CAS 859-18-7 Lincomycin Hydrochloride Anhydrous (HCID 64710)

概要

Lincomycin Hydrochloride is the hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete Streptomyces lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

名称と識別子

優先名称: Lincomycin Hydrochloride Anhydrous
IUPAC: (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
現地名: リンコシン塩酸塩
英語名: Lincomycin hydrochloride
分子式: C18H35ClN2O6S
分子量: 443

名称と別名

Lincomycin hydrochloride859-18-7LINCOMYCIN HCLLincomix 20Lincomycin hydrochloride anhydrousLincomixDTXSID7047803GCW8Y9936LLincomycin solubleLincolnensin hydrochlorideDTXCID9027780Lincomycin hydrochloride anhdrous

名称をさらに表示

メチル6-[[[(2S,4R)-1-メチル-4-プロピル-2-ピロリジニル]カルボニル]アミノ]-6,8-ジデオキシ-1-チオ-D-erythro-α-D-galacto-オクトピラノシド·塩酸塩リンタマイシン塩酸リンコマイシンルニアマイシンリンコシン塩酸塩リンコメイスリンコマイシン塩酸塩リズピオンペランコシンリンコマイシン塩酸塩標準品リンコマイシン塩酸塩一水和物標準品リンコマイシン塩酸塩メチル6-[[[(2S,4R)-1-メチル-4-プロピル-2-ピロリジニル]カルボニル]アミノ]-6,8-ジデオキシ-1-チオ-D-erythro-α-D-galacto-オクトピラノシド・塩酸塩Lincomycin hydrochloride monohydrateLincomycin HCILincorexLintamycinMETHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE(2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochlorideLizpionU-10149ALincogap

D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, monohydrochloride, (2S-trans)-NSC70731NSC-70731NSC-757092Linco SolubleLinxMed-SPLincomix 50LincoBac 300

データベース識別子

CAS: 859-18-7
PubChem CID: 64710
DTXSID: DTXSID7047803
ChEMBL: CHEMBL3989551
UNII: GCW8Y9936L
EC Number: 212-726-7

物性

構造計算による物性

極性表面積: 148 Å²
水素結合供与体数: 6
水素結合受容体数: 8
回転可能結合数: 7
重原子数: 28
形式電荷: 0
複雑度: 498

実験および物理化学的性質

Human Drugs · 2 件

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Lincomycin Hydrochloride) -> FDA Greenbook

Collision Cross Section199.1 Å² [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

物理化学的性質

融点: 156 · 156-158C
貯蔵温度: 2 · 2-8°C
溶解性: 2 O: · H2O: 50 mg/mL 無色透明
外見: 個体
色: 黄色かぶりのある白から白
水溶解度: 水に溶ける。
BRN: 4171650 · 4171650
安定性: 吸湿性
InChIKey: POUMFISTNHIPTI-BOMBIWCESA-N
SMILES: [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|
EPAの化学物質情報: 6 · D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)

化学的性質

化学的特性Crystalline

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H315 (62.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 82 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Status: Active Update: 17-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33514

lincomycin hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-: Environment tier I assessment

Hazard Classes and CategoriesSkin Irrit. 2 (62.2%)

毒性情報

Drug Induced Liver Injury · 6 件

Drug Induced Liver Injury Rank (DILIrank 2.0)

Lincomycin hydrochloride

Ambiguous-DILI-concern

3

Warnings & precautions

DOI:10.1016/j.drudis.2016.02.015

安全データ

F: 10
wgk: 2
rtecs: RH6315000
hs_code: 29419000
risk_code: 36/37/38-20/21/22
hazard_code: Xi,Xn
safety_code: 26-36
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Substances that inhibit the growth or reproduction of BACTERIA.

用途と製造

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

応用分野 · 2 件

使用Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

一般的な説明Chemical structure: macrolide

上流・下流製品情報

上流原料

リンダン

下流製品

りん酸クリンダマイシンリンコマイシン

サプライヤー100 社

北京华美互利生物化工010-56205725 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]

广州隽唐科技有限公司020-36607679 13502246435 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

化合物ノート

読み込み中…

リンコシン塩酸塩

基本情報

概要