347DTXCID9027815CHEBI:31520NSC170958RefChem:565601-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate
名称をさらに表示
ドキサプラム塩酸塩水和物ドキサプラム塩酸塩一水和物ドキサプラム塩酸塩水和物 (JP17)1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydrDoxapraM HCL APIDoxapram HydrochorideDoxapram hydrochloride CRSDoxapraM Hydrochloride, USPdoxapramhydrochloridehydrateDopram hydrochloride hydrate
Doxapram HydrochlorideDTXSID90478377081-53-0Doxapram hydrochloride hydrate15083-72-4DopramDoxapraM interMediateMFCD09954698
データベース識別子
- CAS
7081-53-0
物性
構造計算による物性
- 極性表面積
- 33.8 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 6
- 重原子数
- 30
- 形式電荷
- 0
- 複雑度
- 487
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
物理化学的性質
- 融点
- 217 · 217-219°
- 貯蔵温度
- Sealed in dry,Room Temperature
- 溶解性
- 水、アルコール、塩化メチレンに溶ける。
- 外見
- Solid
- 色
- White to off-white
- 主な用途
- 医薬品（低分子化合物）
- InChI
- InChI=1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2
- InChIKey
- ZOMBFZRWMLIDPX-UHFFFAOYSA-N
- SMILES
- C1(=O)N(CC)CC(CCN2CCOCC2)C1(C1C=CC=CC=1)C1C=CC=CC=1.Cl.O
化学的性質
化学的特性White or almost white, crystalline powder.
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H302 (96.4%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 55 reports by companies from 2 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory InformationDoxapram hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (96.4%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Doxapram hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
安全データ
- wgk
- WGK 3
- ridadr
- UN 2811 6.1 / PGIII
- 毒性
- LD50 orally in rats: 261 mg/kg (Goldenthal)
- hs_code
- 2934990002
- Hazard Classifications
- Acute Tox. 3 Oral
- ストレージクラス
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
化学と産業
薬理情報
FDA Pharmacological Classification
DOXAPRAM HYDROCHLORIDE
Increased Medullary Respiratory Drive [PE]; Respiratory Stimulant [EPC]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs used for their effects on the respiratory system.
応用分野
説明Doxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
使用antibacterial
一般的な説明Doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate (Dopram), has an obscuremolecular mechanism of action. Overall, it stimulatesrespiration by action on peripheral carotid chemoreceptors.It has use as a respiratory stimulant postanesthetically, afterCNS depressant drug overdose, in chronic obstructive pulmonarydiseases, and in the apneas. Dopram is administeredexclusively by intravenous injection. Because of the benzylalcohol content of the injectable formulation, Dopram mustnever be given to neonates.
上流・下流製品情報
上流原料
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