データを補完しています。通常は 1 分以内に完了します
基本情報
- CAS
87239-81-4- 標準SMILES
COCC1=C(C(=O)OC(C)OC(=O)OC(C)C)N2C(=O)[C@@H](NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1- InChIKey
LTINZAODLRIQIX-FBXRGJNPSA-N- 分子式
- C21H27N5O9S2
- 平均分子量
- 557.6 g/mol
- 単同位体質量
- 557.12501944
概要
Cefpodoxime proxetil is the 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pharyngitis, and sinusitis. It has a role as an antibacterial drug and a prodrug. It is a cephalosporin, a carboxylic ester and a carboxylic acid. It is functionally related to a cefpodoxime and a 4-{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl}-thiazol-2-yl-ammonium.
名称と識別子
- 優先名称
- Cefpodoxime Proxetil
- IUPAC
- 1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
名称と別名
cefpodoxime proxetil87239-81-4VantinBananOreloxOtreonCS-807CefodoxSimplicefPodomexefU-76252DTXSID1022766
名称をさらに表示
2TB00A1Z7NCHEBI:3505NSC-759161DTXCID802766(RS)-1-((Isopropoxycarbonyl)oxy)ethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylatecephalosporin 807Proxetil, Cefpodoxime807, Cephalosporin
データベース識別子
- CAS
87239-81-4- PubChem CID
- 6526396
- DTXSID
DTXSID1022766- ChEMBL
CHEMBL1201016- ChEBI
CHEBI:3505- UNII
- 2TB00A1Z7N
- EC Number
- 688-311-3、918-886-0
- Nikkaji
- J227.713A
物性
構造計算による物性補完中
- XLogP
- 0.6
- 極性表面積
- 235 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 14
- 回転可能結合数
- 13
- 重原子数
- 37
- 形式電荷
- 0
- 複雑度
- 976
実験および物理化学的性質
DrugsPharmaceuticals -> Antibiotics
LogP1.7
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
安全と法規制
GHS分類
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 10 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin]
危険有害性情報
Hazard Classes and Categories
Skin Sens. 1 (50%)
Skin Sens. 1 (100%)
毒性情報
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Cefpodoxime proxetil
Ambiguous-DILI-concern
3
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
化学と産業
薬理情報
FDA Pharmacological Classification
CEFPODOXIME PROXETIL
Cephalosporin Antibacterial [EPC]; Cephalosporins [CS]
MeSH Pharmacological ClassificationBactericidal agents that contain a beta-lactam ring in their chemical structure. They inhibit bacterial cell wall synthesis by binding to PENICILLIN-BINDING PROTEINS, preventing the synthesis of peptidoglycan in bacterial cell walls.
関連反応
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化合物ノート
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