基本情報
- CAS
97635-31-9- 標準SMILES
O=C([O-])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO.[Ca+2]- InChIKey
YPCRNBPOUVJVMU-LCGAVOCYSA-L- 分子式
- C18H32CaO19
- 平均分子量
- 592.5 g/mol
- 単同位体質量
- 592.1163696
概要
Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
名称と識別子
- 優先名称
- (4-O-beta-D-Galactopyranosyl-D-gluconato-O1)(D-gluconato-O1)calcium
- IUPAC
- calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate
名称と別名
97635-31-9UNII-93H20IU3DN(4-O-beta-D-Galactopyranosyl-D-gluconato-O1)(D-gluconato-O1)calciumEINECS 307-393-0EBC-27362DB13142calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate;(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoateCalcium, (4-O-beta-D-galactopyranosyl-D-gluconato-O1)(D-gluconato-O1)-
データベース識別子
- CAS
97635-31-9- PubChem CID
- 64776
- EC Number
- 307-393-0
物性
構造計算による物性
- 極性表面積
- 362 Ų
- 水素結合供与体数
- 13
- 水素結合受容体数
- 19
- 回転可能結合数
- 15
- 重原子数
- 38
- 形式電荷
- 0
- 複雑度
- 686
化学と産業
薬理情報
Protein Binding~40%, primarily to albumin
Mechanism of Action
Essential for nervous, muscular, and skeletal systems. Maintain cell membrane and capillary permeability. Act as an activator in the transmission of nerve impulses and contraction of cardiac, skeletal, and smooth muscle. Essential for bone formation and blood coagulation.
Absorption, Distribution and Excretion
Minimal unless chronic, high doses; absorption predominantly in the duodenum and dependent on calcitriol and vitamin D; mean absorption of calcium intake varies with age (infants 60%, prepubertal children 28%, pubertal children 34%, adults 25%); during pregnancy, calcium absorption doubles; calcium is absorbed in soluble, ionized form; solubility of calcium is increased in an acid environment (IOM 2011); decreased absorption occurs in patients with achlorhydria, renal osteodystrophy, steatorrhea, or uremia
Primarily feces (75%; as unabsorbed calcium); urine (22%)
Primarily in bones, teeth
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