Ceftazidime Pentahydrate

HCID 6536864
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データを補完しています。通常は 1 分以内に完了します

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基本情報

CAS
78439-06-2
標準SMILES
CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O.O.O.O.O.O
InChIKey
NMVPEQXCMGEDNH-TZVUEUGBSA-N
分子式
C22H32N6O12S2
平均分子量
636.7 g/mol
単同位体質量
636.15196246

概要

Ceftazidime pentahydrate is a hydrate that is the pentahydrate of ceftazidime, a cephalosporin having 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups. It contains a ceftazidime.

名称と識別子

優先名称
Ceftazidime Pentahydrate
IUPAC
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrate

名称と別名

Ceftazidime pentahydrate78439-06-2Ceftazidime hydrateDTXSID0045599CHEBI:3509DTXCID8025599RefChem:574982(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetylamino)-3-(pyridinium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate pentahydrateModacinGlazidimCeftazidime CRSTazicef (TN)
名称をさらに表示
MFCD00153936(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;pentahydrateCeftazidime Pentahydrate(Contain 1 equivalent of Na2CO3 as stabilizer)NCGC00017137-01Ceftazidime (USP)CAS-78439-06-2CEFTAZIDIME [USAN]CEFTAZIDIME [VANDF]

データベース識別子

CAS
78439-06-2
PubChem CID
6536864
DTXSID
DTXSID0045599
ChEMBL
CHEMBL3186392
ChEBI
CHEBI:3509
UNII
9M416Z9QNR
EC Number
616-626-8

物性

構造計算による物性補完中

極性表面積
250 Ų
水素結合供与体数
8
水素結合受容体数
17
回転可能結合数
8
重原子数
42

実験および物理化学的性質

Chemical ClassesOther Uses -> Pharmaceuticals
Human Drugs · 2 件

Breast Feeding; Lactation; Anti-Infective Agents; Antibacterial Agents; Cephalosporins

Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antibacterial Agents; Cephalosporins

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 63 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Hazards SummaryMay cause allergic skin reaction and asthma; [Pfizer] Occupational asthma confirmed in a pharmaceutical worker; [Malo]
Hazard Classes and CategoriesSkin Sens. 1 (100%)

毒性情報

Adverse EffectsAsthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.
Effects During Pregnancy and Lactation · 2 件

◉ Summary of Use during Lactation

◉ Summary of Use during Lactation

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

Agents that are structurally similar to other CEPHALOSPORINS but have a broader spectrum of activity against bacteria than the first and second generation cephalosporins. These agents cover more resistant STREPTOCOCCUS, STAPHYLOCOCCUS, gram-positive anaerobes, and more resistant strains of HAEMOPHILUS, NEISSERIA, PROTEUS, ESCHERICHIA COLI, and KLEBSIELLA (HNPEK).

用途と製造

UsesA cephalosporin antibiotic; [Pfizer]

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