基本情報
- CAS
151-06-4- 標準SMILES
CC(C)(N)Cc1ccc(Cl)cc1.Cl- InChIKey
WEJDYJKJPUPMLH-UHFFFAOYSA-N- 分子式
- C10H15Cl2N
- 平均分子量
- 220.14 g/mol
- 単同位体質量
- 219.0581549
概要
Chlorphentermine Hydrochloride is the hydrochloride salt form of chlorphentermine, a chlorinated analogue of phentermine, a sympathomimetic amine with central nervous system (CNS) stimulating and anorexic activity. Chlorphentermine acts by facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibits their uptake. The increase in synaptic concentrations of these catecholamines causes behavioral changes including an increase in motor activity, mental alertness and excitement, causes euphoria, and suppresses appetite.
名称と識別子
- 優先名称
- Chlorphentermine Hydrochloride
- IUPAC
- 1-(4-chlorophenyl)-2-methylpropan-2-amine;hydrochloride
- 現地名
- 塩酸クロルフェンテルミン
- 英語名
- chlorphentermine hydrochloride
- 分子式
- C10H14ClN.ClH
- 分子量
- 0
名称と別名
Chlorphentermine hydrochloride151-06-4Pre-SateLucofenChlorphentermine HClNSC-76098DTXSID1047815RL11HOJ7DMW 2426p-Chloro-alpha,alpha-dimethylphenethylamine hydrochlorideDTXCID3027792Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride
名称をさらに表示
塩酸クロルフェンテルミン2-(4-クロロベンジル)-2-プロパンアミン・塩酸塩α,α-DiMeImidazo[2,1-b]oxazole,6-(5-fluorophenyl)-p-Chloro-α,α-diMethylphenethylaMine Hydrochloride4-Chloro-α,α-diMethylphenethylaMine Hydrochloride(4-Chlorophenyl)-2-Methylpropan-2-aMine Hydrochloride4-Chloro-a,a-diMethyl-benzeneethanaMine hydrochloride4-Chloro-α,α-diMethyl-1-benzeneethanaMine Hydrochloride
W-2426NSC76098RefChem:54809Hydrochloride, Chlorphentermine205-782-91-(4-chlorophenyl)-2-methylpropan-2-amine hydrochlorideDezopimonLucofene
データベース識別子
物性
構造計算による物性
- 極性表面積
- 26 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 1
- 回転可能結合数
- 2
- 重原子数
- 13
- 形式電荷
- 0
- 複雑度
- 137
実験および物理化学的性質
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
物理化学的性質
- 融点
- 234 ℃ · 234℃
- 溶解性
- 2 O: · H2O: 2 mg/mL, clear
- 外見
- 個体
- 色
- white to beige
- SMILES
- NC(C)(C)CC1=CC=C(C=C1)Cl.Cl
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
危険有害性情報
Regulatory InformationBenzeneethanamine, 4-chloro-.alpha.,.alpha.-dimethyl-, hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 3 (100%)
安全データ
- 毒性
- LD50 in mice (mg/kg): 270 orally; 267 s.c. (Ciborska)
化学と産業
薬理情報
MeSH Pharmacological Classification
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
応用分野
使用chlorphentermine hydrochloride is an anorectic agent. Chlorphentermine is the 4-chloro derivative of the better known appetite suppressant Phentermine (P318830). chlorphentermine hydrochloride is structurally related to amphetamine but is a relatively weak stimulant with little abuse potential.
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