ロイコトリエンA4-メチルエステル溶液 (100ΜG/ML ヘキサン/1%トリエチルアミン)
ロイコトリエンA4-メチルエステル溶液 (100ΜG/ML ヘキサン/1%トリエチルアミン) · (-)-leukotriene A4 · LEUKOTRIENE A4 METHYL ESTER · PWXYNAKNLZUYAL-WAQVJNLQSA-N · (-)-Leukotriene A4 methyl ester · LTA4 (Leukotriene A4 methyl ester) · 5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER · LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE)
識別子と物理属性
| CAS No. | 73466-12-3 |
|---|---|
| 分子式 | C21H32O3 |
| 平均分子量 | 332.5 g/mol |
| 単同位体質量 | 332.23514488 g/mol |
| SMILES | CCCCC/C=C\C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(=O)OC |
| InChIKey | WTKAVFHPLJFCMZ-NIBLXIPLSA-N |
| PubChem CID | 6478221 |
| EC No. | 633-240-5 |
| DTXSID | DTXSID10424293 |
| 現地名 | ロイコトリエンA4-メチルエステル溶液 (100ΜG/ML ヘキサン/1%トリエチルアミン) |
化学・物理的性質
| XLogP | 5.6 |
|---|---|
| 極性表面積 | 38.8 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 3 |
| 回転可能結合数 | 14 |
| 重原子数 | 24 |
| 形式電荷 | 0 |
| 複雑度 | 446 |
| 沸点 | 442.453±25.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 0.998±0.06 g/cm3(Temp: 25 °CPress: 760 Torr)(predicted) |
| 貯蔵条件 | −20°C |
| 溶解度 | Acetone: >50 mg/mlDMF: >50 mg/mlDMSO: >50 mg/mlEthanol: >50 mg/mlPBS pH 7.2: insoluble and unstable. |
| 外観・状態 | トリエチルアミン:ヘキサン溶液 |
安全性と法規制
| GHS 分類 | DangerH225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Flam. Liq. 2 (100%) |
| 水環境危害等級（WGK） | 2 |
| 輸送番号（UN） | UN 1208 3/PG 2 |
| 危険文句（R） | 11-36/37/38-48/20-51/53-62-65-67 |
| 危険表示 | F,Xn,N |
| 安全措置（S） | 9-16-29-33-36/37-61-62 |
| 危険等級 | Aquatic Chronic 2Asp. Tox. 1Eye Irrit. 2Flam. Liq. 2Repr. 2Skin Irrit. 2STOT RE 1 InhalationSTOT SE 3 |
| 貯蔵分類 | 3 - Flammable liquids |
用途
説明
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
使用
LTA4 (Leukotriene A4 methyl ester) is an unstable intermediate in the biosynthesis of LTB4 and LTC4.