基本情報
- CAS
21730-16-5- 標準SMILES
CNC1Cc2ccccc2N(C)c2ccccc21- InChIKey
YXVZOBVWVRFPTE-UHFFFAOYSA-N- 分子式
- C16H18N2
- 平均分子量
- 238.33 g/mol
- 単同位体質量
- 238.14699858
概要
Metapramine is a dibenzooxazepine.
名称と識別子
- 優先名称
- Metapramine
- IUPAC
- N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine
- 現地名
- 10,11-ジヒドロ-5-メチル-10-(メチルアミノ)-5H-ジベンゾ[b,f]アゼピン
- 英語名
- Metapramine
- 分子式
- C16H18N2
- 分子量
- 238.33
名称と別名
Metapramine21730-16-5MetapraminaMetapraminum303954M7YF10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz(b,f)azepineDTXSID6086501119560-RPRefChem:156796DTXCID7081346715-methyl-10-methylamino-10,11-dihydrodibenzo(b,f)-azepineMetapramine [INN]
名称をさらに表示
10,11-ジヒドロ-N,5-ジメチル-5H-ジベンゾ[b,f]アゼピン-10-アミンメタプラミン10,11-ジヒドロ-5-メチル-10-(メチルアミノ)-5H-ジベンゾ[b,f]アゼピンN,2-ジメチル-2-アザトリシクロ[9.4.0.03,8]ペンタデカ-1(15),3,5,7,11,13-ヘキサエン-9-アミンRP 19560Metapramine USP/EP/BP10,11-Dihydro-5-Methyl-10-5H-Dibenz[b,f]azepine5-Methyl-10-MethylaMino-10,11-dihydrodibenzo[b,f]azepine10,11-Dihydro-N,5-diMethyl-5H-Dibenz[b,f]azepin-10-aMine5H-Dibenz[b,f]azepin-10-amine, 10,11-dihydro-N,5-dimethyl-10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz[b,f]azepine
N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amineMetapraminum [Latin]Metapramina [Spanish]Metapraminum [INN-Latin]Metapramina [INN-Spanish]10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-methyl-10-(methylamino)- (8CI); 10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine; Metapramine; RP 1956019560 RPMETAPRAMINE [MI]
物性
構造計算による物性
- XLogP
- 3
- 極性表面積
- 15.3 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 2
- 回転可能結合数
- 1
- 重原子数
- 18
- 形式電荷
- 0
- 複雑度
- 278
物理化学的性質
- 融点
- 237 · 237-240 °C
- 沸点
- 350.8 · 350.8±42.0 °C(Predicted)
- 比重(密度)
- 1.12 · 1.12±0.1 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解性
- DMSO（微量）、メタノール（微量）
- 外見
- 油
- 酸解離定数(Pka)
- 9.09 · 9.09±0.20(Predicted)
- 色
- 無色～淡黄色～濃厚
- 安定性
- 吸湿性
化学と産業
薬理情報
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
応用分野
説明Metapramine is an antidepressant with a pharmacological profile similar to the tricyclics and an apparent rapid clinical onset of action. Metapramine differs biochemically from the tricyclics in that it markedly enhances norepinephrine turnover with minimal inhibition of reuptake. Like the tricyclics, however, it does down regulate β-receptors.
使用Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.
上流・下流製品情報
上流原料
サプライヤー13 社
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
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