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EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=77-65-6]

...PT /DESCRIBED/ WHO HAD REVERSIBLE REDN OF VISION WITH CENTRAL SCOTOMA & TEMPORAL PALLOR OF OPTIC NERVEHEAD AFTER YR LONG DAILY USE... CASE /ALSO REPORTED/ OF RETROBULBAR NEURITIS WITH HYPEREMIA OF OPTIC NERVEHEAD FROM CHRONIC POISONING, WITH IMPROVEMENT AFTER DRUG WAS STOPPED.

IN INTOXICATION, SHOCK-LUNG & INTRAVASCULAR COAGULATION DEFECT MAY OCCUR.

A CASE OF INTOXICATION WITH 8 G OF CARBROMAL RESULTING IN ACUTE RENAL FAILURE & BILATERAL DEEP VEIN THROMBOSES IS DESCRIBED.

CASE OF CARBROMAL-INDUCED PURPURA IS DESCRIBED & TYPICAL CLINICAL FEATURES ARE PRESENTED.

For more Human Toxicity Excerpts (Complete) data for CARBROMAL (6 total), please visit the HSDB record page.

Carbromal

TR-173: Bioassay of Carbromal for Possible Carcinogenicity (CASRN 77-65-6) (1979 )

08/31/78

No Evidence

No Evidence

No Evidence

CARBROMAL ADDED TO RAT OR GUINEA PIG ATRIAL PREPN OR GUINEA PIG LANGENDORFF PREPARATIONS HAD NEGATIVE INOTROPIC, CHRONOTROPIC, DROMOTROPIC, & BATHMOTROPIC EFFECTS.

A STUDY OF BLOOD GASES AND LUNG MORPHOLOGY IN BROMOCARBAMIDE INTOXICATION.

... Under the conditions of this bioassay, dietary admin of carbromal was not carcinogenic in Fischer 344 rats or B6C3F1 mice. ... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

CARDIODEPRESSIVE ACTIONS MAY BE IMPORTANT FOR THE COURSE & ENDING OF SEVERE CARBROMAL INTOXICATIONS.

EFFICIENCY OF DIFFERENT DETOXICATION METHODS FOR CARBROMAL INTOXICATIONS EVALUATED ON BASTARD DOGS. HEMOPERFUSION IS MOST EFFECTIVE IN ELIMINATION OF CARBROMAL & HEMODIALYSIS FOR REMOVAL OF BROMIDE. HEMOFILTRATION WAS LEAST EFFECTIVE FOR BOTH & SHOULD NOT BE USED.

EXPTL DOPAMINE ACCELERATED ELIM OF CARBROMAL 3-FOLD OVER THAT OF FORCED DIURESIS BY INCR URINE FLOW & GLOMERULAR FILTRATION RATE. METHOD RECOMMENDED OVER FORCED DIURESIS SINCE HEMODYNAMICS WAS MORE STABLE & ELECTROLYTE BALANCE LESS DISTURBED.

SERUM LEVELS OF CARBROMAL WERE 7-17 TIMES HIGHER IN POISONED PT THAN THOSE AFTER THERAPEUTIC DOSES. HEMODIALYSIS CAN BE USED TO REMOVE CARBROMAL & ITS METABOLITE, ETHYLBUTYLUREA.

A bioassay for the possible carcinogenicity of carbromal was conducted using Fischer 344 rats and B6C3F1 mice. Carbromal was admin in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species with the exception of 49 low dose male mice and high dose female mice. Twenty animals of each sex and species were placed on test as controls. The high and low dietary concn of carbromal were, respectively, 2,500 and 1,250 ppm for rats and 2,500 and 1,250 ppm for mice. The cmpd was admin for 103 wk to rats and 78 wk for mice. The period of cmpd admin was followed by an observation period of 1 wk for rats and 26 wk for mice. ... Under the conditions of this bioassay, dietary admin of carbromal was not carcinogenic in Fischer 344 rats or B6C3F1 mice. ... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.