化工社化工社 化学情報印刷レポート · 研究参考用
シクロヘキサノンパ-オキサイド
シクロヘキサノンペルオキシド · シクロヘキサノンパーオキサイド · シクロヘキサノンパ-オキサイド · Cyclohexanone peroxi · CYCLOHEXANONE PEROXIDE · Cyclohexanone peroxide solution · 1,1'-Peroxybis(1-hydroperoxycyclohexane) · 1-HYDROPEROXYCYCLOHEXYL-1-HYDROXY CYCLOHEXYL PEROXIDE
識別子と物理属性
| CAS No. | 12262-58-7 |
|---|---|
| 分子式 | C12H22O5 |
| 平均分子量 | 246.3 g/mol |
| 単同位体質量 | 246.1467238 g/mol |
| SMILES | OOC1(OOC2(O)CCCCC2)CCCCC1 |
| InChIKey | UICXTANXZJJIBC-UHFFFAOYSA-N |
| PubChem CID | 6521 |
| EC No. | 201-091-1 |
| DTXSID | DTXSID9058812 |
| 現地名 | シクロヘキサノンパ-オキサイド |
化学・物理的性質
| XLogP | 2.3 |
|---|---|
| 極性表面積 | 68.2 |
| 水素結合供与体数 | 2 |
| 水素結合受容体数 | 5 |
| 回転可能結合数 | 4 |
| 重原子数 | 17 |
| 形式電荷 | 0 |
| 複雑度 | 231 |
| 物質分類 | Other Classes -> Peroxides, Organic |
| 密度 | 1.05 at 68 °F (USCG, 1999) - Denser than waterwill sink1.15[at 20℃] |
| Color/Form | Grayish paste |
| 溶解度 | OFF-WHITE THICK PASTEINSOL IN WATERSOL IN COMMON ORG SOLVENTS /PASTE WITH DIBUTYL PHTHALATE/Insoluble in watersoluble in most organic solvents9.3g/L at 25℃ |
| 引火点 | 315 °F Combustible solution) (dibutyl phthalate) (USCG, 1999) |
| 融点 | 76-77 °C65-70 °C |
| 蒸気圧 | 0.00000071 [mmHg]2.16Pa at 25℃ |
| Physical Description | Cyclohexanone peroxide, not more than 72% in solution is a white solid dissolved in some unkown organic solvent. Responders should try to identify the solvent being used. Solvent is added to lessen explosion hazard.1-hydroxy-1'-hydroperoxy dicyclohexyl peroxide is an odorless thick white liquid. Sinks in water. (USCG, 1999)Odorless thick white liquid or paste[CAMEO] Moist white solid[MSDSonline] |
| 自然発火温度 | 757 °F (USCG, 1999) |
| LogP（分配係数） | 1.2 at 29℃ |
| EPAの化学物質情報 | Cyclohexanone, peroxide (12262-58-7) |
安全性と法規制
| GHS 分類 | DangerH240: Heating may cause an explosion [Danger Self-reactive substances and mixturesOrganic peroxides]P210, P234, P235, P240, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P372+P380+P373, P403, P405, P410, P411, P420, and P501 (click each P-code to see the statement) |
|---|---|
| 規制情報 | Chemical: Cyclohexanol, 1-[(1-hydroperoxycyclohexyl)dioxy]-Chemical: Cyclohexanone, peroxideCyclohexanone, peroxide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cyclohexanone, peroxide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Cyclohexanone, peroxide (EC: 235-527-7)Cyclohexanone peroxide, 30-60%, 30-60% dibutyl phthalate, 10-30% ethyl acetate: Does not have an individual approval but may be used under an appropriate group standardCyclohexanone peroxide, >25% in a non hazardous diluent: Does not have an individual approval but may be used under an appropriate group standard |
| 輸送ラベル（DOT） | Organic Peroxide |
| 火災危険 | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Behavior in Fire: May explode (USCG, 1999) |
| 火災の可能性 | DANGEROUS /FIRE HAZARD/ BY CHEM REACTION WITH REDUCING AGENTS OR EXPOSURE TO HEAT. THEY ARE POWERFUL OXIDIZERS. /PEROXIDES, ORG/ALTHOUGH FLASHPOINTS OF MOST ORG PEROXIDES ARE NOT EXCEPTIONALLY LOW, WHEN IGNITED THEY BURN MORE FURIOUSLY THAN CORRESPONDING FLAMMABLE LIQ NOT CONTAINING THE PEROXY LINKAGE. ORG PEROXIDES CONTAIN SUFFICIENT AVAILABLE OXYGEN TO SUPPORT THEIR OWN COMBUSTION IN...ABSENCE OF ATMOSPHERIC OXYGEN. /PEROXIDES, ORG/ |
| 健康有害性 | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Irritates eyes and skin on contact. Ingestion causes irritation of mouth and stomach. (USCG, 1999) |
| 有害性の概要 | Water is added to paste to decrease explosion hazard[CAMEO] A skin sensitizerBlistering of the skin from prolonged contactMethemoglobinemia in high-dose animal feeding studies[HSDB] CorrosiveInhalation of high concentration may be fatal as the result of acute laryngeal/bronchial injury and chemical pneumonitis[MSDSonline] |
| 反応性グループ | Alcohols and Polyols |
| Reactivity Alerts | Explosive |
| Reactivity Profile | Peroxides, such as CYCLOHEXANONE PEROXIDE, are good oxidizing agents. Organic compounds can ignite on contact with concentrated peroxides. Strongly reduced material such as sulfides, nitrides, and hydrides may react explosively with peroxides. There are few chemical classes that do not at least produce heat when mixed with peroxides. Many produce explosions or generate gases (toxic and nontoxic). Generally, dilute solutions of peroxides (<70%) are safe, but the presence of a catalyst (often a transition metal such as cobalt, iron, manganese, nickel, or vanadium) as an impurity may even then cause rapid decomposition, a buildup of heat, and even an explosion. Solutions of peroxides often become explosive when evaporated to dryness or near-dryness. Danger of explosion when dry. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated.Peroxides, such as 1-HYDROXY-1'-HYDROPEROXY DICYCLOHEXYL PEROXIDE, are good oxidizing agents. Organic compounds can ignite on contact with concentrated peroxides. Strongly reduced material such as sulfides, nitrides, and hydrides may react explosively with peroxides. There are few chemical classes that do not at least produce heat when mixed with peroxides. Many produce explosions or generate gases (toxic and nontoxic). Generally, dilute solutions of peroxides (<70%) are safe, but the presence of a catalyst (often a transition metal such as cobalt, iron, manganese, nickel, or vanadium) as an impurity may even then cause rapid decomposition, a buildup of heat, and even an explosion. Solutions of peroxides often become explosive when evaporated to dryness or near-dryness. May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Behavior in Fire: May explode (USCG, 1999). |
| DOT Emergency Guidelines | /GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Fire or Explosion: May explode from heat or contamination. May ignite combustibles (wood, paper, oil, clothing, etc.). May be ignited by heat, sparks or flames. May burn rapidly with flare-burning effect. Containers may explode when heated. Runoff may create fire or explosion hazard. /Organic peroxide type D, liquidOrganic peroxide type D, solid//GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Health: Fire may produce irritating, corrosive and/or toxic gases. Ingestion or contact (skin, eyes) with substance may cause severe injury or burns. Runoff from fire control or dilution water may cause pollution. /Organic peroxide type D, liquid/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Organic peroxide type D, liquid/GUIDE 145: ORGANIC PEROXIDES (HEAT AND CONTAMINATION SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection. /Organic peroxide type D, liquidFor more DOT Emergency Guidelines (Complete) data for CYCLOHEXANONE PEROXIDE (16 total), please visit the HSDB record page. |
| Air and Water Reactions | Combines with water to form grayish paste. Insoluble in water.No rapid reaction with air. No rapid reaction with water. |
| Hazard Classes and Categories | Org. Perox. A (70.9%)Org. Perox. A (70.4%)Organic peroxide - type AOrganic peroxide - type C |
| 消火 | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Fire Extinguishing Agents: Water, foam, dry chemical, carbon dioxide (USCG, 1999) |
| 応急処置 | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:EYES: flush with water for at least 15 min.get medical attention. |
| 消火手順 | In case of fire, water should be applied by the sprinkler system or by hose from a safe distance, preferably with a fog nozzle. Foam may be necessary instead if the peroxide is diluted in a low density flammable solvent. Portable extinguishers should not be used except for very small fires. Peroxides threatened by fire should be wetted from a safe distance for cooling. /Peroxides, Organic and Inorganic/ |
| 保管条件 | ...SHOULD BE STORED IN COOL, VENTILATED, ISOLATED AREA AWAY FROM ORG OR OTHER EASILY OXIDIZABLE MATERIALS &...ACUTE FIRE HAZARDS. CONTAINERS SHOULD BE KEPT CLOSED & CLEARLY LABELED. /PEROXIDES, ORG/BECAUSE OF THEIR INSTABILITY, MANY PEROXIDES ARE STORED & HANDLED IN AN INERT VEHICLE SUCH AS DIMETHYLPHTHALATE. ... STORAGE TEMP SHOULD NOT EXCEED 30 °C. /PEROXIDES, ORG/ |
| 清掃方法 | Spills should be cleaned up promptly using non-sparking tools and an inert, moist diluent such as vermiculite or sand. Sweepings may be placed in open containers or polyethylene bags and the area washed with water and detergent. Spilled, contaminated, waste or questionable peroxides should be destroyed. /Peroxides, Organic and Inorganic/Most peroxides can be hydrolyzed by adding them slowly with stirring to about ten times their weight of cold 10% sodium hydroxide solution. The reaction may require several hours. /Peroxides, Organic and Inorganic/Dilute and drain into the sewer with abundant water. /Hydrogen peroxide/ |
| 非火災時の漏出対応 | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Excerpt from ERG Guide 146 [Organic Peroxides (Heat, Contamination and Friction Sensitive)]: |
| 処分方法 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
| Isolation and Evacuation | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Excerpt from ERG Guide 146 [Organic Peroxides (Heat, Contamination and Friction Sensitive)]: |
| Personal Protective Equipment (PPE) | Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:Goggles or face shieldrubber glovesprotective clothing. (USCG, 1999)...STRONGLY RECOMMENDED THAT WORKMEN WEAR SAFETY GOGGLES, AN APRON, & RUBBER BOOTS. /ORG PEROXIDES/RECOMMENDED...RESPIRATOR TO AVOID INHALATION OF EXTENSIVE AMT...IN VAPOR FORM... /ORG PEROXIDES/Persons handling peroxides should use safety glasses with side shields, goggles or face shield for eye protection. Emergency eyewash facilities should be provided. Gloves, aprons and other protective clothing as necessary should be used to prevent skin contact. Clothing and equipment that generate static electricity should be avoided. Smoking should be prohibited. /Peroxides, Organic and Inorganic/ |
| 有害作用 | Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect |
| Human Toxicity Excerpts | ...AN ALLERGEN RESPONSIBLE FOR SKIN SENSITIZATION IN MAN.INDUSTRIALLY IT HAS CAUSED OCULAR IRRITATION...PROLONGED INHALATION OF VAPORS RESULTS IN HEADACHE & THROAT IRRITATION... PROLONGED SKIN CONTACT WITH CLOTHING CONTAMINATED WITH PEROXIDES MAY CAUSE IRRITATION & BLISTERING. /ORG PEROXIDES/In the workplace the peroxide has caused eye irritation and skin sensitization. Prolonged inhalation of vapors result in headache and throat irritation. Prolonged skin contact with clothing contaminated with peroxides may cause irritation and blistering.The main toxic effect of most peroxides is irritation of skin, mucous membranes and eyes. Prolonged or intense skin contact or splashes in the eyes may cause severe injury. ... /Peroxides, Organic and Inorganic/ |
| Non-Human Toxicity Excerpts | MIGHT BE EXPECTED TO HAVE CORROSIVE ACTION ON SKIN & MUCOUS MEMBRANE....TESTS ON RABBIT EYES BY APPLICATION OF 40-50% SOLN IN CYCLOHEXANONE OR IN DIMETHYL PHTHALATE...CAUSE MODERATELY SEVERE CORNEAL INJURY WITH SUPERFICIAL OPACITY & ASSOCIATED CONJUNCTIVAL INFLAMMATION.CYCLOHEXANONE PEROXIDE TREATMENT OF MALE RATS INCR INCIDENCE OF EMBRYONIC DEATH & DECR AVG WT OF 1ST GENERATION OFFSPRING, BUT DID NOT AFFECT % OF FEMALES IMPREGNATED OR NUMBER OF EMBRYOS/FEMALE.CYCLOHEXANONE PEROXIDE ADMIN TO RATS ORALLY @ 10% LD50 (0.072 G/KG) DAILY FOR 30 DAYS DECR MOBILITY PERIOD OF SPERMATOZOIDS, PRODUCED VIBRATIONAL MOVEMENT & SOME 2-TAILED SPERMATOZOIDS.For more Non-Human Toxicity Excerpts (Complete) data for CYCLOHEXANONE PEROXIDE (7 total), please visit the HSDB record page. |
| Populations at Special Risk | Individuals with eye, skin, and chronic respiratory diseases /may be/ at an increased risk. /Hydrogen peroxide/ |
| Antidote and Emergency Treatment | PROMPT WASHING OF AFFECTED AREAS IS ESSENTIAL. /PEROXIDES, ORG/Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool .... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Organic peroxides/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic peroxides/Peroxides should be washed promptly from the skin to prevent irritation. In the case of eye contact, the eyes should be flushed immediately with large amounts of water, and medical attention should be obtained. ... Medical attention should also be obtained in case of accidental ingestion. ... /Peroxides, Organic and Inorganic/ |
| TSCA 収載状態 | TSCA listed |
| 輸送番号（UN） | UN 2117/2118/2119/2896 |
| 危険文句（R） | 60-61-3-7-22-34 |
| 危険表示 | E,T |
| 安全措置（S） | 53-3/7-14-26-35-36/37/39-45 |
用途
一般的な説明
White solid dissolved in some unkown organic solvent. Responders should try to identify the solvent being used. Solvent is added to lessen explosion hazard.