チオリダジン塩酸塩
アルダジン · ノボリダジン · リダジン · 塩酸チオリダジン · スタレリル · メラリル塩酸塩 · マロロール · オルサニル
識別子と物理属性
| CAS No. | 130-61-0 |
|---|---|
| 分子式 | C21H27ClN2S2 |
| 平均分子量 | 407.04 g/mol |
| SMILES | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2.[Cl-].[H+] |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| PubChem CID | 657213 |
| 現地名 | チオリダジン塩酸塩 |
化学・物理的性質
| 融点 | 158-1600C |
|---|---|
| 沸点 | 230°C (rough estimate) |
| 密度 | 1.1227 (rough estimate) |
| 屈折率 | 1.5610 (estimate) |
| 貯蔵条件 | 2-8°C |
| 溶解度 | H2O: 可溶250 mg プラス 5 ml の溶媒、透明、無色から微黄色水 (75 mM)、DMSO (100 mM)、クロロホルム、エタノール、メタノールに可溶。 |
| 外観・状態 | オフホワイトの無地 |
| 色 | White to Almost white |
| Merck | 14,9359 |
| InChI | 1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| SMILES | Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 |
| CAS データベース | 130-61-0(CAS DataBase Reference) |
| NISTの化学物質情報 | Thioridazine hydrochloride(130-61-0) |
| EPAの化学物質情報 | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (130-61-0) |
化学的特性
Pale Yellow Solid
安全性と法規制
| 水環境危害等級（WGK） | 3 |
|---|---|
| RTECS 番号 | SP2275000 |
| 輸送番号（UN） | UN 3077 9/PG 3 |
| 税関コード | 2934302300 |
| 危険文句（R） | 22-36/37/38-50/53 |
| 危険表示 | Xn,N |
| 安全措置（S） | 26-36-60-61 |
| 危険等級 | 9Acute Tox. 4 Oral |
| 貯蔵分類 | 11 - Combustible Solids |
用途
使用
Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.
一般的な説明
Thioridazine hydrochloride,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine monohydrochloride (Mellaril), is amember of the piperidine subgroup of the phenothiazines.The drug has a relatively low tendency to produce EPS. Thedrug has high anticholinergic activity, and this activity in thestriatum, counterbalancing a striatal DA block, may be responsiblefor the low EPS. It also has been suggested thatthere may be increased DA receptor selectivity, which may be responsible. The drug has sedative and hypotensive activityin common with chlorpromazine and less antiemeticactivity. At high doses, pigmentary retinopathy has been observed.Its major metabolites include N-demethylated, ringhydroxylated,and S-oxidized products. Thioridazine isprominently converted to the active metabolite mesoridazine(discussed next), which probably contributes to the antipsychoticactivity of thioridazine.