L-ノルバリン
L-ノルバリン · [S,(+)]-2-アミノ吉草酸 · (+)-2-アミノ吉草酸 · (+)-L-ノルバリン · (2S)-2-アミノペンタン酸 · (S)-2-アミノペンタン酸 · ノルバリン · (S)-2-アミノ吉草酸
識別子と物理属性
| CAS No. | 6600-40-4 |
|---|---|
| 分子式 | C5H11NO2 |
| 平均分子量 | 117.15 g/mol |
| 単同位体質量 | 117.07897859 g/mol |
| SMILES | CCC[C@H](N)C(=O)O |
| InChIKey | SNDPXSYFESPGGJ-BYPYZUCNSA-N |
| PubChem CID | 65098 |
| ChEMBL | CHEMBL55612 |
| ChEBI | CHEBI:18314 |
| EC No. | 229-543-3 |
| DTXSID | DTXSID701018015 |
| 現地名 | L-ノルバリン |
化学・物理的性質
| XLogP | -2.1 |
|---|---|
| 極性表面積 | 63.3 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 3 |
| 回転可能結合数 | 3 |
| 重原子数 | 8 |
| 形式電荷 | 0 |
| 複雑度 | 82.5 |
| 医薬品 | Pharmaceuticals -> Listed in ZINC15 |
| 脂質 | Fatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Amino fatty acids [FA0110] |
| 化粧品 | Antistatic |
| Collision Cross Section | 142 Ų [M-H]- [CCS Type: DTMethod: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]133 Ų [M+Na]+ |
| 融点 | >300 °C(lit.) |
| 比旋光度 | 24.5 º (c=10, 6 N HCl) |
| 沸点 | 222.9±23.0 °C(Predicted) |
| 密度 | 1.2000 (estimate) |
| 屈折率 | 25 ° (C=10, 6mol/L HCl) |
| 貯蔵条件 | Store below +30°C. |
| 溶解度 | 48.7g/リットル10.5g/100mL(18℃) |
| 外観・状態 | 微結晶性粉末 |
| pKa（酸解離定数） | 2.32(at 25℃) |
| 色 | 白い |
| Merck | 14,6716 |
| BRN | 1721162 |
| 主な用途 | 検査 |
| 化粧品成分の機能 | 帯電防止 |
| InChI | 1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 |
| InChIKey | SNDPXSYFESPGGJ-BYPYZUCNSA-N |
| SMILES | CCC[C@H](N)C(O)=O |
| CAS データベース | 6600-40-4(CAS DataBase Reference) |
| NISTの化学物質情報 | L-Norvaline(6600-40-4) |
化学的特性
white to light yellow crystal powder
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 75% (6 of 8) of all reports.WarningH315 (25%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Status: Active Update: 22-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23649 |
| Hazard Classes and Categories | Skin Irrit. 2 (25%) |
| 水環境危害等級（WGK） | 3 |
| 税関コード | 29224995 |
| 危険文句（R） | 20/21/22-36/37/38 |
| 化審法 | (2)-3889 |
| 危険表示 | C,Xn |
| 安全措置（S） | 24/25-37/39-26 |
| 貯蔵分類 | 11 - Combustible Solids |
用途
解説
2-アミノ吉草酸．非天然系のアミノ酸，CH3(CH2)2CH(NH2)COOH．タンパク質構成アミノ酸として知られているバリンの異性体．バリンが末端にメチル側鎖をもつのに対し，ノルバリンは直鎖(ノルマル)化合物であるという意味で，ノルを冠して命名されたものであり，同族体の意味のノルではない．
説明
L-Norvaline, an amino acid nutritional supplements, is a nonessential amino acid that’s typically found in protein-rich foods, such as meat and eggs. And, it can also be made by the body from valine during normal metabolism. L-norvaline is frequently consumed by athletes as part of their workout supplement program. It is usually used for pre-workout drinks to boost energy and support post-workout recovery. During workouts, L-norvaline improves muscle tissue strength and endurance by providing massive amounts of oxygen and nutrients.
使用
L-Norvaline is a protein amino acid used as a skin-conditioning and anti-static agent. It is also used in method for reducing misincorporation of non-canonical branched-chain Amino Acids into recombinant proteins.
製法・合成法
純化方法
Crystallise norvaline from aqueous EtOH or water. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2390-2399 1961, Beilstein 4 III 1331-1333, 4 IV 128, 2629.]