ピマリシン

解説ピマリシン,白色の結晶性粉末．分解点300 ℃．[α]20D＋235～255°(水)．λmax 290，303，318 nm(メタノール)．メタノールに微溶，水に不溶，氷酢酸に易溶．角膜真菌症治療薬として使用される．LD50 3000 mg/kg(ラット，経口)．[CAS 7681-93-8]森北出版「化学辞典（第2版）

用途ナタマイシン（natamycin, INN）は、通常土壌中に見いだされる微生物Streptomyces natalensisによる発酵の際に生産される天然の抗真菌薬である。ナタマイシンは、マクロリドポリエン系抗真菌薬に分類され、薬としては真菌性角膜炎 (keratitis) の治療に使用される。ナタマイシンは特に、アスペルギルス属 (Aspergillus) およびフザリウム属 (Fusarium) の角膜への感染に対して有効である。

説明Natamycin is a naturally occurring macrolide polyene antifungal agent produced during fermentation by the bacterium S. natalensis, commonly found in soil. With minimal inhibitory concentrations ranging from 4-64 μM, natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. Natamycin blocks fungal growth by binding specifically to ergosterol with an apparent affinity of ~100 μM, but it does not permeabilize cell membranes as other polyene antibiotics are known to do. Natamycin is also used in the food industry as a preservative.

使用Natamycin (l), from Streptomyces nataIensis and Streptomyces chat tanoogensis, is used for the control of diseases of bulbs.

一般的な説明Natamycin (pimaricin; Natacyn) is a polyene antibiotic obtainedfrom cultures of Streptomyces natalensis.The natamycin structure consists of a 26-membered lactonering containing a tetraene chromophore, an α,β-unsaturatedlactone carbonyl group, three hydroxyl groups, a carboxyl group, a trans epoxide, and a glycosidically joined mycosamine.Like the other polyene antibiotics, natamycin isamphoteric.The smaller polyenes are fungistatic and fungicidal within thesame concentration range.Natamycin possesses in vitro activity against severalyeasts and filamentous fungi, including Candida,Aspergillus, Cephalosporium, Penicillium, and Fusariumspp. The drug is supplied as a 5% ophthalmic suspension intendedfor the treatment of fungal conjunctivitis, blepharitis,and keratitis.