基本情報
- CAS
593-84-0- 標準SMILES
N#CS.N=C(N)N- InChIKey
ZJYYHGLJYGJLLN-UHFFFAOYSA-N- 分子式
- CH5N3.CHNS
- 平均分子量
- 118.16 g/mol
- 単同位体質量
- 118.03131738
概要
a powerful chaotropic agent
名称と識別子
- 優先名称
- Guanidine thiocyanate
- IUPAC
- guanidine;thiocyanic acid
- 現地名
- グアニジンチオシアナート
- 英語名
- Guanidine thiocyanate
- 分子式
- CH5N3.CHNS
- 分子量
- 118.16
名称と別名
Guanidine thiocyanate593-84-0Guanidinium thiocyanateGuanidine, monothiocyanateBUFFER AVLGCA2EU297UGuSCNNSC-2119DTXSID6060478RefChem:144652DTXCID1042601209-812-1
名称をさらに表示
グアニジンチオシアナートグアニジンイソチオシアナートチオシアン酸·グアニジングアニジン·チオシアン酸塩グアニジン·チオシアン酸グアニジンチオシアネ-トグアニジンチオシアン酸塩グアニジンチオシアナート [生化学用]チオシアン酸とグアニジンの塩（1：1）チオシアン酸グアニジンチオシアン酸グアニジン 溶液グアニジン・チオシアン酸グアニジン・チオシアン酸塩チオシアン酸・グアニジンロダングアニジンGUANIDINIUM ISOTHIOCYANATEGdmSCNabs9138usafek-705GUANIDIN THIOCYGTC,guanidineth
guanidine isothiocyanateguanidine;thiocyanic acidGuanidinium rhodanideMFCD00013027USAF EK-705M01833GTCguanidinethiocyanate
データベース識別子
- CAS
593-84-0- PubChem CID
- 65046
- DTXSID
DTXSID6060478- UNII
- GCA2EU297U
- EC Number
- 209-812-1
物性
構造計算による物性
- 極性表面積
- 101 Ų
- 水素結合供与体数
- 4
- 水素結合受容体数
- 3
- 回転可能結合数
- 0
- 重原子数
- 7
- 形式電荷
- 0
- 複雑度
- 57.6
実験および物理化学的性質
Chemical ClassesOther Uses -> Biochemical Research
Physical Description
Liquid; Dry Powder
White crystalline solid; Hygroscopic; [Sigma-Aldrich MSDS]
物理化学的性質
- 融点
- 120 · 120-122 °C(lit.)
- 比重(密度)
- 1.103 g/mL · 1.103 g/mL at 20 °C
- 蒸気圧
- 0 Pa · 0Pa at 20℃
- 屈折率
- 20 · n20/D 1.482
- 貯蔵温度
- 20 · 20-25°C
- 溶解性
- 2 O: · H2O: 6M at20℃、透明、無色
- 外見
- 結晶または結晶性粉末
- 酸解離定数(Pka)
- 12.5 · 12.5[at 20 ℃]
- 色
- 白または無色
- 比重
- 1.152 · 1.152
- 臭い (Odor)
- 無臭
- PH
- 4.8 · 4.8-6.0 (1420g/l, H2O, 20℃)(saturated solution)
- 由来生物
- synthetic (organic)
- 水溶解度
- 水およびエタノールに可溶
- BRN
- 3563461 · 3563461
- 安定性
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 0.2% (1 of 404) of reports.
Danger
H302+H312+H332 (45.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 404 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Chemical: Thiocyanic acid, compound with guanidine (1:1)
Thiocyanic acid, compd. with guanidine (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiocyanic acid, compd. with guanidine (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Guanidinium thiocyanate (EC: 209-812-1)
Guanidinium thiocyanate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryIntraperitoneal LD50 (mouse) = 300 mg/kg; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See Guanidine. See Sodium thiocyanate.
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
安全と保護具
Protective Action Criteria (PAC)
化学と産業
薬理情報
MeSH Pharmacological Classification
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
用途と製造
UsesA powerful chaotropic agent. [ChemIDplus] Used for RNA isolation and can solubilize proteins; [Santa Cruz Biotechnology]
U.S. Production2023: <50,000 lb
Consumer UsesLaboratory chemicals
Industry UsesLaboratory chemicals
General Manufacturing Information
Other (requires additional information)
Thiocyanic acid, compd. with guanidine (1:1): ACTIVE
応用分野
用途蛋白の変性剤。
使用Guanidine thiocyanate is a useful tool for RNA isolation and protein solubilization. It is involved in the quantification of mRNA from hepatocytes. It acts as a medium for blood smaple lystae in order to maintain the integrity of nucleic acid. It is a chaotropic agent, mainly involved in the extraction of DNA and RNA. It is utilized to deactivate the influenza virus.
一般的な説明Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers.
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