クロルイミプラミン·塩酸塩

用途三環系抗うつ作用化合物です。 クロミプラミンはイミプラミンのクロール誘 導体です。イミプラミンなどの他の三環系抗 うつ作用物質と比べ、ノルアドレナリン取り 込み阻害作用と比較してセロトニン取り込み 阻害作用を強く示します。

用途三環系抗うつ作用化合物です。 クロミプラミンはイミプラミンのクロール誘 導体です。イミプラミンなどの他の三環系抗 うつ作用物質と比べ、ノルアドレナリン取り 込み阻害作用と比較してセロトニン取り込み 阻害作用を強く示します。

説明Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine . Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively). It also is an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively).

使用Serotonin reuptake inhibitor. Antidepressant; antiobsessional agent

一般的な説明Clomipramine (Anafranil) is up to 50 times as potentas imipramine in some bioassays. This does not implyclinical superiority, but it might be informative about tricyclicand, possibly, other reuptake inhibitors. The chloro replacingthe H-substituent could increase potency by increasingdistribution to the CNS, but it is unlikely that this wouldgive the potency magnitude seen. It might be conjecturedthat an H-bond between the protonated amino group (as invivo) and the unshared electrons of the chloro substituent might stabilize a β-arylamine–like shape and give moreefficient competition for the transporter. The drug is anantidepressant. It is used in obsessive–compulsive disorder,an anxiety disorder that may have an element of depression.

定義ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias.